Lipoblastoma: A Case with t(7;8)(q31;q13)

Panarello, Claudio; Rosanda, Cristina; Morerio, Cristina; Russo, Ivana; Dallorso, Sandro; Gambini, Claudio; Ricco, Angela; Storlazzi, T.; Archidiacono, Nicoletta; Rocchi, Mariano

doi:10.1016/s0165-4608(97)00272-0

Cited by 22 publications

(15 citation statements)

References 11 publications

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“…Two cases of chondroid lipoma with seemingly identical t(11;16)(q13;p13) have also been described [12,47], suggesting that this abnormality may be specific for this recently described pseudosarcomatous tumor [14,29]. Finally, structural rearrangements involving 11q13-21 and 8q11-13 are nonrandom changes in hibernomas [21,25,28] and lipoblastomas [36], respectively.…”

Section: Introductionmentioning

confidence: 98%

Cytogenetic and molecular genetic analyses of liposarcoma and its soft tissue simulators: recognition of new variants and differential diagnosis

et al. 2001

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Liposarcoma is one of the most common sarcomas of adults. Its differential diagnosis and accurate subclassification are often problematic; the latter is also important with regard to appropriate treatment and prognosis. We studied a series of 23 liposarcomas that had unusual or previously undescribed features and 10 liposarcoma simulators and correlated the morphologic, cytogenetic, and molecular genetic findings. We found that use of cytogenetic-molecular genetic techniques aids in the distinction between myxoid-round cell liposarcoma and their simulators, chondroid lipoma, myxoid spindle cell-pleomorphic lipoma, cellular intramuscular myxoma, and myxofibrosarcoma. Poorly differentiated forms of round cell liposarcoma lacking morphologic evidence of lipogenesis can also be diagnosed using these techniques; however, the techniques do not aid in distinguishing low-grade myxoid from high-grade round cell liposarcomas. This study also shows that retroperitoneal liposarcomas with myxoid liposarcoma-like zones are part of the morphologic spectrum of well-differentiated-dedifferentiated liposarcoma rather than true myxoid liposarcomas. Perhaps most importantly, our results provide the first molecular genetic evidence that true mixed liposarcomas (mixed well-differentiated and myxoid liposarcoma) do indeed exist. They also unequivocally demonstrate the existence of small, round cell variants of pleomorphic liposarcoma that closely simulate myxoid-round cell liposarcoma.

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Section: Introductionmentioning

confidence: 98%

Cytogenetic and molecular genetic analyses of liposarcoma and its soft tissue simulators: recognition of new variants and differential diagnosis

et al. 2001

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“…42 In FNA specimens, FISH may be applied to diagnose the specific chromosome 8 translocation of lipoblastoma and can rapidly establish a diagnosis. 44 Lipoma and fibrolipoma may resemble lipoblastoma when fibrous septa are prominent, but both lipoma and fibrolipoma lack lipoblasts in cytologic specimens and histologic sections. 15 Hibernoma has a uniform, characteristic appearance and also lacks lipoblasts.…”

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confidence: 99%

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Leon

Deschler

et al. 2002

Acta Cytologica

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“…The malignancy arises from the continued proliferation of lipoblasts after birth and can be divided into a well circumscribed form called lipoblastoma and a more diffuse and infiltrative form called lipoblastomatosis [2,3,8,9]. While both tumors are considered benign, complete surgical excision is the recommended treatment given the 14-25 % incidence of recurrence [2,4,10].…”

Section: Discussionmentioning

confidence: 99%

“…The first karyotype for lipoblastoma was reported by Sandberg in 1986 and since then several other case reports have been published helping to illustrate the connection between lipoblastoma and chromosome 8 [3,8,9,12,14]. The typical chromosome abnormality associated with lipoblastoma is a translocation involving the 8q11-q13 region, which has recently been discovered to encompass the oncogene pleomorphic adenoma gene 1 (PLAG1) [4,11,15,16].…”

Section: Discussionmentioning

confidence: 99%

A novel t(3;8)(p13;q21.1) translocation in a case of lipoblastoma

et al. 2012

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Lipoblastoma is a rare benign neoplasm of embryonic white fatty tissue primarily found in the extremities of children <3 years old (Batanian et al., Cancer Genet Cytogenet 125(1):10-13, 2001; McVay MR et al., J Pediatr Surg 41(6):1067-1071, 2006; Kamal et al., J Pediatr Surg 46(7):E9-E12, 2011). Translocations affecting the 8q11-13 region are commonly reported with lipoblastoma and proper diagnosis requires cytogenetic analysis to distinguish it from malignant myxoid liposarcoma (Miller et al., J Pediatr Surg 32(12):1771-1772, 1997; Morerio et al., Pediatr Blood Cancer 52(1):132-134, 2009). We describe an additional case of lipoblastoma containing a new translocation t(3;8)(p13;q21.1), which has not previously been reported in a healthy asymptomatic child.

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Lipoblastoma: A Case with t(7;8)(q31;q13)

Cited by 22 publications

References 11 publications

Cytogenetic and molecular genetic analyses of liposarcoma and its soft tissue simulators: recognition of new variants and differential diagnosis

Cytogenetic and molecular genetic analyses of liposarcoma and its soft tissue simulators: recognition of new variants and differential diagnosis

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

A novel t(3;8)(p13;q21.1) translocation in a case of lipoblastoma

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