Lipocaic and Fatty Infiltration of the Liver in Pancreatic Diabetes

Dragstedt, Lester R.

doi:10.1001/archinte.1939.00190050123009

Cited by 19 publications

(2 citation statements)

References 28 publications

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“…It can be prevented in depancreatized or duct-ligated dogs by feeding raw pancreas or choline or by feeding water-extracted meat powder in place of raw meat. In addition, Dragstedt (15) has reported a pancreatic hormone (lipocaic) capable of preventing fatty infiltration of the liver but the hormonal nature of the extract used has not as yet been confirmed by other investigators. Whether or not the pancreas is involved in the production of the fatty liver in the alcoholic patient is purely a matter of speculation.…”

Section: Discussionmentioning

confidence: 98%

The Liver Lipids in Normal Human Livers and in Cases of Cirrhosis and Fatty Infiltration of the Liver

Ralli¹,

Rubin²,

Rinzler³

1941

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 98%

The Liver Lipids in Normal Human Livers and in Cases of Cirrhosis and Fatty Infiltration of the Liver

Ralli¹,

Rubin²,

Rinzler³

1941

J. Clin. Invest.

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“…The inclusion of lipocaic here, as an internal secretion of the pancreas, depends upon the work of Dragstedt and co-workers (35,36,37). Their contentions, supported by a great deal of careful evidence, are based upon their findings: (a) that ligation of the ex ternal pancreatic ducts does not result in the characteristic fall in serum lipoids and the rise in liver fat which occurs in depancrea tized dogs not receiving raw pancreas, lecithin, or choline in the diet; (b) that administration of large quantities of the external secretion of the pancreas, collected from pancreatic fistulae, does not alleviate the above changes in depancreatized anilllals; and (c) that their simple alcoholic extract of pancreas, named lipocaic, is very potent in relieving the fatty changes, and does not contain sufficient choline to account for the results.…”

Section: Soskinmentioning

confidence: 99%

Metabolic Functions of the Endocrine Glands

Soskin¹

1941

Annu. Rev. Physiol.

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This attempt at a brief review of the contributions of the past year to our knowledge of the metabolic functions of the endocrine glands must of necessity be selective rather than all-inclusive. This is not only because of the number of papers which have appeared, but also because many of the findings cannot yet be related to the pre-existing knowledge. For these reasons it has seemed desirable to limit the present discussion to the most pertinent literature concerning the influence of the pancreas, the adrenal cortex, the thyroid and the anterior hypophysis on the metabolism of carbo hydrates, fats, and proteins respectively.Since it is possible to make only the briefest mention of the related work which appeared before the period under considera tion, the reader is referred to certain review articles published during this time. Van Dyke's second volume on the pituitary gland (144) covers the international literature on the subject from 1935 to 1938. Collip (28) has discussed the significance of the various active fractions of anterior pituitary extracts. The influence of the pituitary gland on carbohydrate metabolism has been re viewed by Young (154) , and of the adrenal cortex by Long and associates (83). Raab (110) has considered the relation of the hor mones to fat metabolism.It is understood that the interpretation of new observations will often depend upon one's previous conception of the funda mentals of the subject. The writer has recently summarized some of his views on carbohydrate metabolism (126, 127). THE PANCREAS A more complete understanding of the influence of other hor mones on carbohydrate metabolism still awaits final agreement as 1 Th e help of Dr. R. Levine in the collection of the material for t " his review is gratefully acknowledged.543 Annu. Rev. Physiol. 1941.3:543-572. Downloaded from www.annualreviews.org Access provided by New York University -Bobst Library on 02/08/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

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Effect of the Administration of Lipocaic and Cholesterol in Rabbits

Vermeulen¹

1942

Arch Surg

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Lipocaic and Fatty Infiltration of the Liver in Pancreatic Diabetes

Cited by 19 publications

References 28 publications

The Liver Lipids in Normal Human Livers and in Cases of Cirrhosis and Fatty Infiltration of the Liver

The Liver Lipids in Normal Human Livers and in Cases of Cirrhosis and Fatty Infiltration of the Liver

Metabolic Functions of the Endocrine Glands

Effect of the Administration of Lipocaic and Cholesterol in Rabbits

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