Lipomatous secretory meningioma: case report and review of the literature

Liebig, Thomas; Hoffmann, Thomas Sören; Hosten, Norbert; Sander, B.; Landeghem, Frank K.H. van; Stoltenburg-Didinger, G.; Lanksch, W.

doi:10.1007/s002340050658

Cited by 18 publications

(17 citation statements)

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“…The same features have been previously demonstrated in other reports [13,22,29,35,38]. Pseudopsammo ma bodies are most frequently associated with the meningothelial pattern of the tumour, however they might occur also in other histological subtypes of benign meningiomas, including lipomatous or vacu olated component [18,20,21,39]. The secretory men ingiomas of the present study, comprised tumours with the basic growth pattern of the meningothelial type (4 cases), angiomatous type (2 cases), transi tional type (1 case) and fibroblastic type (1 case).…”

Section: Discussionsupporting

confidence: 86%

Original article Secretory meningiomas: immunohistochemical pattern of lectin and ultrastructure of pseudopsammoma bodies

Taraszewska

Matyja²

2014

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Section: Discussionsupporting

confidence: 86%

Original article Secretory meningiomas: immunohistochemical pattern of lectin and ultrastructure of pseudopsammoma bodies

Taraszewska

Matyja²

2014

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“…Meningioma with the most remarkable T1W hyperintensity is observed in lipomatous meningioma and xanthomatous meningioma, and the high signal intensity is due to the lipid content of the meningioma cells [2,3,10,12,21]. However, these meningiomas demonstrating T1W hyperintensity are visualized as low-density lesions by CT.…”

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confidence: 84%

A Meningioma with Hyperintensity on T1-Weighted Images in a Dog

Hasegawa¹,

Kobayashi²,

Fujita³

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. A male six-year-old Pomeranian showed recurrent seizures and progressive left hemiparesis. MRI revealed a mass in the right paramedian frontal-temporal region with hyperintensity on T1-weighted (T1W) and mixed-intensity on T2-weighted (T2W) images. After gadolinium enhancement, the mass was enhanced homogenously and demonstrated the dural tail sign. Surgical resection of mass was performed and its histological diagnosis was meningioma. The meningioma of this case had a high cellular density with some lipid contents and intra-and extra-tumor hemorrhage, however, calcification was not found. These cellular characteristics may contribute to a higher signal intensity on T1W imaging. KEY WORDS: Meningioma, MRI, T1-weighted hyperintensity.J. Vet. Med. Sci. 70(6): 615-617, 2008 A male 6-year-old Pomeranian was presented to the Animal Medical Center of Nippon Veterinary and Animal Science University with progressive left hemiparesis and recurrent seizures that lasted for 2 weeks. According to the owner, each seizure began with a systemic tremor as if the animal was scared, and developed to a generalized tonicclonic seizure. Neurological examination revealed right circling and reduced postural reactions of the left front and hind limbs, which suggested the presence of a right prosencephalic lesion. General physical examinations, as well as blood, urine, and radiographic examinations revealed no remarkable abnormality. Therefore, magnetic resonance (MR) imaging was performed for further scrutiny.MR imaging revealed an irregular mass in the right paramedian frontal-parietal region with hyperintensity on T1-weighted (T1W) images (Fig. 1A), and hyper-to hypointensity (mixed-intensity) on T2 weighted (T2W) images (Fig. 1B) and fluid-attenuated inversion recovery (FLAIR) images. The margin of the mass revealed hypointensity on both T1W and T2W images. The mass was relatively welldelineated, but seemed to infiltrate the sagittal sinus. The adjacent brain tissue was compressed by the mass and a cingulate herniation with a midline shift was observed (ie, mass effect). Brain edema was also observed, predominantly in the white matter around the mass. Contrast enhanced T1W images after an intravenous injection of gadodiamide (Gd-T1W) revealed a near homogeneous contrast enhancement of the mass, accompanied by the dural tail sign along the meninges from the falx cerebri to the frontal-parietal region (Fig. 1C). Computed tomography (CT) was also performed and demonstrated the mass as a slightly high-density region (contrast enhanced CT was not performed).At the owner's request, a craniotomy was performed and resection of the mass was carried out. The mass was dark reddish, markedly soft, and fragile with a bleeding tendency. Most of the dura mater was separated easily, but the pia mater and the cortex of the cerebrum were difficult to separate due to a partial infiltration of the mass into the cortex. Because of the infiltration into the sagittal sinus and for conservation of the sinus, resection of the midline area was i...

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“…[1] Lipomatous meningioma, also known as lipomeningioma or lipoblastic meningioma, is a rare entity and only 36 cases have been described in the English literature. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The largest series included 18 cases [3] and ours is probably the second largest series of lipomatous meningioma. Lipomatous meningiomas represented 0.3% of all meningiomas operated at the Mayo Clinic over 15 years period.…”

Section: Discussionmentioning

confidence: 99%

“…[3,4] The studies on lipomatous meningioma are limited, and only 36 cases have been described in the literature. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] In this study, we describe the clinical course, neuro-radiological features and morphology of 5 patients with lipomatous meningioma.…”

Section: Introductionmentioning

confidence: 99%

Lipomatous meningioma: A study of five cases with brief review of literature

et al. 2011

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Lipomatous meningiomas are an uncommon subtype of meningiomas. In the present report, the clinical characteristics, neuroimaing and pathological features of 5 patients (4 males, 1 female; age range, 17-45 years; mean age, 35.2 years) with lipomatous meningioma were analyzed. The neuro-pathological reevaluation of lipomatous meningioma involved assessment of histological features proposed by the current WHO classification. The presence or absence of high whorls, fascicles, solid growth, glial invasion, necrosis and nuclear pleomorphism was assessed. The most common presenting symptom was seizures. Location of tumor was frontal (3 cases), parietal (1 case) and fronto-temporal (1 case). All cases showed radiological features of conventional meningioma. Complete excision of tumor along with involved dura was performed in all the patients. Three tumors were meningothelial and 2 were transitional. Tumoral lipid content was variable from 10% to 30%. In addition, there were microcystic features (2 cases) and psammoma bodies (1 case). No recurrence was noted in any of our cases till the last follow-up. Lipomatous meningioma represents a rare distinctive type of meningioma, with a good prognosis with complete removal.

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Lipomatous secretory meningioma: case report and review of the literature

Cited by 18 publications

References 10 publications

Original article Secretory meningiomas: immunohistochemical pattern of lectin and ultrastructure of pseudopsammoma bodies

Original article Secretory meningiomas: immunohistochemical pattern of lectin and ultrastructure of pseudopsammoma bodies

A Meningioma with Hyperintensity on T1-Weighted Images in a Dog

Lipomatous meningioma: A study of five cases with brief review of literature

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