Lipin Family Proteins - Key Regulators in Lipid Metabolism

Abstract

Background: Proteins in the lipin family play a key role in lipid synthesis due to their phosphatidate phosphatase activity, and they also act as transcriptional coactivators to regulate the expression of genes involved in lipid metabolism. The lipin family includes three members, lipin1, lipin2, and lipin3, which exhibit tissue-specific expression, indicating that they may have distinct roles in mediating disease. To date, most studies have focused on lipin1, whereas the roles of lipin2 and lipin3 are less understood. Summary: This review introduces the structural characteristics, physiological functions, relationship to lipid metabolism, and patterns of expression of the lipin family proteins, highlighting their roles in lipid metabolic homeostasis. © 2014 S. Karger AG, Basel

The Nem1/Spo7–Pah1/lipin axis is required for autophagy induction after TORC1 inactivation

“…Lipin is a key enzyme as a branch in the biogenesis of membrane lipids and storage lipids . TORC1 attenuates this pathway in normal conditions, and TORC1 inactivation switches on this pathway; namely, TORC1 promotes the biogenesis of membrane lipids in normal conditions and the biogenesis of storage lipids in nutrient‐starved conditions .…”

“…Phosphatidate (PA) phosphatase, known as lipin, generates diacylglycerol (DAG) from PA and is a key enzyme for the synthesis of membrane phospholipids and triacylglycerol (TAG) as a neutral lipid reserve . Lipin is essential for fat metabolism, adipogenesis, and organelle biogenesis in mammals .…”

Targeted Lipidomics of Fontal Cortex and Plasma Diacylglycerols (DAG) in Mild Cognitive Impairment and Alzheimer’s Disease: Validation of DAG Accumulation Early in the Pathophysiology of Alzheimer’s Disease

“…4). As a part of these investigations, we also need to assess lipin family proteins which are key regulators in lipid metabolism both as phosphatidic acid phosphatases and as transcriptional co-activators regulating the expression of genes involved in lipid metabolism [47–48]. In this regard, lipin 1γ is highly expressed in human brain [48].…”

Nonalcoholic fatty liver disease in patients with psoriasis: a consequence of systemic inflammatory burden?

“…Several candidate genes have been evaluated with a hypothesis‐driven approach. For example, some genes linked to NAFLD are related to lipid metabolism [hepatic lipase and lipin‐1 ( LPIN1) , regulation of triglyceride levels; peroxisome proliferator‐activated receptor, glucose and lipid metabolism regulation; microsomal triglyceride transfer protein, phospholipid and triglyceride development; and phosphatidylcholine, hepatic formation and secretion of very‐low‐density lipoproteins) and fibrogenesis (TGF‐β1, angiotensinogen, angiotensin receptors) or encode cytokines/adipocytokines (TNF‐α, leptin, adiponectin)] …”