Lipophorins, a major class of lipoproteins of insect haemolymph

Chino, Haruo; Downer, Roger; Wyatt, G.R.; Gilbert, Lawrence I.

doi:10.1016/0020-1790(81)90085-8

Cited by 156 publications

(52 citation statements)

References 15 publications

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“…During oogenesis in insects, oocytes accumulate a great amount of lipids, which are supplied by lipophorin, a major hemolymphatic lipoprotein (Chino et al 1981, Sun et al 2000, Ziegler and Ibrahim 2001. Lipophorin transports different classes of lipids, such as diacylglycerol, phospholipids, cholesterol, hydrocarbons, free fatty acids, between insect various tissues, according to physiological demand (Soulages and Wells 1994, Blacklock and Ryan 1994, Ryan and Van der Horst 2000.…”

Section: Lipophorinmentioning

confidence: 99%

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Oogenesis and egg development in triatomines: a biochemical approach

Atella

Gondim

Machado

et al. 2005

An. Acad. Bras. Ciênc.

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In triatomines, as well as in other insects, accumulation of yolk is a process in which an extra-ovarian tissue, the fat body, produces yolk proteins that are packed in the egg. The main protein, synthesized by the fat body, which is accumulated inside the oocyte, is vitellogenin. This process is also known as vitellogenesis. There are growing evidences in triatomines that besides fat body the ovary also produces yolk proteins. The way these yolk proteins enter the oocyte will be discussed. Yolk is a complex material composed of proteins, lipids, carbohydrates and other minor components which are packed inside the oocyte in an organized manner. Fertilization triggers embryogenesis, a process where an embryo will develop. During embryogenesis the yolk will be used for the construction of a new individual, the first instar nymph. The challenge for the next decade is to understand how and where these egg proteins are used up together with their non-protein components, in pace with the genetic program of the embryo, which enables cell differentiation (early phase of embryogenesis) and embryo differentiation (late phase) inside the egg.

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Section: Lipophorinmentioning

confidence: 99%

“…The major hemolymph lipoprotein of insects is called lipophorin, and its most studied role is the inter organ transport of lipids (Chino et al 1977(Chino et al , 1981, thus lipids can be carried and delivered to the ovaries . Lipophorin is also stored inside the oocytes of moths (Telfer et al 1991).…”

Section: Introductionmentioning

confidence: 99%

Oogenesis and egg development in triatomines: a biochemical approach

Atella

Gondim

Machado

et al. 2005

An. Acad. Bras. Ciênc.

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“…Everyone working in the field of insect lipoproteins had different terms for the apoproteins, and it was important to establish a common set of names. Thus, we used the name lipophorin, originally coined by Chino et al (8), and called the apoproteins apolipophorins, with the designations I, II, and III, from largest to smallest. Kawooya, with pure apolipophorin III (apoLpIII) in hand, moving between Tucson and Chicago, and collaborating with Wells and Kézdy, provided important details about the physical properties of the protein.…”

Section: Wwwannualreviewsorg • Breaking Goodmentioning

confidence: 99%

Breaking Good: A Chemist Wanders into Entomology

Law

2015

Annu. Rev. Entomol.

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In this highly personal account of my career in science, I try to show how many others influenced its course. I was able to abandon work in pure chemistry and microbiology and to take up research in entomology only with the help of others. My faith in the value of collaborative, interdisciplinary work has been the key to success. Our focus on proteins of insect hemolymph has provided valuable insights into insect biochemistry and physiology.

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“…The energy is stored as fat, storage protein, and glycogen. In the silkworm Bombyx mori and other lepidopterans, incorporated fatty acids are converted to and stored as diacylglyceride in lipophorin, amino acids in storage proteins, and sugars in trehalose, mostly in the hemolymph (Wyatt, 1967;Chino et al, 1981;Mullins, 1985;Miller et al, 1990). Thus, hemocoel serves as a storage site for energy molecules.…”

Section: Introductionmentioning

confidence: 99%

Possible involvement of proteinaceous and non-proteinaceous trehalase inhibitors in the regulation of hemolymph trehalose concentration in Bombyx mori

Tatun

Singtripop

Osugi

et al. 2009

Appl. Entomol. Zool.

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The midgut of the silkworm Bombyx mori contains two types of trehalase: soluble and membrane-bound. The trehalose concentration in larval hemolymph remains substantially high through the feeding period of the last (fifth) larval instar, despite appreciable trehalase activity through this period. We found that B. mori larval hemolymph contains two types of trehalase inhibitor, a proteinaceous inhibitor (inhibitor-P) and an inhibitor that is extractable with methanol and ethanol (inhibitor-M). Both inhibit the two types of trehalase, but with different sensitivities. Inhibitor-P inhibited soluble trehalase (ST) more effectively than membrane-bound trehalase (MT), while inhibitor-M inhibited MT slightly more than ST. The inhibitory activity of inhibitor-M was high during the early to middle feeding period, followed by a sudden decrease during the late feeding period. Inhibitor-P activity increased throughout the feeding period, and markedly decreased 2 days after gut purge. Thus, the two inhibitors exhibited stage-specific changes in the hemolymph, indicating coordinated inhibitory activity. Therefore, trehalose concentration regulation in the hemolymph appears to be complex, consisting of at least two inhibitors and two types of trehalase.

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Lipophorins, a major class of lipoproteins of insect haemolymph

Cited by 156 publications

References 15 publications

Oogenesis and egg development in triatomines: a biochemical approach

Oogenesis and egg development in triatomines: a biochemical approach

Breaking Good: A Chemist Wanders into Entomology

Possible involvement of proteinaceous and non-proteinaceous trehalase inhibitors in the regulation of hemolymph trehalose concentration in Bombyx mori

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