Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging

Kim, Ae-Kyeong; Kwon, Dae Woo; Yeom, Eunbyul; Lee, Kwang-Pyo; Kwon, Ki‐Sun; Yu, Kweon; Lee, Kyu-Sun

doi:10.1016/j.bbrc.2021.06.080

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…When comparing the lifespans of the sponge and miR-6-sp lines, it was noted that miR-6 inhibition leads to a significantly (p < 0.05) longer life (Figure 1.4 B). This is consistent with previous reports of LpR2 knockdown in skeletal muscle leading to a significantly shortened lifespan [67].…”

Section: Heart-specific and Ubiquitous Inhibition Of Mir-6 Have Broad...supporting

confidence: 94%

“…As such, it is reasonable to suggest that LpR2 has a stronger effect on the observed changes to the heart upon miR-6 inhibition. It has been previously reported that muscle-specific LpR2 knockdown results in a decrease to the Drosophila lifespan, which was associated with a decline in mitochondrial function [67]. Furthermore, the scaffolding apolipoprotein, apoLpp, which constitutes the main protein component of the LpR2 ligand, lipophorin, has been shown to play dual roles in the fat bodies and cardiomyocytes, through which it regulates systemic lipid metabolism and heart function [82][83][84].…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of Drosophila microRNA-6 increases lipid droplet accumulation in cardiomyocytes but mitigates age-related cardiac arrhythmia and extends lifespan

Komp

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Section: Heart-specific and Ubiquitous Inhibition Of Mir-6 Have Broad...supporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Inhibition of Drosophila microRNA-6 increases lipid droplet accumulation in cardiomyocytes but mitigates age-related cardiac arrhythmia and extends lifespan

Komp

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“…For example, short‐term induction of Drp1 in middle‐aged Drosophila is sufficient to improve organismal health, including exercise capacity (Rana et al., 2018). More upstream mitochondrial dynamics‐related regulators have been identified and are summarized in Table 2 (Aung et al., 2019; Goljanek‐Whysall et al., 2020; Kim et al., 2021; Ma et al., 2020; Mahmoodzadeh et al., 2021; Pillai et al., 2021; Tokuyama et al., 2022; Zhang et al., 2021). How to use these targets to maintain the balance of mitochondrial dynamics during muscle aging and maintain muscle health has attracted the attention of researchers.…”

Section: Mqc Involved In Muscle Agingmentioning

confidence: 99%

Targeting mitochondrial quality control in muscle aging: Natural dietary products as potential interventions

et al. 2023

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Mitochondria are the main sources of energy production for muscle tissues, including skeletal, cardiac, or smooth muscle, to support their activities. Mitochondrial dysfunction and dysregulation of their quality control systems are significant characteristics in aged muscle. Increasing evidence indicates that natural products, especially phytochemicals, can prevent or improve age‐related muscle disorders. Among them, some dietary components specifically regulate mitochondrial quality control (MQC) to play their efficacy. However, the content of related studies is currently not systematically reviewed. In this review, composition, changes, and associated regulators in the MQC network during muscle aging were summarized by comprehensive literature retrieval. Subsequently, the effects and mechanisms of dietary active ingredients on this control network were described. This review showed that mitochondrial dysfunction is a common feature in different types of muscle aging. And four main ways of MQC are involved in maintaining mitochondrial homeostasis and they form a tight and integral system, for muscle‐healthy aging. The benefits of specific endogenous metabolites and exogenous components on aged muscle health are mediated in the above ways. Dietary phytochemicals including phenols, terpenoids, and alkaloids, unfold their influential roles in delaying muscle aging via promoting mitochondrial biogenesis and mitophagy. These findings suggest that MQC is a promising action site against muscle aging and food or herbal‐derived natural products are representative potential interventions. More clinical studies in the future are worthy of future investigation of these natural products.

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Presenilin and Alzheimer’s disease interactions with aging, exercise and high-fat diet: A systematic review

GAO¹,

Wen²,

WANG³

et al. 2023

Biocell

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Presenilin (Psn) protein is associated with organismal aging. Mutations in the Psn gene may lead to Alzheimer's disease (AD), dilated cardiomyopathy (DCM), and many age-dependent degenerative diseases. These diseases seriously affect the quality of life and longevity of the population and place a huge burden on health care and economic systems around the world. Humans have two types of Psn, presenilin-1 (PSEN1) and presenilin-2 (PSEN2). Mutations in the genes encoding PSEN1, PSEN2, and amyloid precursor protein (APP) have been identified as the major genetic causes of AD. Psn is a complex gene strongly influenced by genetic and environmental factors. The effects of exercise, training, and a high-fat diet on the Psn gene expressed in the heart and its related pathways are not fully understood.Fortunately, relevant aspects of the mutational effects on Psn can be studied experimentally in easily handled animal models, including Drosophila, mice, and other animals, all of which share orthologous genes of Psn with humans.Many previous studies have linked aging, exercise training, and a high-fat diet to the Psn gene. This review discusses the interrelationship between aging, exercise training, and a high-fat diet on the Psn gene and its associated disease, AD. The aim is to understand the adverse effects of Psn gene mutations on the body and the diseases caused by AD, find ways to alleviate the adverse effects and provide new directions for the improvement of treatment strategies for diseases caused by Psn gene mutations.

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Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging

Cited by 4 publications

References 44 publications

Inhibition of Drosophila microRNA-6 increases lipid droplet accumulation in cardiomyocytes but mitigates age-related cardiac arrhythmia and extends lifespan

Inhibition of Drosophila microRNA-6 increases lipid droplet accumulation in cardiomyocytes but mitigates age-related cardiac arrhythmia and extends lifespan

Targeting mitochondrial quality control in muscle aging: Natural dietary products as potential interventions

Presenilin and Alzheimer’s disease interactions with aging, exercise and high-fat diet: A systematic review

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