Lipids and Adipokines in Cord Blood and at 72 h in Discordant Dichorionic Twins

Milenković, S.; Janković, Bojan; Mirković, Ljiljana; Jovandaric, Miljana Z.; Milenković, Dušan; Otašević, Biljana

doi:10.1080/15513815.2016.1242675

Cited by 8 publications

(6 citation statements)

References 26 publications

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“…In addition, we found that in the second and third trimesters of pregnancy, fetal weight and AC were negatively associated with cord blood TG. This finding is consistent with previous studies which found that fetuses with intrauterine growth restriction had higher cord blood TG compared with normal-growth fetus ( 29 , 30 ). Another study showed that AC was negatively associated with cord blood TG levels among growth-restricted fetuses ( 31 ).…”

Section: Discussionsupporting

confidence: 93%

Associations of Longitudinal Fetal Growth Patterns With Cardiometabolic Factors at Birth

et al. 2021

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BackgroundBirth weight is associated with cardiometabolic factors at birth. However, it is unclear when these associations occur in fetal life. We aimed to investigate the associations between fetal growth in different gestational periods and cord blood cardiometabolic factors.MethodsWe included 1,458 newborns from the Born in Guangzhou Cohort Study, China. Z-scores of fetal size parameters [weight, abdominal circumference (AC), and femur length (FL)] at 22 weeks and growth at 22–27, 28–36, and ≥37 weeks were calculated from multilevel linear spline models. Multiple linear regression was used to examine the associations between fetal growth variables and z-scores of cord blood cardiometabolic factors.ResultsFetal weight at each period was positively associated with insulin levels, with stronger association at 28–36 weeks (β, 0.31; 95% CI, 0.23 to 0.39) and ≥37 weeks (β, 0.15; 95% CI, 0.10 to 0.20) compared with earlier gestational periods. Fetal weight at 28–36 (β, −0.32; 95% CI, −0.39 to −0.24) and ≥37 weeks (β, −0.26; 95% CI, −0.31 to −0.21) was negatively associated with triglyceride levels, whereas weight at 28–36 weeks was positively associated with HDL levels (β, 0.12; 95% CI, 0.04 to 0.20). Similar results were observed for AC. Fetal FL at 22 and 22–27 weeks was associated with increased levels of insulin, glucose, and HDL.ConclusionsFetal growth at different gestational periods was associated with cardiometabolic factors at birth, suggesting that an interplay between fetal growth and cardiometabolic factors might exist early in pregnancy.

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Section: Discussionsupporting

confidence: 93%

Associations of Longitudinal Fetal Growth Patterns With Cardiometabolic Factors at Birth

et al. 2021

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“…Statistical analyses were performed using Statistica version 13.1 (Statsoft, Poland). The sample size of 32 pair of twins (64 patients) has been shown to have a statistically significant impact on the assessment of insulin resistance and endocrine disorders both for the twin and singleton gestation population studies 23,24 . The distribution of the analyzed data was checked by Shapiro-Wilk test.…”

Section: Statistical Data Analysismentioning

confidence: 99%

C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins—possible link to metabolic programming?

et al. 2020

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Children born small for gestational age (SGA) are at increased risk of future glucose intolerance and type 2 diabetes, possibly after due intrauterine metabolic programming. Soluble leptin receptor (SLR) limits leptin access to signaltransducing membrane receptors. The present study examines whether SGA and appropriate for gestational age (AGA) twins differ with regard to their C-peptide, glucose and leptin systems. The markers C-peptide, glucose, fetal leptin, and SLR in cord blood were assessed in children from dichorionic twin pregnancies at delivery. In 32 cases, weight differed by >15% between twins: one demonstrated Intrauterine Growth Retardation (IUGR) (<10th percentile-SGA), while the other did not (AGA I). The other 67 pairs presented appropriate weight for gestational age (AGA II). Placental leptin and placental leptin receptor content were also assessed. Despite the same concentrations of glucose, the SGA twins maintained a higher level of C-peptide [44.48 pmol/l vs. 20.91 pmol/l, p < 0.05] than the AGA I co-twins, higher HOMA index, calculated as [C-peptide] x [Glucose] (p = 0.045), in cord blood, and a higher level of SLR [SGA vs AGA I-mean: 28.63 ng/ml vs. 19.91 ng/ml, p < 0.01], without any differences in total leptin (p = 0.37). However, SGA placentas demonstrated higher leptin level [130.1 pg/100 g total protein vs 83.8 pg/100 g total protein, p = 0.03], without differences in placental leptin receptor (p = 0.66). SGA/IUGR twins demonstrate relative insulin resistance accompanied by decreased fetal and increased placental leptin signaling. We speculate that relative insulin resistance and changes in the leptin system might be the first evidence of processes promoting deleterious metabolic programming for post-natal life.

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“…Simultaneously, it was suggested that placental insufficiency is associated with an increase in placental leptin production . Furthermore, some studies demonstrated that leptin levels are lower in IUGR, but differences were not significant , and it was also reported that cord blood leptin levels did not differ significantly in IUGR compared to normal pregnancies . These data suggest that the association between leptin and IUGR is controversial.…”

Section: Leptin and Pathologies Associated With Pregnancymentioning

confidence: 99%

Leptin action in normal and pathological pregnancies

Pérez-Pérez

Toro

Vilariño-García

et al. 2017

J Cellular Molecular Medi

157

159

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Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto‐placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin‐producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre‐eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.

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Lipids and Adipokines in Cord Blood and at 72 h in Discordant Dichorionic Twins

Abstract: IUGR is related to lower leptin level and proatherogenic lipid profile (higher TG and lower HDL-C), which are not influenced by adipokine at birth.

Cited by 8 publications

References 26 publications

Associations of Longitudinal Fetal Growth Patterns With Cardiometabolic Factors at Birth

Associations of Longitudinal Fetal Growth Patterns With Cardiometabolic Factors at Birth

C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins—possible link to metabolic programming?

Leptin action in normal and pathological pregnancies

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