Lipoid Pneumonia Associated A Chronic Aspiration Of Evening Primrose Oil

Rabahi, Marcelo Fouad; Ferreira, Andréia A.; Reciputti, Bruno Pereira; Matos, Thalita O.; Madeira, João Gabriel P.; Pinto, Sebastião Alves; Galvao, Paulo Menzel

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4504

Cited by 4 publications

(9 citation statements)

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“…Exogenous LP is even recognized as an occupational disease . Therefore, the patient interview is the first key element for suspecting the diagnosis . Unfortunately, as in our case, the patient history of lipid exposure is often asked only after radiological or cytological exams.…”

Section: Discussionmentioning

confidence: 99%

“…This disease tends to be bilateral, with a predilection for the lower lobes because of declivity. Although LP mimics numerous lung conditions, CT scan has proved to be the best imaging modality , often raising the suspicion of exogenous LP . The most commonly described feature is an alveolar consolidation with low density ranging from −30 UH to −150 Hounsfield units, which corresponds to fat tissue, as well as ground‐glass opacities, interlobular septal thickening, and “crazy paving” .…”

Section: Discussionmentioning

confidence: 99%

“…In performing arts, a fire‐breather creates a fireball by breathing a small quantity of fuel over an open flame, as opposed to a fire‐eater, who pretends to swallow fire. Various factors may increase the risk of exogenous LP, such as extremes of age, structural, or anatomical abnormalities of the pharynx and esophagus, psychiatric disorder, dementia, and swallowing dysfunction , but are not systematically present .…”

Section: Discussionmentioning

confidence: 99%

“…It is noteworthy that oils reach the bronchial tree without stimulating the cough reflex, by impairing the mucociliary transport system . Once in the alveoli, the accumulated lipids create a chronic foreign body reaction involving foamy macrophages . Broncho‐alveolar lavage (BAL) can be helpful not only for the treatment, but also to confirm the diagnosis , revealing a greasy fluid with fat globules on its surface.…”

Section: Discussionmentioning

confidence: 99%

“…Testing of lung function mostly reveals restrictive or mixed (obstructive and restrictive) defects. The transfer factor for carbon monoxide is also frequently abnormal . Chest radiographs usually show abnormalities that can vary from a homogenous consolidation to the presence of nodules.…”

Section: Discussionmentioning

confidence: 99%

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Exogenous Lipoid Pneumonia as a Contributory Factor in a Drug‐related Death

Moreau

Rérolle

Deveaux³

et al. 2014

Journal of Forensic Sciences

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Postmortem investigation often reveals various conditions, which may or may not have played a part in the death of the individual. The case of a 32-year-old woman is reported, with a long history of drug addiction. She was found dead in her bed. The autopsy revealed diffuse pulmonary edema with congestion of the lungs, brain, liver, and spleen. Microscopic examination of the lungs showed multiple intra-alveolar and interstitial foamy macrophages and extracellular fat droplets surrounded by polynuclear giant cells. Death was attributed to acute polydrug intoxication. As microscopic examination had revealed severe pulmonary lesions, lipoid pneumonia was considered as a contributing factor to death. Lipoid pneumonia is an uncommon entity with the characteristic radiograph features and histologic findings of alveoli filled with vacuolated, lipid-laden histiocytes. It can be either exogenous or endogenous in cause, based on the source of the lipid. Exogenous lipoid pneumonia usually results from aspiration or inhalation of fat-like material, such as mineral oil or petroleum-based lubricants and decongestants, resulting in pulmonary inflammatory reactions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Exogenous Lipoid Pneumonia as a Contributory Factor in a Drug‐related Death

Moreau

Rérolle

Deveaux³

et al. 2014

Journal of Forensic Sciences

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The effect of therapeutic bronchoalveolar lavage in combination with glucocorticoids on children with acute exogenous lipoid pneumonia

Yang

et al. 2023

Clinical Respiratory J

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Background Exogenous lipoid pneumonia (ELP) is a rare disease caused by the inhalation of oily materials in the alveoli with the pathological characterization by the presence of laden‐lipid macrophages in the respiratory specimens. At present, the treatment norm for ELP has not well defined, and so the aim of this study is to evaluate the effect of bronchoalveolar lavage in combination with glucocorticoids on children with ELP. Methods and Materials We retrospectively reviewed 17 children with a confirmed history of exogenous oily materials aspiration, admitted to the First Affiliated Hospital of Guangzhou Medical University from June 2012 to December 2021. Clinical features, blood investigations, tomographic evaluations, therapeutic bronchoalveolar lavage and glucocorticoids use were carried out at the beginning of therapy and throughout a follow‐up period. Results The included children are the median age of 2 years. Fever, dypnea and tachypnea were the most common symptoms. The most common radiological features were airspace consolidations (15, 93.75%). Chest CT scans showed areas of consolidation with air bronchogram (15, 93.75%), poorly defined centrilobular nodules (13, 81.25%), areas of ground‐glass attenuation (11, 68.75%) and ‘crazy‐paving’ pattern (6, 37.5%) in the both lower, right middle lung lobes. Neutrophil percentage of peripheral blood and bronchoalveolar lavage fluid exhibited a significantly higher than the normal range. After treatment with multiple bronchoalveolar lavages and local administration of budesonide during the hospital stay, taken by oral prednisolone (1 ~ 2 mg/kg) after discharge, all of children became asymptomatic and presented normal radiological imagings in the follow‐up period. Conclusion The most frequently findings in the CT scan of ELP were consolidations and ground‐glass attenuation in the both lower and right middle lung lobes. Multiple bronchoalveolar lavages in combination with oral prednisolone for children who had a confirmed history of exogenous oily substances ingestion were an efficient and safe for the clearance of oily materials from the lung and the prevention of fibrosis. This strategy contributed to reducing the damage of ELP in children patients.

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Lipoid pneumonia: case reports

Чикина¹,

Авдеев²,

Trushenko³

et al. 2012

Pulʹmonologiâ (Mosk.)

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Рис. 1. Компьютерная томография легких: в средних и нижних отделах легких участки затемнений по типу "матового стекла" с уплот нением меж и внутридольковых перегородок, участок консолидации в средней доле правого легкого Заметки из практики

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Lipoid Pneumonia Associated A Chronic Aspiration Of Evening Primrose Oil

Cited by 4 publications

References 0 publications

Exogenous Lipoid Pneumonia as a Contributory Factor in a Drug‐related Death

Exogenous Lipoid Pneumonia as a Contributory Factor in a Drug‐related Death

The effect of therapeutic bronchoalveolar lavage in combination with glucocorticoids on children with acute exogenous lipoid pneumonia

Lipoid pneumonia: case reports

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