Lipoastrocytoma: Case report and review of the literature

Gheri, Chiara Francesca; Buccoliero, Anna Maria; Pansini, Gastone; Castiglione, Francesca; Garbini, Francesca; Moncini, Daniela; Maccari, Chiara; Mennonna, P; Pellicanò, G.; Ammannati, Franco; Taddei, Gian Luigi

doi:10.1111/j.1440-1789.2009.01096.x

Cited by 6 publications

(15 citation statements)

References 28 publications

(47 reference statements)

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“…Adipose, cartilaginous and osseous metaplasia were also reported in cases of choroid plexus papilloma . Furthermore, lipomatous transformation of neuroectodermal tumor cells has been previously observed in neurocytomas, medulloblastomas, cerebellar and spinal cord astrocytomas, and primitive neuroectodermal tumors …”

Section: Discussionmentioning

confidence: 79%

Pituitary adenoma with adipose tissue: A new metaplastic variant

et al. 2017

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Pituitary adenomas are benign tumors representing approximately 15-20% of intracranial neoplasms. There have been few reports of metaplastic osseous transformation and about 60 cases of neuronal metaplasia in pituitary adenoma but adipose metaplasia has not been previously described in the English literature. Here we report a case of pituitary adenoma with metaplastic adipose tissue in a 58-year-old male patient. Histologically this case fulfilled the criteria of a non-functioning pituitary adenoma, and moreover a central area of adipose tissue, made by mature adipocytes, and many tumor cells, containing fat droplet were evident. Lipomatous transformation of tumor cells in the CNS has been previously observed but, to the best of our knowledge, our case is the first pituitary adenoma with such change. The histogenesis of the adipose element in pituitary adenoma is not well understood, and could be a result of a metaplastic change or divergent differentiation from a common progenitor cell.

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Section: Discussionmentioning

confidence: 79%

Pituitary adenoma with adipose tissue: A new metaplastic variant

et al. 2017

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“…Thoracic intramedullary astrocytoma with lipidization was described in a 36-year-old patient by Aryan et al 9 Complex partial seizure secondary to lipoastrocytoma was reported. 18 Lipoastrocytoma of the fourth ventricle in an adult male was reprted by Lee et al 15 Gheri et al 11 described a case of cerebellar lipoastrocytoma in a 39-year-old man. Two pediatric cases were described by Massimi et al 19 and Craver et al 20 in the frontal cortex and pons, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of lipomatous change in neuroectodermal tumors is unclear. It has been described in three groups of disorders: hamartomas, primary neoplasm and metastasis . The proposed mechanisms include a disturbance in cellular metabolism, a divergent differentiation of precursor cells into astrocytic and fat cells, or a true adipose metaplasia.…”

Section: Discussionmentioning

confidence: 99%

“…Lipoastrocytoma of the fourth ventricle in an adult male was reprted by Lee et al . Gheri et al . described a case of cerebellar lipoastrocytoma in a 39‐year‐old man.…”

Section: Discussionmentioning

confidence: 99%

“…It has been described in three groups of disorders: hamartomas, primary neoplasm and metastasis. 11 The proposed mechanisms include a disturbance in cellular metabolism, 2 a divergent differentiation of precursor cells into astrocytic and fat cells, 12 or a true adipose metaplasia. Owing to the fact that the lipidladen cells retain the immunophenotype of the nonlipidized tumor cells (GFAP positivity) and exhibit a glial nature by ultrastructure, the most plausible explanation for lipidization would be a degenerative/metabolic change rather than a form of metaplasia or differentiation along multiple different lines.…”

Section: Discussionmentioning

confidence: 99%

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Lipoastrocytoma: A rare case report and review of literature

Sharma

Khurana

2014

Neuropathology

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Lipoastrocytoma is an extremely rare tumor, with only a few cases described. We report a case of a low-grade astrocytoma occupying the right cortical lobe in the parafalcine location. The patient was admitted with headache, vomiting and altered sensorium for duration of 1 year. MRI revealed a large heterogeneous enhancing mass in the right fronto-parieto-temporal lobe with intratumoral fat along with cystic changes and calcification (correlated with CT) showing mass effect in the third ventricle. A gross total excision of the tumor was performed. Histologically, the tumor showed glial cells that contained lipid droplets coalescing into a single large droplet, similar in appeareance to adipocytes. Immunohistocemically, tumor cells strongly expressed GFAP and S-100 protein. Ki-67 labelling index was low. The patient remained in good neurological condition at 3 months follow-up. This case represents a rare variant of low-grade astrocytoma that is designated as lipoastrocytoma.

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Unclassified glioneuronal tumor with advanced lipidization

et al. 2011

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Lipidization is observed only occasionally in primary neuroectodermal tumors of the central nervous system. It may reflect lipomatous transformation of tumor cells into xanthomatous and/or adipocyte-like cells. We report a unique case of mixed glioneuronal tumor with marked lipomatous changes in a young patient with intractable epilepsy. MRI revealed a well-circumscribed lesion in the right temporal lobe. Histopathological findings showed the pleomorphic tumor with numerous cells containing large lipid droplets, resembling mature adipocytes, that were arranged in clusters or scattered within the neoplastic tissue. The tumor was composed of both glial and neuronal elements. Some tumor cells displayed features intermediate between glial and neuronal cells. The reticulin fibers were limited to blood vessels. Mitotic figures, vascular proliferation, and necrosis were absent, and MIB-1 labeling index was less than 1%. Diffuse immunoreactivity for GFAP and S100-protein was observed. In some heavily lipidized cells, the lipid droplets were surrounded by a cytoplasmic rim of GFAP immunoreactivity. Numerous cells exhibited immunostaining for NSE and synaptophysin. This is the first documented case of glioneuronal tumor with extensive lipomatous transformation, which might be considered as a heavily lipidized unclassified pleomorphic glioneuronal tumor or a variant of lipoganglioglioma with marked pleomorphism and severe lipidization.

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Lipoastrocytoma: Case report and review of the literature

Cited by 6 publications

References 28 publications

Pituitary adenoma with adipose tissue: A new metaplastic variant

Pituitary adenoma with adipose tissue: A new metaplastic variant

Lipoastrocytoma: A rare case report and review of literature

Unclassified glioneuronal tumor with advanced lipidization

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