Lipoblastoma: MRI appearances of a rare paediatric soft tissue tumour

Reiseter, Tor; Nordshus, T; Borthne, Arne; Roald, Borghild; Næss, Paal Aksel; Schistad, Ole

doi:10.1007/s002470050641

Cited by 66 publications

(27 citation statements)

References 3 publications

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“…Lipoblastoma must be suspected in a child < 3 years of age with a predominantly fatty, nonhomogeneous, soft tissue mass on MRI. 29 In the literature, cytologic findings of six FNA cases of lipoblastoma [13][14][15][16][17] and one intraoperative smear are reported. 31 In these reports, the cytologic specimens consist of viscous, mucoid fluid with small, white tissue fragments.…”

Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Leon

Deschler

et al. 2002

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Leon

Deschler

et al. 2002

Acta Cytologica

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“…In the present report, the patient age was relatively old and it was difficult to make a differential diagnosis between myxoid liposarcoma and lipoblastoma. Reiseter et al (1999) reported that MRI is an essential tool for diagnosis and preoperative evaluation of lipoblastoma. MRI can show anatomical detail, which is essential for successful radical tumor excision.…”

Section: Discussionmentioning

confidence: 99%

“…Lipoblastoma is a rare benign soft-tissue childhood tumor occurring most commonly in children less than 3 years of age (Chung and Enzinger 1973;Mentzel et al 1993), and magnetic resonance image (MRI) is a useful tool for its diagnosis and preoperative evaluation (Reiseter et al 1999). MRIs of this type of tumor are typically characterized by high-intensity signals on both T1 weighted (T1-W) and T2 weighted (T2-W) images (Letourneau et al 1993).…”

mentioning

confidence: 99%

Lipoblastoma Mimicking Myxoid Liposarcoma: A Clinical Report and Literature Review

Nagano

Ohno

Nishimoto

et al. 2011

Tohoku J. Exp. Med.

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Lipoblastoma is an uncommon benign lipomatous tumor, occurring typically in children less than 3 years of age. The magnetic resonance image (MRI) is a useful tool for diagnosis of lipoblastoma; its imaging typically shows high-intensity signals on both T1-weighted (T1-W) and T2 weighted (T2-W) images. Here, we present a 12-year-old female patient with a painless mass on the anterior right shoulder. MRI showed the mass with low-intensity signals on T1-W and high-intensity signals on T2-W images. Because of the atypical age and MRI findings, it was difficult to make a conclusive diagnosis of the tumor as lipoblastoma preoperatively. Histopathological examination of the excised tumor showed spindle-shaped or stellate cells embedded in the myxoid matrix, and a few small irregular clusters of mature fat cells that are separated by connective tissue septa. There were some immature, lipoblast-like cells dispersed. These findings are consistent with lipoblastoma, and myxoid liposarcoma was considered as one of the differential diagnosis. We finally diagnosed the tumor as a lipoblastoma for the reasons that there were many mature fat cells and no atypical cells for a myxoid liposarcoma. The postoperative course was uneventful and no recurrence was observed 5 years after the operation. The patient presented is worthy of note due to the unusual characteristics of the tumor. Even in the case of adolescent or older patients with atypical imaging, lipoblastoma should be considered as one of differential diagnosis.Keywords: lipoblastoma; neoplasm; magnetic resonance imaging; adipose tumor; soft tissue tumor Tohoku J. Exp. Med., 2011, 223 (1), 75-78. © 2011 Tohoku University Medical Press Lipoblastoma is a rare benign soft-tissue childhood tumor occurring most commonly in children less than 3 years of age (Chung and Enzinger 1973;Mentzel et al. 1993), and magnetic resonance image (MRI) is a useful tool for its diagnosis and preoperative evaluation (Reiseter et al. 1999). MRIs of this type of tumor are typically characterized by high-intensity signals on both T1 weighted (T1-W) and T2 weighted (T2-W) images (Letourneau et al. 1993). We report a 12-year-old female patient with lipoblastoma in the shoulder, which was difficult to diagnose preoperatively because of the age and its atypical MRI findings. Meanwhile, the presented tumor showed generally low-intensity signals on T1-W, and high-intensity signals on T2-W images. These findings were not consistent with lipomatous tumor, and finally we made a diagnosis considering all findings obtained. Clinical FindingsA 12-year-old female was referred to our clinic with a 3-month history of a painless mass on the anterior right shoulder. The patient had no history of trauma or constitutional symptoms. Physical examination showed a 6 × 3 cm elastic soft mass on the anteromedial aspect of the right humerus. The mass was non-tender, well circumscribed, and distinct from surrounding tissue, and did not pulsate. The overlying skin showed none of reddening, increased warmth and vein distention...

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“…-A fatty component is suggestive of a benign lesion such as lipoblastoma (Fig. 9) [15], fibrolipomatous hamartoma, lipoma or dermoid cyst since liposarcomas are exceptional and generally not observed before the age of 10 years [3]. Therefore, in childhood, when fatty lesions are observed, a morphologic characterization by magnetic resonance may be a sufficient basis on which to make critical therapeutic judgments [32].…”

Section: How To Analyze the Images?mentioning

confidence: 99%

“…5). More rarely, demonstration of bone hypertrophy may indicate an arteriovenous malformation or diffuse lipomatosis [15]. Analysis of soft tissues must look for calcifications and fat density areas.…”

Section: Conventional Radiographymentioning

confidence: 99%

Imaging and diagnostic strategy of soft tissue tumors in children

et al. 2006

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The diagnosis of a soft tissue mass in children is a common clinical situation. Most of the lesions are benign and can be treated conservatively or by non-mutilating surgery. Nevertheless, the possibility of a malignant soft tissue tumor must be systematically considered. The most frequent benign soft tissue lesions in children are vascular lesions, fibrous and fibrohistiocytic tumors and pseudotumors, whereas rhabdomyosarcomas account for 50% of all soft tissue sarcomas. A child presenting an atypical soft tissue mass should be managed by a multidisciplinary centre, and primary resection must be proscribed until a definite diagnosis has been established. The role of imaging is essential either to confirm the benign nature of the mass or to give arguments to perform a diagnostic biopsy. Clinical examination, conventional radiography and ultrasound with Doppler represent the first-line examinations and are sometimes sufficient to assess a diagnosis. In all other situations, MRI is mandatory to establish the probable nature of the lesion and to assess local extension.

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Lipoblastoma: MRI appearances of a rare paediatric soft tissue tumour

Cited by 66 publications

References 3 publications

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Lipoblastoma Mimicking Myxoid Liposarcoma: A Clinical Report and Literature Review

Imaging and diagnostic strategy of soft tissue tumors in children

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