Lipodystrophia centrifugalis abdominalis infantilis

Giam, Yoke Chin; Rajan, V S; Hock, Ong Beng

doi:10.1111/j.1365-2133.1982.tb04541.x

Cited by 22 publications

(17 citation statements)

References 4 publications

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“…Mild perivascular dermal infiltrate has been reported at the leading edge of LCAI 16,17 . The brisk, deep dermal and lobular lymphocytic infiltrate seen in our case exceeds that presented in other reports.…”

Section: Discussioncontrasting

confidence: 57%

Lipodystrophia centrifugalis abdominalis infantilis in a Caucasian girl: report of a case with perieccrine inflammation

2008

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Lipodystrophia centrifugalis abdominalis infantilis (LCAI) is a rare, self-limiting disease typically affecting Asian children around the age of three. In classic cases, patients present with a hypopigmented patch with central atrophy and an erythematous border in the groin area. We present a case of LCAI affecting a female Caucasian toddler that shows striking perieccrine inflammation, a finding not previously reported in this entity. LCAI has been rarely reported in Caucasian children; as a result, there is sparse literature on the histopathological findings in this subset. This case illustrates how significant deep dermal and perieccrine inflammation can be seen in this condition, thus broadening the histopathological spectrum of this disorder.

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Section: Discussioncontrasting

confidence: 57%

Lipodystrophia centrifugalis abdominalis infantilis in a Caucasian girl: report of a case with perieccrine inflammation

2008

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“…In 1982 Giatn et al (2) and Lee et al (3) described the first cases outside of Japan in a Chinese boy and eight Koreans, respectively. Fewer than 100 cases of LCAI have been reported lo date.…”

mentioning

confidence: 98%

“…Lipodystrophia centrifugalis abdominalis infanlilis (LCAI) is a rare disorder first de.scribed by Imamura et al (1) in 1971. In 1982 Giatn et al (2) and Lee et al (3) described the first cases outside of Japan in a Chinese boy and eight Koreans, respectively. Fewer than 100 cases of LCAI have been reported lo date.…”

mentioning

confidence: 99%

Lipodystrophia Centrifugalis Abdominalis Infantilis: A Case Report

Llistosella

Puig

Pérez

1997

Pediatric Dermatology

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We describe a typical case of lipodystrophia centrifugalis abdominalis infantilis. This rare disorder is almost exclusively seen in Japanese children. The patient, a 3-year-old girl of Chinese ancestry, had a depressed area of skin in the right groin which gradually spread across the abdomen. The lesion had a distinctive, slightly erythematous, raised border and regional lymphadenopathy was present.

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“…The mechanism of LCAI also remains unknown, though several hypotheses have been presented that the degeneration of fatty tissue is the primary change, and the inflammatory change observed in the periphery is a reactive change [3, 6]. In the degenerating subcutaneous fatty tissue, positive staining for HLA-DR, bcl-2, Fas and p53 in mononuclear cells were observed.…”

Section: Discussionmentioning

confidence: 99%

“…The differential diagnosis includes atrophoderma of Pasini-Pierini, morphea, lipogranulomatosis subcutanea, subcutaneous fat necrosis of the newborn and lupus erythematosus profundus [1, 3]. All of these diseases were excluded by clinical and histological findings.…”

Section: Discussionmentioning

confidence: 99%

Lipodystrophia centrifugalis abdominalis infantilis – Immunohistochemical Demonstration of an Apoptotic Process in the Degenerating Fatty Tissue

et al. 2000

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We report a case of lipodystrophia centrifugalis abdominalis infantilis (LCAI) showing apoptosis during the lipoatrophic process by immunohistochemical staining. A 3-year-old boy was seen with a 3-month history of a centrifugally spreading depressed eruption without pain and pruritus on his abdomen. He had fever, diarrhea and vomiting for a week at the beginning of his eruption. Physical examination revealed a palm-sized well-demarcated atrophic plaque on his lower abdomen and left inguinal fold. His plaque showed fine erythema peripherally. A skin biopsy specimen showed remarkably decreased subcutaneous fatty tissue. Inflammatory cell infiltration including lymphocytes and histiocytes was noted in the degenerating fatty tissue. In the degenerating subcutaneous fatty tissue, positive staining for HLA-DR, Fas, bcl-2, p53 and transferase-mediated uridine nick end labeling in mononuclear cells were observed. He was diagnosed as having LCAI. The present case showed the possible involvement of apoptosis in the fatty tissue degeneration in LCAI.

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Lipodystrophia centrifugalis abdominalis infantilis

Cited by 22 publications

References 4 publications

Lipodystrophia centrifugalis abdominalis infantilis in a Caucasian girl: report of a case with perieccrine inflammation

Lipodystrophia centrifugalis abdominalis infantilis in a Caucasian girl: report of a case with perieccrine inflammation

Lipodystrophia Centrifugalis Abdominalis Infantilis: A Case Report

Lipodystrophia centrifugalis abdominalis infantilis – Immunohistochemical Demonstration of an Apoptotic Process in the Degenerating Fatty Tissue

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