LipoCardium: Endothelium-directed cyclopentenone prostaglandin-based liposome formulation that completely reverses atherosclerotic lesions

Site-Specific Inhibition of Glomerulonephritis Progression by Targeted Delivery of Dexamethasone to Glomerular Endothelium

“…The use of endothelial target epitopes other than E-selectin, however, can be taken into account. Immunoliposomes directed toward VCAM-1 were internalized by activated endothelial cells in vitro (Voinea et al, 2005) and, in vivo, demonstrated beneficial effects in an atherosclerosis mouse model (Homem de Bittencourt et al, 2007). The use of VCAM-1-selective immunoliposomes in glomerulonephritis to interfere with microvascular endothelial cells distinct from the glomerular capillaries is an attractive strategy, especially because VCAM-1 is highly expressed throughout disease progression (Allen et al, 1999).…”

Molecular Interactions and Implications of Aldose Reductase Inhibition by PGA1 and Clinically Used Prostaglandins

“…cyPGs bind to and modulate transcription factors (Cernuda-Morollón et al, 2001;Kim and Surh, 2006;Pérez-Sala, 2011), activate the antioxidant response (Levonen et al, 2004;Martínez et al, 2012), inactivate detoxifying enzymes like glutathione transferases (Sánchez-Gómez et al, 2010), and induce antiinflammatory and antiproliferative effects , for which they have been proposed as therapeutic tools (Fukushima et al, 2001;Homem de Bittencourt et al, 2007).…”

Cyclopentenone Prostaglandins with Dienone Structure Promote Cross-Linking of the Chemoresistance-Inducing Enzyme Glutathione Transferase P1-1

“…cyPGs display varied biological effects, including antiproliferative and anti-inflammatory actions, for which a potential pharmacological use of these compounds has been put forward (Ianaro et al, 2003;Homem de Bittencourt et al, 2007). An important mechanism for cyPG action is the formation of covalent adducts with cellular proteins, resulting in altered protein function (Cernuda-Morollón et al, 2001;Pérez-Sala et al, 2003;Sá nchez-Gómez et al, 2004).…”