Lipids and Warfarin Requirements

Robinson, Amy L.; Liau, F O; Routledge, PA; Backhouse, G; Spragg, B.P.; Bentley, D P

doi:10.1055/s-0038-1645708

Cited by 3 publications

(2 citation statements)

References 3 publications

(3 reference statements)

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“…20 This most likely results in a decreased pool of vitamin K, some of which is bound to triglycerides. 21 Conversely, patients receiving intravenous lipids with total parenteral nutrition have also been diagnosed clinically with warfarin resistance, 22 and rat models have shown an association between a lipidrich diet and increased vitamin K-dependent factor activity. 23 Diuretics may decrease the response to warfarin by reducing the plasma volume, with a subsequent increase in clotting factor activity.…”

Section: Pharmacokinetic Resistancementioning

confidence: 99%

An algorithm for managing warfarin resistance

Osinbowale

Malki

Schade

et al. 2009

CCJM

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Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.

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Section: Pharmacokinetic Resistancementioning

confidence: 99%

An algorithm for managing warfarin resistance

Osinbowale

Malki

Schade

et al. 2009

CCJM

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“…Oestrogens, griseofulvin, 6‐mercaptopurine and haloperidol may cause diminution of anticoagulant effect in some individuals, although the mechanisms are poorly understood [1]. Patients with hyperlipidaemia (particularly hypercholesterolaemia may be relatively resistant to warfarin [2, 3] and although the effect appears to have a pharmacodynamic basis [3], the cause is unknown. Finally, an extremely rare form of hereditary warfarin resistance has been described in two human kindreds [4, 5].…”

Section: Case Reportmentioning

confidence: 99%

Case studies in therapeutics: warfarin resistance and inefficacy in a man with recurrent thromboembolism, and anticoagulant‐associated priapism

Routledge

Shetty

White

et al. 1998

Brit J Clinical Pharma

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[4, 5]. The trait is inherited in an autosomal dominant fashion and a mutation of the receptor site shared by meal and enema, and CT of the thorax, abdomen and pelvis, bronchoscopy and brushings also failed to reveal any abnormality.warfarin and vitamin K is postulated, although the locus of the mutation is unknown. He was commenced on full-dose ( porcine mucosal) heparin for 10 days and the warfarin dose was increased to 15 mg daily untilMeasurement of the plasma warfarin concentration may be helpful in all these circumstances, since at steady state, his INR had risen to 4.0, when his plasma warfarin concentration was measured at 3.1 mg l −1 . the reference range is 0.8 to 2.4 mg l −1 [6]. The reference range for warfarin clearance (calculated by dividing the daily Patients vary markedly in their requirement for warfarin, warfarin dose by the steady-state plasma concentration) is but 95% of subjects need more than 1 and less than 2.5 to 8.7 l day −1

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A Guide to Oral Anticoagulant Therapy

Palareti¹

1998

Pathophysiol Haemos Thromb

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Lipids and Warfarin Requirements

Cited by 3 publications

References 3 publications

An algorithm for managing warfarin resistance

An algorithm for managing warfarin resistance

Case studies in therapeutics: warfarin resistance and inefficacy in a man with recurrent thromboembolism, and anticoagulant‐associated priapism

A Guide to Oral Anticoagulant Therapy

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