Lipids of Geochemical Interest in Microalgae

Volkman, John K.

doi:10.1007/978-3-319-90569-3_10

Cited by 3 publications

(9 citation statements)

References 187 publications

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Section: Introductionmentioning

confidence: 95%

“…Sulfate is generally readily available in aquatic ecosystems for many marine and freshwater organisms [ 1 , 2 , 3 , 4 , 9 , 10 , 14 , 18 , 20 , 23 , 24 , 25 , 26 , 27 ]. The biochemistry and geochemistry of sulfur are currently well studied, and many publications are devoted to this topic [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , …”

Section: Introductionmentioning

confidence: 99%

“…Studies of the last decades of marine sediments have shown that extracts from these geological formations contain a wide variety of steroids, terpenoids, and other lipids [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. These findings indicate that such a variety of lipids is of organic origin, and, apparently, the producers are bacteria, terrestrial higher plants, unicellular and diatom algae, marine invertebrates, and other organisms [ 22 , 23 , 30 ]. Interestingly, sterols, triterpenoids, and even boron-containing compounds were found in marine sediments of the Cretaceous period more than 150 million years ago [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

“…Many photosynthetic organisms such as algae and phytoplankton assimilate sulfur as sulfate. Sulfate is generally readily available in aquatic ecosystems for many marine and freshwater organisms [1][2][3][4]9,10,14,18,20,[23][24][25][26][27]. The biochemistry and geochemistry of sulfur are currently well studied, and many publications are devoted to this topic [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

et al. 2021

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The review focuses on sulfated steroids that have been isolated from seaweeds, marine sponges, soft corals, ascidians, starfish, and other marine invertebrates. Sulfur-containing steroids and triterpenoids are sourced from sedentary marine coelenterates, plants, marine sediments, crude oil, and other geological deposits. The review presents the pharmacological profile of sulfated steroids, sulfur-containing steroids, and triterpenoids, which is based on data obtained using the PASS program. In addition, several semi-synthetic and synthetic epithio steroids, which represent a rare group of bioactive lipids that have not yet been found in nature, but possess a high level of antitumor activity, were included in this review for the comparative pharmacological characterization of this class of compounds. About 140 steroids and triterpenoids are presented in this review, which demonstrate a wide range of biological activities. Therefore, out of 71 sulfated steroids, thirteen show strong antitumor activity with a confidence level of more than 90%, out of 50 sulfur-containing steroids, only four show strong antitumor activity with a confidence level of more than 93%, and out of eighteen epithio steroids, thirteen steroids show strong antitumor activity with a confidence level of 91% to 97.4%.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

et al. 2021

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“…Steroids are de facto isoprenoid lipids and are found in eukaryotic organisms, from microorganisms to macroalgae, invertebrates, and plants, and are present in most sedimentary organic matter [1][2][3][4][5][6][7][8]. Thus, steroids and isoprenoid lipids are an important group of fossil chemical compounds that provide valuable information about the sources of organic matter in modern sediments and ancient sedimentary rocks, as well as crude oil [9][10][11][12]. Diagenesis of organic matter found in waters and sediments modifies the structures of steroid precursors in complex ways.…”

Section: Introductionmentioning

confidence: 99%

Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Dembitsky

2024

Biomedicines

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The main focus of this review is to introduce readers to the fascinating class of lipid molecules known as norsteroids, exploring their distribution across various biotopes and their biological activities. The review provides an in-depth analysis of various modified steroids, including A, B, C, and D-norsteroids, each characterized by distinct structural alterations. These modifications, which range from the removal of specific methyl groups to changes in the steroid core, result in unique molecular architectures that significantly impact their biological activity and therapeutic potential. The discussion on A, B, C, and D-norsteroids sheds light on their unique configurations and how these structural modifications influence their pharmacological properties. The review also presents examples from natural sources that produce a diverse array of steroids with distinct structures, including the aforementioned A, B, C, and D-nor variants. These compounds are sourced from marine organisms like sponges, soft corals, and starfish, as well as terrestrial entities such as plants, fungi, and bacteria. The exploration of these steroids encompasses their biosynthesis, ecological significance, and potential medical applications, highlighting a crucial area of interest in pharmacology and natural product chemistry. The review emphasizes the importance of researching these steroids for drug development, particularly in addressing diseases where conventional medications are inadequate or for conditions lacking sufficient therapeutic options. Examples of norsteroid synthesis are provided to illustrate the practical applications of this research.

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Naturally Occurring Nor-Steroids and Their Design and Pharmaceutical Application

Dembitsky

2024

Preprint

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The main focus of this review is to introduce readers to the fascinating class of lipid molecules known as norsteroids, exploring their distribution across various biotopes and their biological activities. The review provides an in-depth analysis of various modified steroids, including A, B, C, and D-norsteroids, each characterized by distinct structural alterations. These modifications, which range from the removal of specific methyl groups to changes in the steroid core, result in unique molecular architectures that significantly impact their biological activity and therapeutic potential. The discussion on A, B, C, and D-norsteroids sheds light on their unique configurations and how these structural modifications influence their pharmacological properties. The review also presents examples from natural sources that produce a diverse array of steroids with distinct structures, including the aforementioned A, B, C, and D-nor variants. These compounds, sourced from marine organisms like sponges, soft corals and starfish, as well as terrestrial entities such as plants, fungi, and bacteria. The exploration of these steroids encompasses their biosynthesis, ecological significance, and potential medical applications, highlighting a crucial area of interest in pharmacology and natural product chemistry. The review emphasizes the importance of researching these steroids for drug development, particularly in addressing diseases where conventional medications are inadequate or for conditions lacking sufficient therapeutic options. Examples of norsteroid synthesis are provided to illustrate the practical applications of this research.

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Lipids of Geochemical Interest in Microalgae

Cited by 3 publications

References 187 publications

Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Naturally Occurring Nor-Steroids and Their Design and Pharmaceutical Application

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