Lipids and All-Cause Mortality among Older Adults: A 12-Year Follow-Up Study

Abstract

This is a 12-year follow-up cohort study with 800 people (60–85 years old). The association between lipid disorders and mortality was analysed by Cox proportional hazard adjusted model. All-cause mortality was considered the dependent variable, and lipid disorders as independent variables: total cholesterol (TC) >200 and <170 mg/dl, HDL-c <35 and 40, LDL-c >100 and 130, and triglycerides (TG) >50. An initial analysis of all subjects was performed and a second was carried out after having excluded individuals with a body mass index (BMI) <20 kg/m2 or mortality in ≤2 years. The mortality showed a positive association with low TC and a negative association with high TC and high LDL-c. After the exclusion of underweight and premature mortality, there was a positive association only with TC <170 mg/dl (HR = 1.36, CI95%: 1.02–1.82). The data did not show a higher risk with high levels of TC, LDL-c, and TG. However, they showed higher mortality among older adults with low TC.

Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: Data from the Chinese Longitudinal Healthy Longevity Survey

“…Compared with participants who had a lower LDL-C, those with high concentrations had a 40% lower mortality risk, which was consistent with several other studies [9–14, 21]. A follow-up study in France reported that lower level of LDL-C was associated with increased mortality risk for hospitalized elderly patients [11].…”

“…Studies further demonstrated that higher LDL-C was associated with reduced risk of mortality for both Japanese very elderly [13] and oldest old [23]. This phenomenon was also found in an elderly Brazilian cohort [9], elderly Italian women [14], non-demented elderly [11] and elderly patients with heart failure [12] in the United States.…”

“…Some studies showed that high concentrations of LDL-C were associated with higher risk of mortality and morbidity of cardiovascular and cerebrovascular diseases or all-cause mortality among the elderly [2, 3], while other studies found that low LDL-C concentrations were associated with increased mortality risk from non-cardiovascular disease [4], such as cancer [5], infection [6], liver diseases [7], and trauma [8] among elderly. Several studies also concluded that LDL-C was inversely associated with the risk of death in elderly people [9–14], which has attracted particular attention regarding the necessity for LDL-C lowering therapy in the aged population.…”

An epigenetic predictor of death captures multi-modal measures of brain health

“…For cross-sectional analyses, we did not wish to determine whether Wave 1 (age: 70 years) epigenetic data associated with Wave 2 (age: 73 years) phenotypic data in order to limit the potential issue of retrocausality. In this first section, we also investigated the cross-sectional association of an accelerated DNAm GrimAge with a number of physical (body mass index, height, grip strength, lung function and weight) and blood traits (albumin, C-reactive protein, cholesterol, creatinine, ferritin, interleukin-6 and iron; at Wave 2; age 73 years) that have been related to mortality and frailty in older age [34][35][36][37][38][39][40][41][42].…”

Lipid Blood Profile in Old Patients With Ischemic Heart Disease

“…Большинство подобных исследований было проведено с участием лиц среднего или пожилого возраста. Однако роль дислипидемии при различных заболеваниях в старческом возрасте не столь однозначна [2,4,5]. В последнее время накапливается все больше подтверждений того, что по мере старения негативный эффект ХС в отношении сердечно-сосудистой заболеваемости и смертности уменьшается [5].…”