Lipoic acid as a novel treatment for Alzheimer's disease and related dementias

Holmquist, Lina; Stuchbury, Grant; Berbaum, Katrin; Muscat, Sonja; Young, Simon; Häger, Klaus; Engel, Jürgen; Münch, Gerald

doi:10.1016/j.pharmthera.2006.07.001

Cited by 260 publications

(143 citation statements)

References 82 publications

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“…LA (dexlipotam) has been clinically approved and used for diabetic neuropathy [111,112]. It has been used in Germany for treatment of symptomatic diabetic neuropathy since several years ago [113,114]. According to a meta-analysis performed on 4 RCTs (ALADIN I, ALADIN III, SYDNEY, NATHAN II) including 1,258 patients of diabetic polyneuropathy, LA administration for 3 weeks significantly improved symptoms in the feet [115].…”

Section: -Lipoic Acidmentioning

confidence: 99%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

120

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Abstract:Reactive oxygen species (ROS) are widely believed to cause or aggravate several human pathologies such as neurodegenerative diseases, cancer, stroke and many other ailments. Antioxidants are assumed to counteract the harmful effects of ROS and therefore prevent or treat oxidative stress-related diseases. In this report, recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed. Few antioxidants including edaravone (for ischemic stroke in Japan), Nacetylcysteine (for acetaminophen toxicity), alfa-lipoic acid (for diabetic neuropathy) and some flavonoids (polyphenolic compounds present in dietary plants), such as micronized purified flavonoid fraction (diosmin and hesperidin) and oxerutins (for chronic venous insufficiency) as well as baicalein and catechins (for osteoarthritis) have found accepted clinical use. However, despite much enthusiasm in the 1980s and 1990s, many well-known agents such as antioxidant vitamins and also more recently developed compounds such as nitrones have not successfully passed the scrutiny of clinical trials for prevention and treatment of various diseases. This has given rise to a pessimistic view of antioxidant therapy, however, the evidence from human epidemiological studies about the beneficial effects of dietary antioxidants and preclinical in vitro and animal data are compelling. We have probably wasted too much time on agents like antioxidant vitamins instead of focusing on more disease specific, target-directed, highly bioavailable antioxidants. We here discuss possible reasons for the lack of success in some clinical trials and seek to provide some suggestions to be considered if antioxidant therapy is to succeed as an effective therapeutic strategy.

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Section: -Lipoic Acidmentioning

confidence: 99%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

120

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“…Induced pluripotent stem cell (IPSC) technology, whereby a patient's somatic cells can be reprogrammed to a pluripotent state by the forced expression of a defined set of transcription factors, may offer a way forward to the development of novel personalized neuroprotective therapies that prevent AD (Huber et al 2006;Holmquist et al 2007;. In addition, a growing focus is on biomarkers which enable detection of the disease in its early stages and will allow for preventative treatment (Song et al 2009).…”

Section: Alzheimer's Disease and The Urgent Need For Early Diagnosis mentioning

confidence: 99%

Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer’s disease

et al. 2012

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The use of induced pluripotent stem cells (iPSCs), whereby a patient's somatic cells can be reprogrammed to a pluripotent state by the forced expression of a defined set of transcription factors, has the potential to enable in vitro disease modelling and be used for drug discovery programs. Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that leads to a decline in memory and cognition. Fibroblasts were taken from AD patients (or non‐AD controls) and cultured under specific conditions to generate iPSCs which were then provided with growth factors to allow differentiation into neurons. While AD‐iPSCs were morphologically indistinguishable from control‐iPSCs, differentiated cells showed differing responses to both cellular stresses and neuroprotective drugs. Since these cells are derived from individual patients, the use of iPSCs has provided novel insights into disease pathogenesis, providing information on an individual's variations in the disease process and their cellular response to drugs.

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“…Available treatments amount to several drugs that provide temporary relief or slow progression (Sparks et al 2005;Kehoe and Wilcock 2007;Relkin et al 2009). Risk of AD may be reduced, however, by antioxidants (Grundman and Denaney 2002;Holmquist et al 2007;Cole and Frautschy 2010), healthy diets (Gu et al 2010), environmental enrichment (Jankowski et al 2005;Herring et al 2008), and exercise (Adlard et al 2005). Preservation of cognitive function into older ages is associated with increased longevity (Barzilai et al 2006).…”

Section: Introductionmentioning

confidence: 99%

A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice

Aksenov

Long

Liu

et al. 2011

AGE

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We developed a complex dietary supplement designed to offset five key mechanisms of aging and tested its effectiveness in ameliorating age-related cognitive decline using a visually cued Morris water maze test. All younger mice (<1 year old) learned the task well. However, older untreated mice (>1 year) were unable to learn the maze even after 5 days, indicative of strong cognitive decline at older ages. In contrast, no cognitive decline was evident in older supplemented mice, even when ∼2 years old. Supplemented older mice were nearly 50% better at locating the platform than age-matched controls. Brain weights of supplemented mice were significantly greater than controls, even at younger ages. Reversal of cognitive decline in activity of complexes III and IV by supplementation was significantly associated with cognitive improvement, implicating energy supply as one possible mechanism. These results represent proof of principle that complex dietary supplements can provide powerful benefits for cognitive function and brain aging.

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Lipoic acid as a novel treatment for Alzheimer's disease and related dementias

Cited by 260 publications

References 82 publications

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer’s disease

A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice

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