Lipophilicity of oils and fats estimated by TLC

Abstract

A representative series of natural toxins belonging to alkaloids and mycotoxins classes was investigated by TLC on classical chemically bonded plates and also on oils- and fats-impregnated plates. Their lipophilicity indices are employed in the characterization and comparison of oils and fats. The retention results allowed an accurate indirect estimation of oils and fats lipophilicity. The investigated fats and oils near classical chemically bonded phases are classified and compared by means of multivariate exploratory techniques, such as cluster analysis, principal component analysis, or fuzzy-principal component analysis. Additionally, a concrete hierarchy of oils and fats derived from the observed lipophilic character is suggested. Human fat seems to be very similar to animal fats, but also possess RP-18, RP-18W, and RP-8.

Studying of the Lipophilicity and Toxicity of Diphenylacetamide Derivatives

“…Lipophilicity is often defined by the partition coefficient, log P, which represents the concentration ratio of the compound in both phases of the saturated system 1-octanol/water [9,10]. The chromatographic parameters, RM0 and m, obtained by thin layer chromatography on reversed phase (RPTLC) are often applied as alternative measures of the lipophilicity [11][12][13][14][15][16][17][18]. For further examination in the design of a new drug, in addition to lipophilicity and good bioavailability, it is impor-tant to predict its possible toxic effects to the society and the environment.…”