Lipocalin 2 may be a key factor regulating the chemosensitivity of pancreatic cancer to gemcitabine

Zhang, He; Wu, Pengpeng; Guo, Chenbo; Zhang, Caiqin; Zhao, Yong; Tan, Dengxu; An, Jing; Shi, Changhong

doi:10.1016/j.bbrep.2022.101291

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Lipocalins are a protein family that serve as protease inhibitors during the cell cycle [ 148 , 149 , 150 ]. The role of lipocalins in cancer is controversial [ 149 ]; however, they bind to a wide variety of lipophilic ligands that regulate lipocalin activity [ 151 ]; these lipophilic ligands are present in SKM and display local anti-tumorigenic activity [ 152 ].…”

Section: Local Mechanisms Alleviating Cancer In Skeletal Musclementioning

confidence: 99%

Mechanisms Underlying the Rarity of Skeletal Muscle Cancers

Kump

2024

IJMS

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Skeletal muscle (SKM), despite comprising ~40% of body mass, rarely manifests cancer. This review explores the mechanisms that help to explain this rarity, including unique SKM architecture and function, which prohibits the development of new cancer as well as negates potential metastasis to SKM. SKM also presents a unique immune environment that may magnify the anti-tumorigenic effect. Moreover, the SKM microenvironment manifests characteristics such as decreased extracellular matrix stiffness and altered lactic acid, pH, and oxygen levels that may interfere with tumor development. SKM also secretes anti-tumorigenic myokines and other molecules. Collectively, these mechanisms help account for the rarity of SKM cancer.

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Section: Local Mechanisms Alleviating Cancer In Skeletal Musclementioning

confidence: 99%

Mechanisms Underlying the Rarity of Skeletal Muscle Cancers

Kump

2024

IJMS

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show abstract

“…Lipocalins are a protein family that serve as protease inhibitors during the cell cycle [124][125][126]. The role of lipocalins in cancer is controversial [125]; however, they bind to a wide variety of lipophilic ligands that regulate lipocalin activity [127]; these lipophilic ligands are present in SKM and display local anti-tumorigenic activity [128].…”

Section: Lipophilic Ligands Of the Lipocalin Protein Familymentioning

confidence: 99%

Mechanisms Underlying the Rarity of Skeletal Muscle Cancers

Kump

2024

Preprint

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Skeletal muscle (SKM), despite comprising ~40% of body mass, is rare. This review explores the mechanisms that help to explain this rarity, including unique SKM architecture and function, which prohibits development of new cancer as well as negates potential metastasis to SKM. SKM also presents a unique immune environment that may magnify the anti-tumorigenic effect. Moreover, the SKM microenvironment manifests characteristics such as decreased extracellular matrix stiffness and altered lactic acid, pH, and oxygen levels that may interfere with tumor development. SKM also secretes anti-tumorigenic myokines and other molecules. Collectively, these mechanisms help account for the rarity of SKM cancer.

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Lipocalin-2 promotes breast cancer brain metastasis by enhancing tumor invasion and modulating brain microenvironment

Zhao,

Tang,

Lei

et al. 2024

Front. Oncol.

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Breast cancer is the leading cancer diagnosed in women globally, with brain metastasis emerging as a major cause of death, particularly in human epidermal growth factor receptor 2 positive and triple-negative breast cancer subtypes. Comprehensive understanding of the molecular foundations of central nervous system metastases is imperative for the evolution of efficacious treatment strategies. Lipocalin-2 (LCN2), a secreted iron transport protein with multiple functions, has been linked to the progression of breast cancer brain metastasis (BCBM). In primary tumors, LCN2 promotes the proliferation and angiogenesis of breast cancer cells, triggers the epithelial-mesenchymal transition, interacts with matrix metalloproteinase-9, thereby facilitating the reorganization of the extracellular matrix and enhancing cancer cell invasion and migration. In brain microenvironment, LCN2 undermines the blood-brain barrier and facilitates tumor seeding in the brain by modulating the behavior of key cellular components. In summary, this review meticulously examines the fuel role of LCN2 in BCBM cascade, and investigates the potential mechanisms involved. It highlights the potential of LCN2 as both a therapeutic target and biomarker, indicating that interventions targeting LCN2 may offer improved outcomes for patients afflicted with BCBM.

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Lipocalin 2 may be a key factor regulating the chemosensitivity of pancreatic cancer to gemcitabine

Cited by 3 publications

References 21 publications

Mechanisms Underlying the Rarity of Skeletal Muscle Cancers

Mechanisms Underlying the Rarity of Skeletal Muscle Cancers

Mechanisms Underlying the Rarity of Skeletal Muscle Cancers

Lipocalin-2 promotes breast cancer brain metastasis by enhancing tumor invasion and modulating brain microenvironment

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