Lipoma of the Uterine Corpus: Exceptional Eventuality Combined with an Ovarian Thecoma

Abstract

Uterine lipomas are very uncommon with symptoms that are similar to leiomyomas. Their diagnosis is always histological although some radiological methods may suggest their existence prior to surgery. They are sometimes associated with endometrial pathology, but there are no previous reported cases related to ovarian thecoma. Their prognosis is excellent. Clinical, radiological, morphologic, and immunohistochemical findings are shown which correspond to uterine lipoma associated with endometrial polyps and ovarian thecoma.

A pure uterine lipoma: a rare, benign entity

“…While lipomas by themselves are quite common, a uterine lipoma is very rare. This entity was originally described in 18161 and since then, only a small number of cases have been described in the literature worldwide. The reported incidence is approximately 0.03–0.2% 2 3…”

Uterine Lipoma: A Very Rare Cause of Postmenopausal Bleeding

“…As fat tissue is not native to the uterus, various theories of histogenesis have been proposed. These include misplaced embryonic fat cells, metaplasia of the muscle or connective tissue cells into the fat cells, lipocytic differentiation of specific primitive connective tissue cells, proliferation of perivascular fat cells accompanying the blood vessels into the uterus, inclusion of the fat cells into the uterine wall during surgery or fatty infiltration or degeneration of the connective tissue [4]. The fact that most patients are postmenopausal women leads to the suggestion that fat metabolism changes in this stage may play a role in lipomatous metaplasia [6].…”

“…The diagnosis of pure lipoma should only be made when smooth muscle, if any, is confined to the periphery of the tumour [3]. The clinical manifestations do not usually differ greatly to those caused by leiomyomas except that they usually affect postmenopausal women [4]. Most lipomas are located in the body of the uterine corpus.…”

A Case Report and Review of the Literature on Uterine Fatty Tumours (UFT): A Field of Heterogeneous Data

“…Uterine fatty tumours (UFT) or lipoleiomyomas (LLM) are a kind of leiomyomas with prevalent fatty component occurring mostly in peri-menopausal and postmenopausal obese women. Many clinical and pathological aspects of these uncommon uterine nodules have been already reported [2][3][4][5][6]. Nonetheless literature largely varies with a prevalence of radiological case-reports for clinical data and histo-pathological review analysis on pathogenesis investigation.…”

“…This has corresponded to 75 independent studies here separately reported in 3 different tables: Table 1 for all clinical studies (n=46), Table 2 for pathological review data analysis (n=16) and Table 3 for malignant uterine tumours with fatty component and endometrial cancers coincidental with benign fatty tumours (n=13). Mean patient age, tumour size and incidence of UFT (which varied accordingly to the criteria used being low -0.03%-in hysterectomy and higher -0.8-2.1%-in uterine leiomyomas studies) along with symptoms and methodology used for preoperative tumour study and detection are summarized in table 4. No association whatsoever between aging and tumour size has been noted (Table 1).…”