Lipoblastoma in infancy and childhood

Jimenez, Jorge F.

doi:10.1002/jso.2930320413

Cited by 71 publications

(27 citation statements)

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“…3 Some of them are small and round, with a single, vacuolelike fat droplet with a signet ring appearance, and others may be larger, round or polyhedral, with round or notched nuclei compressed by many vacuoles ( Figure 4C). Floret cells-similar to those of pleomorphic lipoma 2 ; scattered, hibernomalike, eosinophilic cells with multiple small vacuoles within the cytoplasm 3,33 ; foci of chondroid metaplasia 3 ; extramedullary hematopoiesis 3 ; and chronic inflammation 3,6 -are additional findings. The myxoid stroma contains abundant hyaluronic acid, which may form pools and cystic lakes of mucin and myxoid hypocellular areas.…”

Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Leon

Deschler

et al. 2002

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Leon

Deschler

et al. 2002

Acta Cytologica

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“…However, liposarcoma in children under 10 years of age is extremely rare (12). Also, lipoblastomatosis usually has distinct lobulation and lacks cellular atypia and bizarre mitoses (9).…”

Section: Discussionmentioning

confidence: 99%

Congenital Lipoblastomatosis of the Lower Extremity in a Neonate

Calobrisi¹,

Garland²,

Esterly³

1998

Pediatric Dermatology

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“…It has a good prognosis, and does not behave aggressively or metastasize, and therefore the treatment of choice is complete but conservative excision (Chung and Enzinger 1973;Mentzel et al 1993;Coffin 1994;Gilbert et al 1996). This type of tumor is rare in patients older than 8 years, however, it has been reported in a number of patients over 10 years of age (Reinders et al 1983;Jimenez 1986;Gisselsson et al 2001). In the present report, the patient was 12 years old and was considered relatively old for the condition, and hence it was considered to be rare.…”

Section: Discussionmentioning

confidence: 99%

Lipoblastoma Mimicking Myxoid Liposarcoma: A Clinical Report and Literature Review

Nagano

Ohno

Nishimoto

et al. 2011

Tohoku J. Exp. Med.

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Lipoblastoma is an uncommon benign lipomatous tumor, occurring typically in children less than 3 years of age. The magnetic resonance image (MRI) is a useful tool for diagnosis of lipoblastoma; its imaging typically shows high-intensity signals on both T1-weighted (T1-W) and T2 weighted (T2-W) images. Here, we present a 12-year-old female patient with a painless mass on the anterior right shoulder. MRI showed the mass with low-intensity signals on T1-W and high-intensity signals on T2-W images. Because of the atypical age and MRI findings, it was difficult to make a conclusive diagnosis of the tumor as lipoblastoma preoperatively. Histopathological examination of the excised tumor showed spindle-shaped or stellate cells embedded in the myxoid matrix, and a few small irregular clusters of mature fat cells that are separated by connective tissue septa. There were some immature, lipoblast-like cells dispersed. These findings are consistent with lipoblastoma, and myxoid liposarcoma was considered as one of the differential diagnosis. We finally diagnosed the tumor as a lipoblastoma for the reasons that there were many mature fat cells and no atypical cells for a myxoid liposarcoma. The postoperative course was uneventful and no recurrence was observed 5 years after the operation. The patient presented is worthy of note due to the unusual characteristics of the tumor. Even in the case of adolescent or older patients with atypical imaging, lipoblastoma should be considered as one of differential diagnosis.Keywords: lipoblastoma; neoplasm; magnetic resonance imaging; adipose tumor; soft tissue tumor Tohoku J. Exp. Med., 2011, 223 (1), 75-78. © 2011 Tohoku University Medical Press Lipoblastoma is a rare benign soft-tissue childhood tumor occurring most commonly in children less than 3 years of age (Chung and Enzinger 1973;Mentzel et al. 1993), and magnetic resonance image (MRI) is a useful tool for its diagnosis and preoperative evaluation (Reiseter et al. 1999). MRIs of this type of tumor are typically characterized by high-intensity signals on both T1 weighted (T1-W) and T2 weighted (T2-W) images (Letourneau et al. 1993). We report a 12-year-old female patient with lipoblastoma in the shoulder, which was difficult to diagnose preoperatively because of the age and its atypical MRI findings. Meanwhile, the presented tumor showed generally low-intensity signals on T1-W, and high-intensity signals on T2-W images. These findings were not consistent with lipomatous tumor, and finally we made a diagnosis considering all findings obtained. Clinical FindingsA 12-year-old female was referred to our clinic with a 3-month history of a painless mass on the anterior right shoulder. The patient had no history of trauma or constitutional symptoms. Physical examination showed a 6 × 3 cm elastic soft mass on the anteromedial aspect of the right humerus. The mass was non-tender, well circumscribed, and distinct from surrounding tissue, and did not pulsate. The overlying skin showed none of reddening, increased warmth and vein distention...

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Lipoblastoma in infancy and childhood

Cited by 71 publications

References 13 publications

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Congenital Lipoblastomatosis of the Lower Extremity in a Neonate

Lipoblastoma Mimicking Myxoid Liposarcoma: A Clinical Report and Literature Review

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