Lipids: An insight into the neurodegenerative disorders

Shamim, Arshiya; Mahmood, Tarique; Ahsan, Farogh; Kumar, Arun; Bagga, Paramdeep

doi:10.1016/j.yclnex.2018.05.001

Cited by 102 publications

(69 citation statements)

References 120 publications

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“…These results are consistent with recent studies suggesting that gut microbiome can influence lipid metabolism in various systems (Matey-Hernandez et al, 2018). Moreover, lipid metabolism may play a role in both protection and deterioration of neurons in various neurodegenerative disorders (Dupuis et al, 2008;Shamim et al, 2018).…”

Section: Fatty Acid Metabolism Genes Are Essential For Ha-114-mediatesupporting

confidence: 93%

“…Over the last few years, many studies have implicated impaired lipid metabolism in various neurodegenerative disorders, including Alzheimer's disease and ALS (Abdel-Khalik et al, 2017;Shamim et al, 2018;Wong et al, 2017). Since our data suggested that HA-114 requires the fatty acid metabolism key component kat-1 and increases acdh-1 expression, we hypothesized that the age-related neurodegeneration models we used might have disrupted lipid equilibrium and that HA-114 might restore lipid content to normal levels.…”

Section: Rhamnosus Ha-114 Restores Lipid Homeostasis In Age-relatementioning

confidence: 95%

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Probiotic Lacticaseibacillus rhamnosus HA-114 suppresses age-dependent neurodegeneration via mitochondrial beta-oxidation

Labarre

Guitard

Tossing

et al. 2020

Preprint

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The human microbiota is believed to influence health. Microbiome dysbiosis may be linked to neurological conditions like Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). We report the ability of a probiotic bacterial strain in reversing neurodegeneration phenotypes. We show that Lacticaseibacillus rhamnosus HA-114 is neuroprotective in C. elegans models of ALS and HD. Our results show that neuroprotection from L. rhamnosus HA-114 is unique from other L. rhamnosus strains, and resides in its fatty acid content. Neuroprotection by L. rhamnosus HA-114 requires acdh-1/ACADSB, kat-1/ACAT1 and elo-6/ELOVL3/6, which are key fatty acid metabolism and mitochondrial β-oxidation genes. Moreover, L. rhamnosus HA-114 delayed disease onset and suppressed motor neuron degeneration in an aggressive mouse model of ALS. Our data suggest that disrupted lipid metabolism contributes to neurodegeneration and that dietary intervention with L. rhamnosus HA-114 restores lipid homeostasis and energy balance through mitochondrial β-oxidation. L. rhamnosus HA-114 is suitable for human consumption opening the possibility of modifying disease progression by dietary intervention.

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Section: Fatty Acid Metabolism Genes Are Essential For Ha-114-mediatesupporting

confidence: 93%

Section: Rhamnosus Ha-114 Restores Lipid Homeostasis In Age-relatementioning

confidence: 95%

Probiotic Lacticaseibacillus rhamnosus HA-114 suppresses age-dependent neurodegeneration via mitochondrial beta-oxidation

Labarre

Guitard

Tossing

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…As an integral component of brain structure, fatty acids play a significant role in healthy brain function. Different diseases/disorders, e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, schizophrenia, mood disorders, are linked due to altered membrane fatty acid composition and their signalling in disease progression (Bazinet and Layé, 2014; Shamim et al, 2018). The encephalopathy “Reye syndrome” is causally associated with altered fatty acid oxidation (Orlowski, 1999).…”

Section: Dha Deficiency and Human Brain Functionmentioning

confidence: 99%

Docosahexaenoic acid, 22:6n‐3: Its roles in the structure and function of the brain

