Lipidomics: Novel insight into the biochemical mechanism of lipid metabolism and dysregulation-associated disease

Zhao, Ying-Yong; Miao, Hua; Cheng, Xian‐Long; Wei, Feng

doi:10.1016/j.cbi.2015.09.005

Cited by 104 publications

(74 citation statements)

References 178 publications

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“…Lipidomics is a branch of metabolomics, with a focus on the analysis of lipid components including fatty acids, glycerolipids, glycerophospholipids, sphingolipids, prenol lipids, saccharolipids, and polyketides [25,26,82]. Lipids are essential for biological processes, are important components of signaling pathways, and are closely linked to disease processes.…”

Section: Metabolomics and Immunometabolism Relationshipsmentioning

confidence: 99%

Potential Impact of Nutrition on Immune System Recovery from Heavy Exertion: A Metabolomics Perspective

Nieman

Mitmesser²

2017

Nutrients

105

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This review describes effective and ineffective immunonutrition support strategies for the athlete, with a focus on the benefits of carbohydrates and polyphenols as determined from metabolomics-based procedures. Athletes experience regular cycles of physiological stress accompanied by transient inflammation, oxidative stress, and immune perturbations, and there are increasing data indicating that these are sensitive to nutritional influences. The most effective nutritional countermeasures, especially when considered from a metabolomics perspective, include acute and chronic increases in dietary carbohydrate and polyphenols. Carbohydrate supplementation reduces post-exercise stress hormone levels, inflammation, and fatty acid mobilization and oxidation. Ingestion of fruits high in carbohydrates, polyphenols, and metabolites effectively supports performance, with added benefits including enhancement of oxidative and anti-viral capacity through fruit metabolites, and increased plasma levels of gut-derived phenolics. Metabolomics and lipidomics data indicate that intensive and prolonged exercise is associated with extensive lipid mobilization and oxidation, including many components of the linoleic acid conversion pathway and related oxidized derivatives called oxylipins. Many of the oxylipins are elevated with increased adiposity, and although low in resting athletes, rise to high levels during recovery. Future targeted lipidomics-based studies will help discover whether n-3-polyunsaturated fatty acid (n-3-PUFA) supplementation enhances inflammation resolution in athletes post-exercise.

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Section: Metabolomics and Immunometabolism Relationshipsmentioning

confidence: 99%

Potential Impact of Nutrition on Immune System Recovery from Heavy Exertion: A Metabolomics Perspective

Nieman

Mitmesser²

2017

Nutrients

105

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“…The HPLC–ESI/MS strategy can enhance sensitivity and accuracy for low abundance lipids and was generally applied to targeted and un-targeted lipidomics. Recently, thanks to the development of ultra-high performance liquid chromatography (UHPLC), the resolution is greatly increased, in turn reducing ion suppression [9]. …”

Section: Analytical Technology In Lipidomicsmentioning

confidence: 99%

“…Therefore, bioactive lipids play an important role in many biological process, in particular their composition is altered in many neoplastic diseases [8]. Several previous research groups have investigated lipid alterations in cancer cells to elucidate the disease and discover potential biomarkers [9]. For example, eicosanoids play a role in neoplastic transformation of cancer cells, generated effects in proliferation, motility, migration, invasion, apoptosis, metastasis and angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, this approach allows the evaluation of anticancer treatment, in terms of responsivity or resistance, and can be applied to the discovery of new tumor biomarkers [9]. Integration of lipidomic strategies in cancer research could generate new opportunities to obtain insights into diagnosis, prognosis and prediction of tailored therapies [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Advances in Lipidomics for Cancer Biomarkers Discovery

Perrotti

Rosa

Cicalini

et al. 2016

IJMS

160

119

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Lipids play critical functions in cellular survival, proliferation, interaction and death, since they are involved in chemical-energy storage, cellular signaling, cell membranes, and cell–cell interactions. These cellular processes are strongly related to carcinogenesis pathways, particularly to transformation, progression, and metastasis, suggesting the bioactive lipids are mediators of a number of oncogenic processes. The current review gives a synopsis of a lipidomic approach in tumor characterization; we provide an overview on potential lipid biomarkers in the oncology field and on the principal lipidomic methodologies applied. The novel lipidomic biomarkers are reviewed in an effort to underline their role in diagnosis, in prognostic characterization and in prediction of therapeutic outcomes. A lipidomic investigation through mass spectrometry highlights new insights on molecular mechanisms underlying cancer disease. This new understanding will promote clinical applications in drug discovery and personalized therapy.

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“…Lipidomics has been used for the diagnosis and therapy of several diseases, as it involves the study of the dynamic adaptation of lipids to harsh conditions and the metabolic pathways of lipids [30,32]. The qualitative and quantitative analysis of the lipidome of a cell enables the use of a more accurate composition of model systems in both experimental and simulation studies.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Shedding light on the puzzle of drug-membrane interactions: Experimental techniques and molecular dynamics simulations

Lopes

Jakobtorweihen

Nunes

et al. 2017

Progress in Lipid Research

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Lipidomics: Novel insight into the biochemical mechanism of lipid metabolism and dysregulation-associated disease

Cited by 104 publications

References 178 publications

Potential Impact of Nutrition on Immune System Recovery from Heavy Exertion: A Metabolomics Perspective

Potential Impact of Nutrition on Immune System Recovery from Heavy Exertion: A Metabolomics Perspective

Advances in Lipidomics for Cancer Biomarkers Discovery

Shedding light on the puzzle of drug-membrane interactions: Experimental techniques and molecular dynamics simulations

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