Lipoic acid attachment to proteins: stimulating new developments
John E. Cronan
Abstract:SUMMARY
Lipoic acid-modified proteins are essential for central metabolism and pathogenesis. In recent years, the
Escherichia coli
and
Bacillus subtilis
lipoyl assembly pathways have been modified and extended to archaea and diverse eukaryotes including humans. These extensions include a new pathway to insert the key sulfur atoms of lipoate, several new pathways of lipoate salvage, and a novel use of lipoic acid in sulfur-oxidizing bacteria… Show more
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