Mallick

Basak

Duttaroy

2019

Intl J of Devlp Neuroscience

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Docosahexaenoic acid,22:6n-3 (DHA) and its metabolites are vital for the structure and functional brain development of the fetus and infants, and also for maintenance of healthy brain function of adults. DHA is thought to be an essential nutrient required throughout the life cycle for the maintenance of overall brain health. The mode of actions of DHA and its derivatives at both cellular and molecular levels in the brain are emerging. DHA is the major prevalent fatty acid in the brain membrane. The brain maintains its fatty acid levels mainly via the uptake of plasma free fatty acids. Therefore, circulating plasma DHA is significantly related to cognitive abilities during ageing and is inversely associated with cognitive decline. The signaling pathways of DHA and its metabolites are involved in neurogenesis, antinociceptive effects, anti-apoptotic effect, synaptic plasticity, Ca 2+ homeostasis in brain diseases, and the functioning of nigrostriatal activities. Mechanisms of action of DHA metabolites on various processes in the brain are not yet well known. Epidemiological studies support a link between low habitual intake of DHA and a higher risk of brain disorders. A diet characterized by higher intakes of foods containing high in n-3 fatty acids, and/or lower intake of n-6 fatty acids was strongly associated with a lower Alzheimer's Disease and other brain disorders. Supplementation of DHA improves some behaviors associated with attention deficit hyperactivity disorder, bipolar disorder, schizophrenia, and impulsive behavior, as well as cognition. Nevertheless, the outcomes of trials with DHA supplementation have been controversial. Many intervention studies with DHA have shown an apparent benefit in brain function. However, clinical trials are needed for definitive conclusions. Dietary deficiency of n-3 fatty acids during fetal development in utero and the postnatal state has detrimental effects on cognitive abilities. Further research in humans is required to assess a variety of clinical outcomes, including quality of life and mental status, by supplementation of DHA.

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“…As happens with protein intake; myelination, another essential and required event in neurodevelopment is influenced by a second dietary animal product, lipids. For instance, brain lipids specify the position and role of proteins in the cell membrane and thus control synaptic neuron signals (Shamim et. al.…”

Section: One Of the Evolutionary Consequences Of This Dietary Transitmentioning

confidence: 99%

“…2018). Lipids may also act as transmitters and relay signals to intracellular compartments or other cells from the membrane (Shamim et al, 2018).…”

Section: One Of the Evolutionary Consequences Of This Dietary Transitmentioning

confidence: 99%

We think what we eat: Animal-based diet influences cerebral and microbiota networks connectivity in early ages. A study case of an indigenous community in Mexico

Ramírez-Carrillo

González‐Santoyo

López-Corona

et al. 2020

Preprint

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We are not individuals, we are much better described as ecosystems due to trillions of bacteria and other microorganisms that inhabit us. We now know that gut microbiota can greatly influence many physiological parameters that in turn may impact several cognitive functions, such as learning, memory, and decision making processes. This mutualistic symbiotic relation known as the gut-brain axis is also constrained by external factors such as dietary habits such as animal protein and lipids intake. Using a novel combination of Machine Learning and Network Theory techniques, we provide evidence from an indigenous population in Guerrero Mexico, that both brain and gut-microbiota connectivity, evaluated by Minimum Spanning Tree as the critical backbone of information flow, diminish under either low protein or lipids intake. We discuss then how this loss of connectivity may translate into a reduction of the individual’s capacity to cope with perturbations as loss of connectivity may be linked with losses in antifragility.

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Lipids: An insight into the neurodegenerative disorders

Abstract: methods, coupled with the recognition of the role of lipids in many metabolic diseases such as obesity, atherosclerosis, stroke, hypertension and diabetes.

Cited by 102 publications

References 120 publications

Probiotic Lacticaseibacillus rhamnosus HA-114 suppresses age-dependent neurodegeneration via mitochondrial beta-oxidation

Probiotic Lacticaseibacillus rhamnosus HA-114 suppresses age-dependent neurodegeneration via mitochondrial beta-oxidation

Docosahexaenoic acid, 22:6n‐3: Its roles in the structure and function of the brain

We think what we eat: Animal-based diet influences cerebral and microbiota networks connectivity in early ages. A study case of an indigenous community in Mexico

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