Lipofuscin Pigment Accumulation and Distribution in Five Rat Organs as a Function of Age

Reichel, William

doi:10.1093/geronj/23.2.145

Cited by 130 publications

(25 citation statements)

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“…Biochemical and morphological changes as a result of the aging process have been recognized in the zona reticularis. Mi croscopically, one can see a massive deposi tion of lipofuscin granules in the cytoplasm of reticularis cells in the aged human adrenal cortex [9]. These accumulations may be the result of accelerated lipid peroxidation in the zona reticularis.…”

Section: Introductionmentioning

confidence: 99%

Adrenocortical Responsiveness to Graded ACTH Infusions in Normal Young and Elderly Human Subjects

Ohashi¹,

Kato²,

Nawata³

et al. 1986

Gerontology

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The responses of plasma cortisol, aldosterone, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) to graded ACTH infusions (from 50 mU/h to 1,000 mU/h) in elderly subjects were compared with those in young subjects. There were no significant differences between young and elderly subjects in terms of the levels of plasma cortisol during ACTH infusion. The increment in median serum cortisol increase observed in elderly subjects was also equal to that found in young subjects. Plasma aldosterone concentration showed a gradual increase in response to ACTH infusion in both young and elderly individuals. There was no significant difference between the response of young and aged subjects. Significant increases in serum DHEA in response to ACTH infusion were observed in both young and aged individuals, however, the median increase of serum DHEA (ΔDHEA) in the elderly subjects was markedly lower than that in the young ones. Serum DHEA-S concentrations prior to ACTH infusion were significantly lower in the elderly subjects. With graded infusions of ACTH, plasma DHEA-S concentrations in young subjects tended to increase gradually, whereas there was no significant increase in plasma DHEA-S concentrations in the elderly. These results are indicative that the responses of adrenal androgens in elderly subjects to small, graded doses of ACTH infusion are preferentially impaired; however, the responses of cortisol and aldosterone are well maintained.

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Section: Introductionmentioning

confidence: 99%

Adrenocortical Responsiveness to Graded ACTH Infusions in Normal Young and Elderly Human Subjects

Ohashi¹,

Kato²,

Nawata³

et al. 1986

Gerontology

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“…The occurrence of lipofuscin granules or 'age pigments' in cells and tissues has long been attributed to the accumulation of oxidation products of unsaturated lipids (Casselman, 1951;Strehler, Mark, Mildvan & Gee, 1959;Reichel, 1968;Porta & Hartroft, 1969). These oxidation products have been identified as organic peroxides ; they are produced in a complex series of chemical reactions, ultimately resulting in the destruction of the original lipids.…”

Section: Introductionmentioning

confidence: 99%

Damage to ram spermatozoa by peroxidation of endogenous phospholipids

Jones¹,

Mann²

1977

Reproduction

178

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“…This leads to a decrease in the number of cells and to matrix degeneration (Rahlf 1972;Reichel, 1968;Thur tier, 1969;¿binden, 1953). In is not yet known how the arrange ment of collagenous fibers is changed through the loss of chondrons.…”

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Morphological and Histochemical Studies in Human Rib Cartilage Chondrons of Different Age Groups

Wobst

Hommel

Sames³

1980

Gerontology

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4- to 6-μm thick cryostat sections from rib cartilage of human corpses aged 1 day to 92 years were stained with basic dyes, digested with testes hyaluronidase and examined in polarized light. The areas of 50 chondrons in the cartilage periphery and of 50 chondrons in the cartilage center were measured. The anisotropic zones of the chondrons show a decreased size in the cartilage center as compared to those of the periphery. The basophilic zones of the chondrons (territories) were measured only in the cartilage center. The size of their areas is similar to that of the anisotropic areas. The zones of the chondrons with high chondroitin sulfate content as revealed by hyaluronidase (inner terrritorial zones) are smaller in the cartilage center than in the periphery and decrease with advancing age.

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Lipofuscin Pigment Accumulation and Distribution in Five Rat Organs as a Function of Age

Cited by 130 publications

References 0 publications

Adrenocortical Responsiveness to Graded ACTH Infusions in Normal Young and Elderly Human Subjects

Adrenocortical Responsiveness to Graded ACTH Infusions in Normal Young and Elderly Human Subjects

Damage to ram spermatozoa by peroxidation of endogenous phospholipids

Morphological and Histochemical Studies in Human Rib Cartilage Chondrons of Different Age Groups

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