Lipogenesis and innate immunity in hepatocellular carcinoma cells reprogrammed by an isoenzyme switch of hexokinases

Perrin-Cocon, Laure; Vidalain, Pierre‐Olivier; Jacquemin, Clémence; Aublin-Gex, Anne; Olmstead, Keedrian; Panthu, Baptiste; Gjp, Rautureau; André, Patrice; Nyczka, Piotr; Hütt, Marc‐Thorsten; Amoêdo, Nívea Dias; Rossignol, Rafaëlle; Filipp, Fabian V.; Lotteau,; Diaz, Olivier

doi:10.1101/2020.03.13.973321

Cited by 2 publications

(2 citation statements)

References 75 publications

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“…The connectivity of such a subgraph compared to randomly drawn gene sets is a convenient and frequently employed measure for SC/FC correlations in this context [7,[134][135][136], as it addresses the statistical question, how clustered such a gene set (representing functional connectivity) is within a given (metabolic) network (representing structural connectivity).…”

Section: Application To Systems Biologymentioning

confidence: 99%

A stylised view on structural and functional connectivity in dynamical processes in networks

Voutsa¹,

Battaglia²,

Bracken³

et al. 2021

Preprint

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The relationship of network structure and dynamics is one of most extensively investigated problems in the theory of complex systems of the last years. Understanding this relationship is of relevance to a range of disciplines -from Neuroscience to Geomorphology. A major strategy of investigating this relationship is the quantitative comparison of a representation of network architecture (structural connectivity) with a (network) representation of the dynamics (functional connectivity). Analysing such SC/FC relationships has over the past years contributed substantially to our understanding of the functional role of network properties, such as modularity, hierarchical organization, hubs and cycles.Here, we show that one can distinguish two classes of functional connectivity -one based on simultaneous activity (co-activity) of nodes the other based on sequential activity of nodes. We delineate these two classes in different categories of dynamical processesexcitations, regular and chaotic oscillators -and provide examples for SC/FC correlations of both classes in each of these models. We expand the theoretical view of the SC/FC relationships, with conceptual instances of the SC and the two classes of FC for various application scenarios in Geomorphology, Freshwater Ecology, Systems Biology, Neuroscience and Social-Ecological Systems.Seeing the organization of a dynamical processes in a network either as governed by coactivity or by sequential activity allows us to bring some order in the myriad of observations relating structure and function of complex networks.

show abstract

Section: Application To Systems Biologymentioning

confidence: 99%

A stylised view on structural and functional connectivity in dynamical processes in networks

Voutsa¹,

Battaglia²,

Bracken³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The connectivity of such a subgraph compared to randomly drawn gene sets is a convenient and frequently employed measure for SC/FC correlations in this context [7,[138][139][140], as it addresses the statistical question of how clustered such a gene set (representing functional connectivity) is within a given (metabolic) network (representing structural connectivity).…”

Section: Application To Systems Biologymentioning

confidence: 99%

Two classes of functional connectivity in dynamical processes in networks

Voutsa

Battaglia

Bracken

et al. 2021

J. R. Soc. Interface.

Self Cite

View full text Add to dashboard Cite

The relationship between network structure and dynamics is one of the most extensively investigated problems in the theory of complex systems of recent years. Understanding this relationship is of relevance to a range of disciplines—from neuroscience to geomorphology. A major strategy of investigating this relationship is the quantitative comparison of a representation of network architecture (structural connectivity, SC) with a (network) representation of the dynamics (functional connectivity, FC). Here, we show that one can distinguish two classes of functional connectivity—one based on simultaneous activity (co-activity) of nodes, the other based on sequential activity of nodes. We delineate these two classes in different categories of dynamical processes—excitations, regular and chaotic oscillators—and provide examples for SC/FC correlations of both classes in each of these models. We expand the theoretical view of the SC/FC relationships, with conceptual instances of the SC and the two classes of FC for various application scenarios in geomorphology, ecology, systems biology, neuroscience and socio-ecological systems. Seeing the organisation of dynamical processes in a network either as governed by co-activity or by sequential activity allows us to bring some order in the myriad of observations relating structure and function of complex networks.

show abstract

Lipogenesis and innate immunity in hepatocellular carcinoma cells reprogrammed by an isoenzyme switch of hexokinases

Cited by 2 publications

References 75 publications

A stylised view on structural and functional connectivity in dynamical processes in networks

A stylised view on structural and functional connectivity in dynamical processes in networks

Two classes of functional connectivity in dynamical processes in networks

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