Lipopeptides development in cosmetics and pharmaceutical applications: A comprehensive review

Pilz, Melania; Cavelius, Philipp; Qoura, Farah; Awad, Dania; Brück, Thomas

doi:10.1016/j.biotechadv.2023.108210

Cited by 6 publications

(6 citation statements)

References 394 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These compounds are produced by microorganisms such as yeast, fungi, or bacteria, and classified by chemical composition and molecular weight. Commercialization efforts are growing for various types of glycolipid as well as lipopeptide biosurfactants demonstrating a growing interest in these natural alternatives in an attempt to reflect chemically synthesized surfactants ( Pilz et al, 2023 ). Applications are found in detergency, emulsification, de-emulsification, wetting, foaming, dispersion, solubilization of hydrophobic substances, and surface modification and are summarized in Table 2 .…”

Section: Biosurfactants In the Home And Personal Care Industrymentioning

confidence: 99%

Advances in the production of biosurfactants as green ingredients in home and personal care products

Nasser,

Sharma,

Kaur

2024

Front. Chem.

View full text Add to dashboard Cite

Home and personal care industry is currently witnessing a growing demand for sustainable and eco-friendly alternatives to synthetic surfactants. This increase is fueled by concerns over the delayed degradation and environmental impact of the latter. To this, biosurfactants possess important properties such as biodegradability, low toxicity, and renewable sourcing. These qualities position them as compelling replacements of traditional synthetic surfactants. Their diverse attributes including emulsification, antimicrobial efficacy, surface tension reduction, and foaming capability, make them well-suited choices for home and personal care products. Biosurfactants can be produced through several inexpensive and renewable sources which contributes to their commercialization potential. This article discusses various microbial derived biosurfactants including rhamnolipids, sophorolipids, mannosyl-erythritol lipids, trehalolipids and lipopeptides, unraveling and comparing their distinctive roles and advantages in the home and personal care industry. It also focuses on the recent patent innovations in the production of biosurfactants which have aimed at improving their economic viability and performance attributes. Finally, the article sheds light on the challenges and future trajectories for better integration of these sustainable biosurfactants into mainstream consumer products.

show abstract

Section: Biosurfactants In the Home And Personal Care Industrymentioning

confidence: 99%

Advances in the production of biosurfactants as green ingredients in home and personal care products

Nasser,

Sharma,

Kaur

2024

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…Lipopeptides exhibit immense promise for integration into various cosmetic formulations thanks to their remarkable surface attributes such as detergency, emulsification, solubilization, dispersion, and foaming capabilities. Moreover, they demonstrate noteworthy anti-wrinkle and moisturizing effects on the skin [ 221 , 222 ]. In comparison to synthetic surfactants, lipopeptides offer several advantages, including reduced irritancy or even anti-irritating effects, superior moisturization, and compatibility with the skin [ 9 ].…”

Section: Potential Application Of Biosurfactantmentioning

confidence: 99%

The Physicochemical and Functional Properties of Biosurfactants: A Review

Dini,

Bekhit,

Roohinejad

et al. 2024

Molecules

View full text Add to dashboard Cite

Surfactants, also known as surface-active agents, have emerged as an important class of compounds with a wide range of applications. However, the use of chemical-derived surfactants must be restricted due to their potential adverse impact on the ecosystem and the health of human and other living organisms. In the past few years, there has been a growing inclination towards natural-derived alternatives, particularly microbial surfactants, as substitutes for synthetic or chemical-based counterparts. Microbial biosurfactants are abundantly found in bacterial species, predominantly Bacillus spp. and Pseudomonas spp. The chemical structures of biosurfactants involve the complexation of lipids with carbohydrates (glycolipoproteins and glycolipids), peptides (lipopeptides), and phosphates (phospholipids). Lipopeptides, in particular, have been the subject of extensive research due to their versatile properties, including emulsifying, antimicrobial, anticancer, and anti-inflammatory properties. This review provides an update on research progress in the classification of surfactants. Furthermore, it explores various bacterial biosurfactants and their functionalities, along with their advantages over synthetic surfactants. Finally, the potential applications of these biosurfactants in many industries and insights into future research directions are discussed.

show abstract

“…The A domain activates amino acids, the T domain elongates the peptide chain, and the Cs domain condenses lipid and peptide moieties at the N‐terminus. Lipidation, involving the attachment of a fatty acid moiety, is a crucial step, with various mechanisms, such as direct integration and involvement of hybrid enzymes (Pilz et al., 2023). Termination of peptide elongation is facilitated by the TE domain where the hydrolysis or macrocyclization of the peptide occurs (Kopp & Marahiel, 2007; Strieker et al., 2010).…”

Section: Gene Expression and Biosynthesis Of Lipopeptidesmentioning

confidence: 99%

“…The lipopeptide cyclization occurs during or after the elongation of the peptide chain and is facilitated by the NRPS domains. The cyclic structure can be achieved through various mechanisms, leading to the formation of macrolactones, β‐lactams, or other macrocycles (Pilz et al., 2023; Schwarzer et al., 2003). Cyclization can involve the attachment of the N‐ or C‐terminal amino acid to the lipopeptide backbone moieties, resulting in the formation of diverse cyclic lipopeptide structures (Schimana et al., 2002).…”

Section: Gene Expression and Biosynthesis Of Lipopeptidesmentioning

confidence: 99%

“…Genetic modification strategies are considered as another promising approach to enhance the production of lipopeptides. Various approaches encompassing precursor availability, knockout of lipopeptide degradation pathways, and manipulating promoters are employed to optimize lipopeptide production (Pilz et al., 2023). Increased lipopeptide titers involve precursor‐derived strategies, such as feeding amino acid precursors, such as leucine or lipids, which demonstrated an up to a 20‐fold increase in surfactin production (Wu, Zhi, et al., 2019).…”

Section: Source and Production Of Lipopeptidesmentioning

confidence: 99%

See 1 more Smart Citation

Production, characterization, and potential applications of lipopeptides in food systems: A comprehensive review

Dini,

Oz,

Bekhit

et al. 2024

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Lipopeptides are a class of lipid–peptide‐conjugated compounds with differing structural features. This structural diversity is responsible for their diverse range of biological properties, including antimicrobial, antioxidant, and anti‐inflammatory activities. Lipopeptides have been attracting the attention of food scientists due to their potential as food additives and preservatives. This review provides a comprehensive overview of lipopeptides, their production, structural characteristics, and functional properties. First, the classes, chemical features, structure–activity relationships, and sources of lipopeptides are summarized. Then, the gene expression and biosynthesis of lipopeptides in microbial cell factories and strategies to optimize lipopeptide production are discussed. In addition, the main methods of purification and characterization of lipopeptides have been described. Finally, some biological activities of the lipopeptides, especially those relevant to food systems along with their mechanism of action, are critically examined.

show abstract

Lipopeptides development in cosmetics and pharmaceutical applications: A comprehensive review

Cited by 6 publications

References 394 publications

Advances in the production of biosurfactants as green ingredients in home and personal care products

Advances in the production of biosurfactants as green ingredients in home and personal care products

The Physicochemical and Functional Properties of Biosurfactants: A Review

Production, characterization, and potential applications of lipopeptides in food systems: A comprehensive review

Contact Info

Product

Resources

About