Lipids and lipoproteins predicting coronary heart disease mortality and morbidity in patients with non-insulin-dependent diabetes.

Laakso, Markku; Lehto, Seppo; Penttilä, Ilkka; Pyörälà, Kalevi

doi:10.1161/01.cir.88.4.1421

Cited by 274 publications

(140 citation statements)

References 52 publications

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“…1,4 The prevalence of hypertriglyceridemia is three times higher in men with type 2 diabetes compared to men with normal glucose tolerance, 28 and high total and VLDL triglycerides are independent and powerful predictors of CHD in type 2 diabetes. 4,5 Indeed, type 2 diabetic patients with serum triglycerides above 2.3 mmolal have a 2-fold increased risk of CHD.…”

Section: Discussionmentioning

confidence: 99%

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Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes

et al. 2001

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OBJECTIVE:To investigate the effect of an exercise training program on lipid pro®le in correlation with DHEA level and body weight and body composition in type 2 diabetic men. DESIGN: Longitudinal, controlled clinical intervention study with exercise training consisting of an 8 week supervised program of aerobic exercise (75% VO 2 peak, 45 min), twice a week and intermittent exercise, once a week, on a bicyle ergometer. SUBJECTS: Sixteen men (age 45.4 AE 7.2 y (mean AE s.d.), HbA1c 8.15 AE 1.7%, body mass index (BMI) 29.6 AE 4.6 kgam 2 ) were randomly divided into two groups: trained group (n 8) and control group (n 8 P`0.001), and DHEA levels (11.00 AE 3.10 vs 14.25 AE 4.10 nmolal, P`0.05) with no modi®cation in body weight. Changes in triglycerides were negatively correlated with changes in DHEA (r À0.81, P 0.03). This correlation was independent of changes in abdominal fat distribution. CONCLUSION: Training decreases abdominal fat depots, improves muscular mass and affects favourably triglyceride and DHEA levels. Changes in triglycerides and DHEA were inversely related.

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Section: Discussionmentioning

confidence: 99%

“…4,5 Indeed, type 2 diabetic patients with serum triglycerides above 2.3 mmolal have a 2-fold increased risk of CHD. 4 Elevation of triglyceride levels in type 2 diabetes results mainly from an overproduction of VLDL triglyceride. 29 Prospective studies have suggested that low levels of DHEAS and DHEA predict the occurence of CHD in men.…”

Section: Discussionmentioning

confidence: 99%

Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes

et al. 2001

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“…O encontro de um efeito independente para as variáveis hábito de fumar, história de hipercolesterolemia e história de hipertensão arterial estão em consonância com os resultados apontados na literatura, sendo considerados os mais importantes fatores de risco para a DIC 4,9,14 . Tais achados implicam no reconhecimento de um contexto multifatorial para a DIC, recomendando a implementação de Ações de Saúde direcionadas para a prevenção e controle simultâneos de tais fatores de risco.…”

