Lipopolysaccharide and a social stressor influence behaviour, corticosterone and cytokine levels: Divergent actions in cyclooxygenase-2 deficient mice and wild type controls

Hayley, Shawn; Mangano, Emily; Strickland, Michael R.; Anisman, Hymie

doi:10.1016/j.jneuroim.2008.03.015

Cited by 29 publications

(23 citation statements)

References 55 publications

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“…injection of 100 μg LPS in mice [41] and higher levels of corticosterone can be detected 2 weeks after i.p. injection of 10 μg LPS [42]. In our study, the chosen time points for determination of corticosterone levels were 0, 3, 6, 9 h after CH treatment, which were matched with other parameters.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of chloral hydrate against lipopolysaccharide/D-galactosamine-induced acute lethal liver injury and zymosan-induced peritonitis in mice

Yuan

Zheng

Xiao

et al. 2010

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Protective effect of chloral hydrate against lipopolysaccharide/D-galactosamine-induced acute lethal liver injury and zymosan-induced peritonitis in mice

Yuan

Zheng

Xiao

et al. 2010

International Immunopharmacology

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“…As shown previously (Sokolov et al, 1991), long term exposure to stress, irrespective of its causes, leads to changes in the amount and composi tion of microflora on the animal body surface. The adrenal reaction to stress accounts for multilevel changes in parameters of the immune response (Padgett et al, 2003;Kim et al, 2004;Morales et al, 2006;Nazli et al, 2006;Hayley et al, 2008, Sheriff et al, 2009, which produces an effect on the microf lora: first, common skin bacteria increase in numbers, and then changes take place in the species composi tion of microbial associations (Ushakova, 1984;Sokolov and Ushakova, 1986;Sokolov et al, 1990a, b;Sokolov et al, 1991;Ushakova and Shubkina, 1991). These changes in quantitative and qualitative parame ters of the body surface microflora are characteristic specifically of the generalized adaptation response of mammals, including humans (Campis et al, 2002(Campis et al, , 2003Cheng et al, 2006;Kim et al, 2004, Lewis andMcKay, 2009).…”

Section: Introductionmentioning

confidence: 99%

Factors influencing the hunting success of the predator: A model with sighthounds

Shubkina

Северцов

Chepeleva

2012

Biol Bull Russ Acad Sci

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Using microbiological criteria (the number of CFU in nose prints on agar medium), it has been shown that the proportion of individuals with a high CFU count is significantly higher among brown hares caught by sighthounds or exposed to immobilization stress than among shot hares. A hypothesis is proposed that metabolites of the body surface microflora in animals exposed to long term stress account for their spe cific stress odor. Observations on wild hare coursing with the use of GPS tracking (1 s update rate) provide evidence that hunting success is not directly dependent on the absolute and relative coursing speeds, the num ber of sighthounds, and the distance, duration, and number of coursing episodes. An analysis has been per formed of stress odor as a universal criterion allowing the predator to estimate the vulnerability of potential prey. Selective elimination of unhealthy (stressed) individuals by predators is a mechanism of natural selec tion for increased adaptation of populations and species to the effects of a broad spectrum of environmental factors.

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“…Reductions in general activity following exposure to LPS have previously been reported in the literature, with several groups showing significant hypoactivity in the open field (Swiergiel and Dunn, 2007; Yirmiya et al, 1994), home cage (Hayley et al, 2008; Huang et al, 1999), and other behavioral paradigms (e.g., the elevated plus-maze; Swiergiel and Dunn, 2007). Additionally, reduced sexual (Yirmiya, 1996) and social behaviors (Arakawa et al, 2009; Bluthe et al, 1992b; Fishkin and Winslow, 1997) have been consistently observed.…”

Section: Discussionmentioning

confidence: 64%

Acute illness-induced behavioral alterations are similar to those observed during withdrawal from acute alcohol exposure

Richey

Doremus-Fitzwater

Buck

et al. 2012

Pharmacology Biochemistry and Behavior

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Exposure to an immunogen results in a constellation of behavioral changes collectively referred to as “sickness behaviors,” with alterations in cytokine expression previously shown to contribute to this sickness response. Since behaviors observed during ethanol withdrawal are strikingly similar to sickness behaviors, we hypothesized that behavioral manifestations of ethanol withdrawal might be an expression of sickness behaviors induced by ethanol-related changes in peripheral and/or central cytokine expression. Accordingly, behaviors exhibited during a modified social investigation test were first characterized in male rats following an acute injection of lipopolysaccharide (LPS; 100 μg/kg). Subsequently, behavioral changes after either a high (4-g/kg; Experiment 2) or low dose (0.5 g/kg; Experiment 3) of ethanol were also examined in the same social investigation test, as well as in the forced-swim test (FST; Experiment 4). Results from these experiments demonstrated similar reductions in both exploration and social investigatory behavior during acute illness and ethanol withdrawal, while a seemingly paradoxical decrease in immobility was observed in the FST during acute ethanol withdrawal. In follow-up studies, neither indomethacin (Experiment 5) nor interleukin-1 receptor antagonist (Experiment 6) pre-exposure reversed the ethanol withdrawal-induced behavioral changes observed in this social investigation test. Taken together, these studies demonstrate that the behavioral sequelae of acute illness and ethanol withdrawal are similar in nature, while antagonist studies suggest that these behavioral alterations are not reversed by blockade of IL-1 receptors or inhibition of prostaglandin synthesis. Though a direct mechanistic link between cytokines and the expression of acute ethanol withdrawal-related behaviors has yet to be found, future studies examining the involvement of brain cytokines as potential mediators of ethanol effects are greatly needed.

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Lipopolysaccharide and a social stressor influence behaviour, corticosterone and cytokine levels: Divergent actions in cyclooxygenase-2 deficient mice and wild type controls

Cited by 29 publications

References 55 publications

Protective effect of chloral hydrate against lipopolysaccharide/D-galactosamine-induced acute lethal liver injury and zymosan-induced peritonitis in mice

Protective effect of chloral hydrate against lipopolysaccharide/D-galactosamine-induced acute lethal liver injury and zymosan-induced peritonitis in mice

Factors influencing the hunting success of the predator: A model with sighthounds

Acute illness-induced behavioral alterations are similar to those observed during withdrawal from acute alcohol exposure

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