Lipidomics reveal the cognitive improvement effects of <i>Acer truncatum Bunge</i> seed oil on hypoxic–ischemic encephalopathy rats

Chen, Xianyang; Song, Wangting; Song, Yao‐Hua; Cao, Hongli; Xu, Xin; Li, Shujia; Fu, Yongjian; Xue, Teng; Ding, Chunguang; Lin, Feng; Shi, Yuan; Li, Jiujun

doi:10.1039/d3fo01583a

Cited by 4 publications

(4 citation statements)

References 52 publications

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“…1a ), which has been reported in the literature as a possible cause of impaired lateral branch circulation 61 , 62 . In addition, in our previous study, we reported the results of HE staining and metabolic analysis in sham surgery rats, which also confirm the success of HIE model 63 . Due to the limited availability of samples, we are unable to perform comprehensive validation procedures for numerous biomarkers, including genes expression and lipids calculation, after transcriptomic and lipidomic assays.…”

Section: Discussionsupporting

confidence: 78%

“…In addition, we collected separately all remaining rat brain tissue from each of the two groups for histological evaluation ( n = 6), lipidomics ( n = 8), and transcriptomic studies ( n = 13). Especially, before the ASO intervention, we conducted a detailed examination and comparison of the Sham group ( n = 8) and the Model group ( n = 8), which was consistent with our previous study 63 . All samples were stored at −80 °C before use.…”

Section: Methodssupporting

confidence: 67%

“…Based on the recommended daily intake of NA is 0.3 g/day, ASO and vehicle (corn oil) were administered to rats at 30 mg/kg by gavage, according to the equivalent dose calculated on the body weight of humans and animals. ASO was extracted from Acer truncatum Bunge seed extract by supercritical 65 and provided by Baofeng Biotechnology (Beijing) Co., Ltd., and the component test report was issued 63 .…”

Section: Methodsmentioning

confidence: 99%

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Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude

Chen,

Song,

Song

et al. 2023

Commun Biol

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Hypoxic-ischemic encephalopathy (HIE) at high-altitudes leads to neonatal mortality and long-term neurological complications without effective treatment. Acer truncatum Bunge Seed extract (ASO) is reported to have effect on cognitive improvement, but its molecular mechanisms on HIE are unclear. In this study, ASO administration contributed to reduced neuronal cell edema and improved motor ability in HIE rats at a simulated 4500-meter altitude. Transcriptomics and WGCNA analysis showed genes associated with lipid biosynthesis, redox homeostasis, neuronal growth, and synaptic plasticity regulated in the ASO group. Targeted and untargeted-lipidomics revealed decreased free fatty acids and increased phospholipids with favorable ω-3/ω-6/ω-9 fatty acid ratios, as well as reduced oxidized glycerophospholipids (OxGPs) in the ASO group. Combining multi-omics analysis demonstrated FA to FA-CoA, phospholipids metabolism, and lipid peroxidation were regulated by ASO treatment. Our results illuminated preliminary metabolism mechanism of ASO ingesting in rats, implying ASO administration as potential intervention strategy for HIE under high-altitude.

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Section: Discussionsupporting

confidence: 78%

Section: Methodssupporting

confidence: 67%

Section: Methodsmentioning

confidence: 99%

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Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude

Chen,

Song,

Song

et al. 2023

Commun Biol

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“…9 ATSO has been demonstrated to prevent and ameliorate various neurological diseases such as experimental allergic encephalomyelitis, Parkinson's disease, cognitive impairment, adrenoleukodystrophy and hypoxic-ischemic encephalopathy. 10–17 Improvement of mitochondrial function and promotion of myelin regeneration are considered to be the main mechanisms of ATSO in ameliorating neurological diseases. Although these findings suggested that ATSO may also be beneficial for chemotherapy-induced demyelination, important questions regarding its cytological basis and molecular mechanisms remain to be answered.…”

Section: Introductionmentioning

confidence: 99%

Acer truncatum Bunge seed oil ameliorated oxaliplatin-induced demyelination by improving mitochondrial dysfunction via the Pink1/Parkin mitophagy pathway

Cheng,

Wang,

Guo

et al. 2024

Food Funct.

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Changes of fatty acid metabolism in FA 26:0, FA 22:2 and FA 24:1 are associated with leukoaraiosis in the elderly

Song,

Lin,

Cao

et al. 2024

Preprint

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Background: Cerebrovascular diseases in the elderly are associated with abnormal lipids metabolism. Although cerebral small vascular disease like Leukoaraiosis (LA) is reported to be common among the elderly with occurrence and progression of neurological disease, there are no effective treatments and even biomarkers screening for LA due to the limited understanding of its biochemical processes. Here, we employ untargeted and targeted lipidomic strategies to provide insights into LA onset associated with lipid disturbance. Results: A total of 122 participants were recruited, following exclusion criteria and propensity score matching, the final cohort consisted of 16 LA patients and 18 control subjects (CK). Untargeted lipid profiling identified 50 significantly different metabolites between LA and CK groups. Pathway enrichment and structural equation modeling demonstrated that fatty acid (FA) metabolism had significant impacts on LA onset. Compared with CK group, targeted free fatty acid (FFA) profiling revealed a significant decrease of FA C22:2 as well as FA 24:1 and increase of FA 26:0 in LA group, which were proved as potential biomarkers by logistic regression and decision curve models. WGCNA coupling with correlation analysis unveiled FA 26:0 mainly came out of ceramide (18:1/26:0), and FA 24:1 was initiated from phosphatidylcholine hub-transformed by lysophosphatidic acid (20:5), and FA 22:2 was mainly generated through glycerolipid. Conclusion: Our results demonstrated potential FFA biomarkers for LA screening, and illuminated preliminary metabolism process from lipid disturbance to FFAs alternation in LA patients, implying regulation of FA 26:0, FA 22:2 and FA 24:1 constituting in-depth mechanism for further studies of LA.

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Lipidomics reveal the cognitive improvement effects of Acer truncatum Bunge seed oil on hypoxic–ischemic encephalopathy rats

Abstract: Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of acute neonatal death and chronic neurological damage, and severe HIE can have secondary sequelae such as cognitive impairment and cerebral...

Cited by 4 publications

References 52 publications

Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude

Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude

Acer truncatum Bunge seed oil ameliorated oxaliplatin-induced demyelination by improving mitochondrial dysfunction via the Pink1/Parkin mitophagy pathway

Changes of fatty acid metabolism in FA 26:0, FA 22:2 and FA 24:1 are associated with leukoaraiosis in the elderly

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