Lipidomics as a Tool in the Diagnosis and Clinical Therapy

Abstract

The lipids are essential compounds of cells, with biochemical and structural properties. Lipids are classified according to their chain length or saturation levels and biogenesis. Lipidomics is a spectroscopic and spectrometric technique, like Mass Spectrometry and Nuclear Magnetic Resonance, as well as bioinformatics to quantify and characterize the lipid profile. Lipidomics enables the fundamental understanding of lipid biology, the identification of drug targets for therapy, and the discovery of lipid biomarkers of disease cohorts. Therefore, lipidomics allows knowing the diagnosis and clinical follow-up in medical therapy towards any disease. In this way, the lipid profile allows us to monitor the administration of a clinical treatment and assertively diagnose human diseases.

Implementation of Modern Therapeutic Drug Monitoring and Lipidomics Approaches in Clinical Practice: A Case Study with Colistin Treatment

“…Lipidomics, as a part of systems biology, aids in understanding lipid metabolism, identifying biomarkers, and discovering therapeutic targets for lipid-related diseases [ 56 , 57 ], which was documented, e.g., in the case of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, cancer, or inflammation or in antiviral therapies [ 58 ]. Moreover, lipid profile helps to monitor the administration of clinical treatment and diagnose human diseases [ 59 ]. Recently, lipid changes have often been evaluated in septic patients [ 60 , 61 , 62 , 63 ].…”