Lipids and thyroid hormones

Hoch, Frederic L.

doi:10.1016/0163-7827(88)90013-6

Cited by 144 publications

(81 citation statements)

References 536 publications

(21 reference statements)

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“…These studies indicated that freshwater upstream migrants and adults of anadromous parasitic lampreys, which have a feeding juvenile phase on freshwater or seawater teleost fish flesh, showed considerable amount of 22:6v3 and the marine type of teleost fatty acids, such as higher v3yv6 PUFA ratio. In anurans, alterations in hepatic fatty acid compositions also have been reported to accompany the metamorphosis of aqueous herbivore tadpoles to terrestrial carnivore frog (Hoch, 1988). Decreased monoenes and increased polyunsaturated fatty acids were observed during amphibian metamorphosis (Hoch, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…In anurans, alterations in hepatic fatty acid compositions also have been reported to accompany the metamorphosis of aqueous herbivore tadpoles to terrestrial carnivore frog (Hoch, 1988). Decreased monoenes and increased polyunsaturated fatty acids were observed during amphibian metamorphosis (Hoch, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…thermal) and physiological (e.g. hormonal) cues (Henderson and Tocher, 1987;Hoch, 1988). Changes in fatty acid compositions from the plasma, whole body, andyor tissues (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Differences in the fatty acid composition of larvae and metamorphosing sea lampreys, Petromyzon marinus

Kao

Youson

Vick

et al. 2002

Comparative Biochemistry and Physiology Part B: Biochemistry an

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This study was designed to evaluate biochemical changes in the fatty acid (FA) compositions of selected lipid depot (kidney and liver) and absorption (intestine) organs in larvae and metamorphosing sea lamprey, Petromyzon marinus. Palmitic or stearic acids were generally the predominant saturated fatty acids (SFA) before and during metamorphosis, but the greatest proportion of myristic acid occurred in renal triacylglycerol (TG). Monoenes, dienes, and polyenes consist mainly of 16:1, 18:1, and 20:1, 18:2 and 20:2v6, and 18:4v3, respectively. Alterations in these predominant fatty acids occurred during lamprey metamorphosis, but depended on tissue, lipid class, and developmental status. During metamorphosis, kidney TG and phospholipid (PL) classes tended to mobilize SFA and enhance the fatty acid unsaturation, as indicated by increased unsaturatedysaturated ratio, unsaturation index (USI), and total mean chain length (MCL). There was a tendency to increase saturation in the fatty acids of liver TG and PL classes and intestine TG, FA and monoacylglycerol (MG) classes, but to increase unsaturation in the fatty acids of liver cholesteryl ester (CE), FA and MG classes and intestine PL and CE classes from larva or stage 3 to stage 7. Increased polyunsaturated fatty acids in kidney TG and PL from larvae to stage 5 transformers and intestine PL and CE from stage 3 to stage 7 transformers may reflect an osmoregulatory pre-adaptation. The presence of branched-chain SFA (BCSFA) and the odd number of fatty acids (ONFA) indicated a significant role of detritivores in the benthic larvae. Decreased abundance of BCSFA, ONFA, and 18:2 dienes occurred in the transformed intestine TG as non-trophic metamorphosis proceeded. These data suggest that sea lamprey metamorphosis may proceed in a habitat, dietary, osmoregulatory, energetic, and developmental pre-adaptation of fatty acid composition from benthic filter-feeding larvae to pelagic parasitic juveniles. ᮊ

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Differences in the fatty acid composition of larvae and metamorphosing sea lampreys, Petromyzon marinus

Kao

Youson

Vick

et al. 2002

Comparative Biochemistry and Physiology Part B: Biochemistry an

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“…Thyroid hormones affect reactions in almost all pathways of lipid metabolism (Hoch 1988). Plasma free fatty acid (FFA) is released from triglyceride-rich lipoprotein by lipoprotein lipase and hepatic triglyceride lipase.…”

Section: Introductionmentioning

confidence: 99%

Effect of eicosapentaenoic acid ethyl ester on hypothyroid function

Miyamoto¹,

Oda²,

Miura³

et al. 2001

Journal of Endocrinology

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Thyroid hormones affect reactions in almost all pathways of lipid metabolism. It has been reported that plasma free fatty acid (FFA) concentration in hypothyroidism is generally within the normal range. In this study, however, we show that plasma FFA concentration in some hypothyroid patients is higher than the normal range. Symptoms of thyroid dysfunction in these individuals were less severe than those of patients with lower plasma FFA concentrations. From these findings we hypothesized that the change in FFA concentration must correlate with thyroid function. Using an animal model, we then examined the effect of highly purified eicosapentaenoic acid ethyl ester (EPA-E), a n-3 polyunsaturated fatty acid derived from fish oil, on thyroid function in 1-methyl-2-imidazolethiol (MMI)-induced hypothyroid rats. Oral administration of EPA-E inhibited reduction of thyroid hormone levels and the change of thyroid follicles in MMI-induced hypothyroid rats. These findings suggest that FFA may affect thyroid functions and EPA-E may prevent MMI-induced hypothyroidism.

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“…Thyroid disorders influence lipoprotein metabolism (1)(2)(3). Changes in plasma cholesterol concentrations are primarily due to changes in the low-density lipoprotein (LDL) fraction.…”

Section: Introductionmentioning

confidence: 99%

Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

2016

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Objectives: This study aimed to measure lipoprotein (a) [Lp(a)], lipid profile and mean platelet volume (MPV) in hypothyroid patients compared to healthy controls.Methods: An unmatched case-control study was conducted involving 100 subjects (50 overt hypothyroidism patients and 50 healthy controls admitted to the University of Science and Technology Hospital, Al-Thawra Hospital and Al-Jomhori Hospital-Sana'a, Yemen during the period from May 2013 to March 2014. Data were collected by in-person interview using a structured questionnaire followed by weight and height measurements. Fresh blood samples were collected and analyzed using electrochemiluminescent, spectrophotometric and immunoturbidimetric methods for estimating Lp(a), lipid profile and MPV parameters. Results:Hypothyroid patients had a significantly higher concentration of Lp(a) compared to the control. Total cholesterol (TC), triglycerides and low-density lipoprotein-cholesterol (LDL-C) levels were also significantly higher in hypothyroid patients. Serum level of free triiodothyronine (FT3) was negatively correlated with Lp(a), p=0.007; p=0.012; p=0.013, respectively). However, serum thyroid-stimulating hormone was positively correlated with Lp(a), p=0.015; r=0.299, p=0.035; r=0.405, p=0.004, respectively) among hypothyroid patients. MPV levels, on the other hand, showed a strong positive correlation with (r=0.611, p=0.001). Conclusions:These findings indicate that overt hypothyroidism patients tend to have increased Lp(a) and atherogenic lipids that may contribute to increasing risk of atherosclerosis. However, hypothyroid patients showed no significant difference compared to the controls regarding the MPV

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Lipids and thyroid hormones

Cited by 144 publications

References 536 publications

Differences in the fatty acid composition of larvae and metamorphosing sea lampreys, Petromyzon marinus

Differences in the fatty acid composition of larvae and metamorphosing sea lampreys, Petromyzon marinus

Effect of eicosapentaenoic acid ethyl ester on hypothyroid function

Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

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