Section: Discussionunclassified

Diabetes mellitus e doença isquêmica do coração: estudo tipo caso-controle

Moraes

Souza

1996

Rev. Saúde Pública

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ResumoObjetivou-se testar a associação do diabetes mellitus com a doença isquêmica do coração, procedendo-se ao ajustamento simultâneo para possíveis variáveis de confusão e/ou modificadoras de efeito. O estudo foi planejado sob a forma de um desenho tipo caso-controle, a coleta de dados estendeu-se de março de 1993 a fevereiro de 1994. Utilizou-se a estratégia de compor três bancos de dados que permitiram a realização do estudo em duas bases populacionais: uma base primária e uma base secundária. A amostra total foi composta por 833 indivíduos de ambos os sexos, na faixa etária de 30 a 69 anos completos, sendo todos residentes no município de São Paulo. A técnica estatística utilizada para a análise dos dados foi a regressão logística multivariada. Os resultados permitiram identificar que o diabetes mellitus não se constituiu em fator de risco independente para a doença isquêmica do coração, nas duas bases populacionais estudadas. Por outro lado, foi possível identificar, de forma consistente, um efeito independente para as variáveis hipertensão arterial, hipercolesterolemia, hábito de fumar e antecedentes familiares de cardiopatia. As interações consideradas de interesse, combinando-se história positiva de diabetes com as categorias de exposição de outras variáveis, não apresentaram significância estatística. São apresentadas algumas razões de ordem metodológica que exerceriam influência sobre a magnitude das medidas de efeito em diferentes bases populacionais. Conclui-se que o desaparecimento da associação diabetes x doença isquêmica do coração foi decorrente da presença, nos modelos, de potentes fatores de risco. Diabetes mellitus, complicações. Isquemia miocárdia. Estudos de casos e controles. AbstractSeveral works have been reported diabetes as an independent risk factor for ischaemic heart disease. The use of different methodologies have been an obstacle to a comparison of these studies. The study realized has sought to test the association between diabetes and ischaemic heart disease, after adjusting for known confounders and/or modifiers of effect. The study was designed as a case control study and the period of data collection was one year (March/93 to February/94

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“…14 It is currently unknown, however, whether these defects are inherent features of type 2 diabetes or secondary to metabolic alterations such as chronic hyperglycemia, 15,16 increases in free fatty acid (FFA) concentrations, [17][18][19][20][21] or other lipid abnormalities. 18,22,23 Regarding insulin, acute studies have shown that although physiological changes in circulating insulin concentrations do not alter blood flow, they potentiate ACh-induced vasodilatation. 24 The only treatment study hitherto performed in type 2 diabetes examined effects of antioxidants on endothelial function.…”

mentioning

confidence: 99%

Insulin Therapy Improves Endothelial Function in Type 2 Diabetes

Vehkavaara¹,

Mäkimattila²,

Schlenzka³

et al. 2000

ATVB

108

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Abstract-A total of 75 in vivo endothelial function tests (intrabrachial artery infusions of endothelium-dependent[acetylcholine] and -independent [sodium nitroprusside] vasoactive agents) were performed in 18 type 2 diabetic patients (aged 58Ϯ2 years, body mass index 28.5Ϯ0.6 kg/m 2 , and fasting plasma glucose 229Ϯ11 mg/dL) and 27 matched normal subjects. These tests were performed before and 6 months after combination therapy with insulin and metformin and before and 6 months after metformin therapy only. Before insulin therapy, blood flow responses to acetylcholine (15 g/min) were significantly blunted in type 2 diabetic patients (7.5Ϯ0.7 mL ⅐ dL Ϫ1 ⅐ min Ϫ1) compared with normal subjects (11.6Ϯ0.9 mL ⅐ dL Ϫ1 ⅐ min Ϫ1 , PϽ0.01). During insulin therapy, the acetylcholine response increased by 44% to 10.8Ϯ1.6 mL ⅐ dL Ϫ1 ⅐ min Ϫ1 (PϽ0.05). Insulin therapy also significantly increased the blood flow responses to both low and high doses of sodium nitroprusside. We conclude that insulin therapy improves endothelium-dependent and -independent vasodilatation. These data support the idea that insulin therapy has beneficial rather than harmful effects on vascular function.

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Lipids and lipoproteins predicting coronary heart disease mortality and morbidity in patients with non-insulin-dependent diabetes.

Abstract: Our 7-year follow-up study gives evidence that low HDL and HDL2 cholesterol, high VLDL cholesterol, and high total and VLDL triglycerides are powerful risk indicators for CHD events in patients with NIDDM:

Cited by 274 publications

References 52 publications

Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes

Exercise training-induced triglyceride lowering negatively correlates with DHEA levels in men with type 2 diabetes

Diabetes mellitus e doença isquêmica do coração: estudo tipo caso-controle

Insulin Therapy Improves Endothelial Function in Type 2 Diabetes

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