Lipocalin-2: a role in hepatic gluconeogenesis via AMP-activated protein kinase (AMPK)

Sun, WX; Lou, Kai; Chen, LJ; Liu, Shudong; Pang, S-G

doi:10.1007/s40618-020-01494-0

Cited by 9 publications

(10 citation statements)

References 64 publications

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“…LCN2 has been shown an intimate association with the metabolism of glucose. Capehorn et al confirmed that improved insulin sensitivity and suppressed gluconeogenesis were present in LCN2 knockout (LCN2KO) mice (116). Currò et al also reported that LCN2 was positively correlated to the homeostatic model assessment (HOMA) index in normal subjects, which suggests a regulatory role of LCN2 in IR (117).…”

Section: Lcn2 In Glucose Metabolismmentioning

confidence: 95%

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The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease

Gu²,

Wang

et al. 2022

Front. Endocrinol.

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Diabetic kidney disease (DKD) causes the greatest proportion of end-stage renal disease (ESRD)–related mortality and has become a high concern in patients with diabetes mellitus (DM). Bone is considered an endocrine organ, playing an emerging role in regulating glucose and energy metabolism. Accumulating research has proven that bone-derived hormones are involved in glucose metabolism and the pathogenesis of DM complications, especially DKD. Furthermore, these hormones are considered to be promising predictors and prospective treatment targets for DM and DKD. In this review, we focused on bone-derived hormones, including fibroblast growth factor 23, osteocalcin, sclerostin, and lipocalin 2, and summarized their role in regulating glucose metabolism and DKD.

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Section: Lcn2 In Glucose Metabolismmentioning

confidence: 95%

“…Capehorn et al. confirmed that improved insulin sensitivity and suppressed gluconeogenesis were present in LCN2 knockout (LCN2KO) mice ( 116 ). Currò et al.…”

Section: Bone-derived Hormones and Dkdmentioning

confidence: 96%

The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease

Gu²,

Wang

et al. 2022

Front. Endocrinol.

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“…GSK-3β can regulate the activity of related enzymes in the glycolysis pathway by phosphorylating liver glycogen synthase, and the decrease of GSK-3β relative expression can improve the activity of liver glycogen synthase, increase liver glycogen synthesis, and reduce liver glycogen output. Glucokinase (GK) is the first rate-limiting enzyme in the glycolysis pathway and can catalyze the glucose-6-phosphatase catalytic (G6PC), which is also the premise of liver glycogen synthesis [36]. Moreover, when the body is in a state of hyperglycemia, GK can increase the uptake of glucose by the liver, and also regulate the synthesis and secretion of insulin by β cells.…”

Section: Effects Of Sdf On Pi3k/akt Insulin Signaling Pathwaymentioning

confidence: 99%

Regulatory Effects of Functional Soluble Dietary Fiber from Saccharina japonica Byproduct on the Liver of Obese Mice with Type 2 Diabetes Mellitus

Zhang

Wang

et al. 2022

Marine Drugs

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Though the relationship between dietary fiber and physical health has been investigated widely, the use of dietary fiber from marine plants has been investigated relatively rarely. The Saccharina japonica byproducts after the production of algin contain a large amount of insoluble polysaccharide, which will cause a waste of resources if ignored. Soluble dietary fiber (SDF)prepared from waste byproducts of Saccharina japonica by alkaline hydrolysis method for the first time had a wrinkled microscopic surface and low crystallinity, which not only significantly reduced liver index, serum levels of aspartate aminotransferase (AST) and alanine amiotransferase (ALT), and liver fat accumulation damage to the livers of obese diabetic mice, but also activated the PI3K/AKT signaling pathway to increase liver glycogen synthesis and glycolysis. By LC-MS/MS employing a Nexera UPLC tandem QE high-resolution mass spectrometer, the 6 potential biomarker metabolites were screened, namely glycerophosphocholine (GPC), phosphocholine (PCho), pantothenic acid, glutathione (GSH), oxidized glutathione (GSSG), and betaine; several pathways of these metabolites were associated with lipid metabolism, glycogen metabolism, and amino acid metabolism in the liver were observed. This study further provided a detailed insight into the mechanisms of SDF from Saccharina japonica byproducts in regulating the livers of obese mice with type 2 diabetes and laid a reliable foundation for the further development and utilization of Saccharina japonica.

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Section: Introductionmentioning

confidence: 99%

“…6 As reported in recent studies, modulation of AMPK mediated hepatic gluconeogenesis involves a crucial role in the amelioration of insulin resistance and diabetes associated disorders. 7,8 With the scientific investigation of medicinal plants using modern tools and techniques followed by the stringent regulatory policy by WHO, the study of herbal medicine has gained a renewed interest and new momentum. Most countries have now focused on their local natural resources for the development of botanical drugs or phytopharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Iridoid glycoside isolated from Wendlandia glabrata and the role of its enriched fraction in regulating AMPK/PEPCK/G6Pase signaling pathway of hepatic gluconeogenesis

et al. 2022

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Lipocalin-2: a role in hepatic gluconeogenesis via AMP-activated protein kinase (AMPK)

Cited by 9 publications

References 64 publications

The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease

The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease

Regulatory Effects of Functional Soluble Dietary Fiber from Saccharina japonica Byproduct on the Liver of Obese Mice with Type 2 Diabetes Mellitus

Iridoid glycoside isolated from Wendlandia glabrata and the role of its enriched fraction in regulating AMPK/PEPCK/G6Pase signaling pathway of hepatic gluconeogenesis

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