Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet

Кравченко, Л В; Aksenov, I V; Nikitin, N.S.; Guseva, G V; Avrenyeva, Ludmila I.; Трусов, Н В; Балакина, А С; Tutelyan, V A

doi:10.3390/nu13061999

Cited by 6 publications

(4 citation statements)

References 59 publications

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“…Several studies evidence a positive systemic ALA role in promoting antioxidant activity. For instance, a dose of 600 mg/day ALA increased plasma SOD activity in diabetic patients [44] as well as rats fed a hypercaloric choline-deficient diet showed a significant increase in plasma SOD after receiving ALA [45]. Moreover, ALA supplementation restored the transcription of gene encoding SOD which was decreased by HFD in mice plasma [46].…”

Section: Discussionmentioning

confidence: 98%

The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance

2022

Cell Physiol Biochem

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Background/Aims: Correlation between type 2 diabetes and other abnormalities such as obesity with redox balance disturbance was analyzed in many reports. Nonetheless, antioxidants impact on parameters accompanying these conditions is still unknown. Currently the role of redox imbalance in the adipose tissue has gained a lot of attention. Methods: We investigated the impact of α-lipoic acid (ALA) on plasma glucose and insulin concentrations, oxidative stress and inflammation parameters in the subcutaneous (SAT) and visceral (VAT) adipose tissue of high fat diet-fed (HFD) rats. Male Wistar rats were randomly divided into three groups (n = 6) — control diet (CTRL), HFD and HFD with α-lipoic acid (HFD+ALA). Results: HFD increased body weight, plasma insulin and glucose as well as leads to oxidative stress parameters in the adipose tissue. ALA supplementation reduced body weight and oxidative stress parameters more effectively in the visceral than subcutaneous adipose tissue of insulin resistant rats. Conclusion: Insulin resistance led to increased enzymatic and non-enzymatic antioxidant systems, protein and lipid glycoxidation, nitrosative stress, and selected inflammatory parameters more in VAT than in SAT of insulin resistant rats. Moreover, ALA inhibited HFD consequences mainly in VAT mostly through glutathione (GSH) biosynthesis.

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Section: Discussionmentioning

confidence: 98%

The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance

2022

Cell Physiol Biochem

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“…As has been repeatedly shown in clinical observations, deficiency of this vitamin is an important etiological factor in the development of non-alcoholic fatty liver disease [41] and metabolic syndrome [42]; in particular, the latter is reflected in the growth of LDL cholesterol levels in agreement with our observations (see Figure 5c). Deficiency of vitamin B 12 [43] and lipoic acid [44,45] can also disturb lipid metabolism and lead to excess fat accumulation in the liver; this is considered the initial study of steatohepatitis. The accumulation of fat in the liver, most noticeable at the highest dose of BNC in group 4, could have a negative impact on hepatic metabolic function in terms of the transformation of nitrogenous compounds, as reflected by an increase in creatinine levels and a decrease in uric acid in the blood serum; the latter could also result in a decrease in blood antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment—Part 1: The Systemic Effects

Shipelin,

Skiba,

Budaeva

et al. 2024

Nanomaterials

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Bacterial nanocellulose (BNC) is being considered as a potential replacement for microcrystalline cellulose as a food additive and a source of dietary fiber due to its unique properties. However, studies on the risks of consuming BNC in food are limited, and it is not yet approved for use in food in the US, EU, and Russia. Aim: This study aims to perform a toxicological and hygienic assessment of the safety of BNC in a subacute 8-week administration in rats. Methods: BNC was administered to male Wistar rats in doses of 0, 1.0, 10.0, and 100 mg/kg body weight for 8 weeks. Various parameters such as anxiety levels, cognitive function, organ masses, blood serum and liver biochemistry, oxidative stress markers, vitamin levels, antioxidant gene expression, and liver and kidney histology were evaluated. Results: Low and medium doses of BNC increased anxiety levels and liver glutathione, while high doses led to elevated LDL cholesterol, creatinine, and uric acid levels. Liver tissue showed signs of degeneration at high doses. BNC did not significantly affect vitamin levels. Conclusion: The adverse effects of BNC are either not dose-dependent or fall within normal physiological ranges. Any effects on rats are likely due to micronutrient deficiencies or impacts on intestinal microbiota.

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“…The antilipidemic effect observed in this study and inhibition of α-amylase reported previously [19] explain the significant improvement in OGTT by geraniin and GEE. TG overload in the pancreas has been demonstrated to disrupt β-cell function [33] and induce oxidative stress (OS) [34]. Hence, reduction in TG appears to have also improved glucose tolerance.…”

Section: Discussionmentioning

confidence: 99%

The Prebiotic Potential of Geraniin and Geraniin-Enriched Extract against High-Fat-Diet-Induced Metabolic Syndrome in Sprague Dawley Rats

et al. 2022

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Geraniin, an ellagitannin, has ameliorative properties against high-fat diet (HFD)-induced metabolic syndrome. Since geraniin has poor bioavailability, we hypothesised the interaction of this compound with gut microbiota as the main mechanism for improving metabolic aberrations. Male Sprague Dawley rats were divided into normal diet (ND)- and HFD-fed animals and treated with geraniin and an enriched extract of geraniin (GEE). We observed that 5 mg geraniin and 115 mg GEE supplementation significantly attenuated glucose intolerance, lipopolysaccharide-binding protein, total cholesterol, triacylglyceride, and low-density lipoprotein; improved insulin sensitivity; and significantly increased adiponectin and hepatic PPARα expression. Although geraniin and GEE did not significantly alter the gut microbial composition, we found an increment in the relative abundance of a few butyrate producers such as Alloprevotella, Blautia, Lachnospiraceae NK4A136 group, and Clostridium sensu stricto 1. Geraniin and its enriched extract’s ability to ameliorate metabolic syndrome parameters while positively affecting the growth of butyrate-producing bacteria suggests its potential prebiotic role.

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Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet

Cited by 6 publications

References 59 publications

The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance

The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance

Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment—Part 1: The Systemic Effects

The Prebiotic Potential of Geraniin and Geraniin-Enriched Extract against High-Fat-Diet-Induced Metabolic Syndrome in Sprague Dawley Rats

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