Lipogenesis in arterial wall and vascular smooth muscle cells of Psammomys obesus: Its regulation and abnormalities in diabetes

Hamlat, Nadjiba; Negazzi, Samia; Forcheron, Fabien; Bricca, G.; Beylot, M.; Aouichat-Bouguerra, S.

doi:10.1016/j.diabet.2010.01.003

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…36 However, our data in combination with the detection of PXR mRNA in SMC from obese Zucker rat and P. obesus gerbil thoracic aorta and in wild-type mouse mesenteric arteries indicate that arterial PXR expression is common across species and that the mRNA is translated into a functional protein. 11,12,18 …”

Section: Discussionmentioning

confidence: 99%

Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress

Swales

Moore

Truss

et al. 2011

Cardiovascular Research

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AimsCirculating endogenous, dietary, and foreign chemicals can contribute to vascular dysfunction. The mechanism by which the vasculature protects itself from these chemicals is unknown. This study investigates whether the pregnane X receptor (PXR), the major transcriptional regulator of hepatic drug metabolism and transport that responds to such xenobiotics, mediates vascular protection by co-ordinating a defence gene programme in the vasculature.Methods and resultsPXR was detected in primary human and rat aortic endothelial and smooth muscle cells (SMC) and blood vessels including the human and rat aorta. Metabolic PXR target genes cytochrome P450 3A, 2B, 2C, and glutathione S-transferase mRNA and activity were induced by PXR ligands in rodent and human vascular cells and absent in the aortas from PXR-null mice stimulated in vivo or in rat aortic SMC expressing dominant-negative PXR. Activation of aortic PXR by classical agonists had several protective effects: increased xenobiotic metabolism demonstrated by bioactivation of the pro-drug clopidogrel, which reduced adenosine diphosphate-induced platelet aggregation; increased expression of multidrug resistance protein 1, mediating chemical efflux from the vasculature; and protection from reactive oxygen species-mediated cell death.ConclusionPXR co-ordinately up-regulates drug metabolism, transport, and antioxidant genes to protect the vasculature from endogenous and exogenous insults, thus representing a novel gatekeeper for vascular defence.

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Section: Discussionmentioning

confidence: 99%

Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress

Swales

Moore

Truss

et al. 2011

Cardiovascular Research

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Section: Introductionmentioning

confidence: 99%

“…Psammomys obesus usually lives on a low energy diet (plants mainly rich in water and minerals) in a natural desert habitat, however, when kept in laboratory conditions fed with a rich diet, the animals show metabolic disorders related to high carbohydrates intake [11,12]. It is an atherosensitive animal which would thus constitute an ideal model for the study of cardiovascular diseases [11,12]. We previously showed Hhcy to induce a myocardial remodeling including extracellular matrix in Psammomys obesus [13], but we did not address the effects of Hhcy on the other components of the cardiovascular system.…”

Section: Introductionmentioning

confidence: 99%

A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Zerrouk

Chaouad

Ghoul

et al. 2022

Folia Histochem Cytobiol.

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. www.journals.viamedica.pl/folia_histochemica_cytobiologica ©Polish Society for Histochemistry and Cytochemistry Folia Histochem Cytobiol.

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Eicosapentaenoic acid modulates fatty acid metabolism and inflammation in Psammomys obesus

et al. 2015

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Lipogenesis in arterial wall and vascular smooth muscle cells of Psammomys obesus: Its regulation and abnormalities in diabetes

Cited by 5 publications

References 35 publications

Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress

Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress

A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Eicosapentaenoic acid modulates fatty acid metabolism and inflammation in Psammomys obesus

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