Lipids, adiposity and tendinopathy: is there a mechanistic link? Critical review

Scott, Alexander; Zwerver, Johannes; Grewal, Navi; de, Agnetha; Alktebi, Thuraya; Granville, David J.; Hart, David A.

doi:10.1136/bjsports-2014-093989

Cited by 77 publications

(55 citation statements)

References 51 publications

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“…Gaida et al have questioned whether the higher risk of tendinopathy associated with diabetes is caused by a disturbance in glucose metabolism per se. They proposed that the higher risk might have to be attributed to the overweight associated with diabetes [ 30 , 31 ]. The influence of overweight on tendinopathy has been explained in two different ways.…”

Section: Discussionmentioning

confidence: 99%

Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: a cross sectional study

Albers

Zwerver

Diercks

et al. 2016

BMC Musculoskelet Disord

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BackgroundLower extremity tendinopathy is a common sports injury, but it can also affect non-athletes. Because tendinopathy is difficult to treat and has negative effects on the ability to work and quality of life, development of preventive interventions is important. The first step in the Van Mechelen prevention model is to determine the extent of the problem. The primary aim of this study was to determine the incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population. The secondary aim was to investigate possible associated factors.MethodsA cross-sectional study was performed in a Dutch general practice. Using International Classification of Primary Care codes, the electronic patient files were searched to identify cases of adductor tendinopathy, greater trochanteric pain syndrome, jumper’s knee, Achilles tendinopathy, and plantar fasciopathy in 2012. The tendinopathy patients were compared to the general practice population regarding age, gender, use of medication, and comorbidity using 95 % confidence intervals.ResultsThe prevalence and incidence rates of lower extremity tendinopathy found in this study were 11.83 and 10.52 per 1000 person-years. Lower extremity tendinopathy was more prevalent among older patients. No differences between tendinopathy patients and the general practice population were found regarding gender, use of medication, or comorbidity.ConclusionsIn this cross-sectional study in a Dutch general practice, the prevalence and incidence rates of lower extremity tendinopathy were 11.83 and 10.52 per 1000 person-years. Lower extremity tendinopathy deserves a higher place in locomotor system research to develop preventive interventions.

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Section: Discussionmentioning

confidence: 99%

Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: a cross sectional study

Albers

Zwerver

Diercks

et al. 2016

BMC Musculoskelet Disord

Self Cite

215

152

View full text Add to dashboard Cite

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“…Moreover, the average BMI of people with diabetes is as high as 30 kg/m 2 (ie, obese),61 suggesting high baseline levels of adiposity in people with diabetes. There is evidence for an association between tendinopathy and adiposity so this may be another important possible confounder 5 65 66…”

Section: Discussionmentioning

confidence: 99%

Is there an association between tendinopathy and diabetes mellitus? A systematic review with meta-analysis

et al. 2015

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“…Epidemiologic studies have identified an association between waist circumference and tendon pathology, 25 with preliminary evidence supporting either a mechanical effect (due to increased load) or systemic effect (due to circulating lipids). 26 The influence of adiposity on localized musculo-tendinous tissues in neuromuscular disorders will be an important factor to evaluate with the increasing rates of obesity in society.…”

Section: Resultsmentioning

confidence: 99%

Normative reference values for strength and flexibility of 1,000 children and adults

et al. 2017

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Objective: To establish reference values for isometric strength of 12 muscle groups and flexibility of 13 joint movements in 1,000 children and adults and investigate the influence of demographic and anthropometric factors.Methods: A standardized reliable protocol of hand-held and fixed dynamometry for isometric strength of ankle, knee, hip, elbow, and shoulder musculature as well as goniometry for flexibility of the ankle, knee, hip, elbow, shoulder, and cervical spine was performed in an observational study investigating 1,000 healthy male and female participants aged 3-101 years. Correlation and multiple regression analyses were performed to identify factors independently associated with strength and flexibility of children, adolescents, adults, and older adults. Results:Normative reference values of 25 strength and flexibility measures were generated.Strong linear correlations between age and strength were identified in the first 2 decades of life. Muscle strength significantly decreased with age in older adults. Regression modeling identified increasing height as the most significant predictor of strength in children, higher body mass in adolescents, and male sex in adults and older adults. Joint flexibility gradually decreased with age, with little sex difference. Waist circumference was a significant predictor of variability in joint flexibility in adolescents, adults, and older adults. Conclusions:Reference values and associated age-and sex-stratified z scores generated from this study can be used to determine the presence and extent of impairments associated with neuromuscular and other neurologic disorders, monitor disease progression over time in natural history studies, and evaluate the effect of new treatments in clinical trials. Neurology ® 2017;88:36-43Meaningful, reliable, and sensitive outcome measures are required to monitor treatment and progression of neuromuscular and other neurologic disorders. While there have been substantial advances in the understanding of the pathogenesis and natural history of many neuromuscular disorders, the identification and development of new outcome measures that best reflect the efficacy of specific treatments have not advanced at the same rate. 1 Establishing valid and responsive outcome measures is a priority for the field. 2 To assist in the development of new outcome measures, normative reference values generated from large populations across the lifespan using standardized methods are required. Normative reference values can be utilized to generate z scores, which can be used in multicenter studies to improve outcome measure precision and responsiveness.Muscle weakness and joint contractures predispose to numerous pathologies requiring intervention. Reference data play an important role in identifying and quantifying these impairments and evaluating the effectiveness of interventions. Currently, few comprehensive datasets detail the normal variation of active range of motion in healthy individuals and are limited by the number of joints assessed, 3...

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Lipids, adiposity and tendinopathy: is there a mechanistic link? Critical review

Cited by 77 publications

References 51 publications

Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: a cross sectional study

Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: a cross sectional study

Is there an association between tendinopathy and diabetes mellitus? A systematic review with meta-analysis

Normative reference values for strength and flexibility of 1,000 children and adults

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