Lipidomics analysis reveals new insights into the goose fatty liver formation

Wei, Rongxue; Ning, Rong; Han, Chunchun; Wei, Shuhong; Teng, Yongqiang; Li, Liang; Liu, Hehe; Hu, Shengqiang; Kang, Bo; Xu, Hengyong

doi:10.1016/j.psj.2022.102428

Cited by 6 publications

(6 citation statements)

References 37 publications

(40 reference statements)

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“…This goose fatty liver induced by HFD is similar to the pathogenesis of NAFLD [ 2 , 45 , 46 ]. Animal models of NAFLD are predominantly established using high-fat dietary feeding, pharmacological intervention, and genetic modification.…”

Section: Discussionmentioning

confidence: 96%

“…Animal models of NAFLD are predominantly established using high-fat dietary feeding, pharmacological intervention, and genetic modification. These models encompass a diverse range of mammals, spanning monkeys [ 47 ], mice [ 48 ], rats [ 49 ], pigs [ 50 ], rabbits [ 51 ], and geese [ 46 ], with each model offering distinct advantages and holding specific applicability. The goose HFD liver is significantly yellow compared to the dark red liver of the normal-diet group, and lipid droplet deposition has previously been reported in goose livers [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…The unique lipid metabolism mechanism in geese, enabling efficient fat accumulation in the liver and positioning them as an ideal model for studying non-alcoholic fatty liver disease (NAFLD), not only enhances our understanding of lipid metabolism but also reveals protective responses to overfeeding, offering novel strategies for increasing goose fatty liver production and preventing fatty liver disease in other species [ 5 , 6 ]. Moreover, the physiological capability of significant post-overfeeding enlargement in goose fatty liver without evident pathological symptoms indicates the presence of protective mechanisms, making it a distinct model for fatty liver research and promising innovative approaches to enhance goose fatty liver production and avert fatty liver disease across various species [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

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Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet

Gao,

Liu,

et al. 2024

J Animal Sci Biotechnol

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Background Goose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant energy intake. As a result, goose offers an excellent model for studying obesity, metabolic disorders, and liver diseases in mammals. Although the impact of the three-dimensional arrangement of chromatin within the cell nucleus on gene expression and transcriptional regulation is widely acknowledged, the precise functions of chromatin architecture reorganization during fat deposition in goose liver tissues still need to be fully comprehended. Results In this study, geese exhibited more pronounced changes in the liver index and triglyceride (TG) content following the consumption of the high-fat diet (HFD) than mice without significant signs of inflammation. Additionally, we performed comprehensive analyses on 10 goose liver tissues (5 HFD, 5 normal), including generating high-resolution maps of chromatin architecture, conducting whole-genome gene expression profiling, and identifying H3K27ac peaks in the livers of geese and mice subjected to the HFD. Our results unveiled a multiscale restructuring of chromatin architecture, encompassing Compartment A/B, topologically associated domains, and interactions between promoters and enhancers. The dynamism of the three-dimensional genome architecture, prompted by the HFD, assumed a pivotal role in the transcriptional regulation of crucial genes. Furthermore, we identified genes that regulate chromatin conformation changes, contributing to the metabolic adaptation process of lipid deposition and hepatic fat changes in geese in response to excessive energy intake. Moreover, we conducted a cross-species analysis comparing geese and mice exposed to the HFD, revealing unique characteristics specific to the goose liver compared to a mouse. These chromatin conformation changes help elucidate the observed characteristics of fat deposition and hepatic fat regulation in geese under conditions of excessive energy intake. Conclusions We examined the dynamic modifications in three-dimensional chromatin architecture and gene expression induced by an HFD in goose liver tissues. We conducted a cross-species analysis comparing that of mice. Our results contribute significant insights into the chromatin architecture of goose liver tissues, offering a novel perspective for investigating mammal liver diseases.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet

Gao,

Liu,

et al. 2024

J Animal Sci Biotechnol

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“…Studies have shown that changes in PC and/or PE content in various tissues are associated with metabolic disorders such as atherosclerosis, insulin resistance and obesity. 27 , 34 …”

Section: Discussionmentioning

confidence: 99%

Lipidomics Analysis Deepen Understanding the Molecular Mechanisms in a Gouty Model Induced by Combination of MSU Crystals Injection and High-Fat Diet Feeding and the Intervention Mechanisms of Allopurinol

Li,

Shi,

et al. 2024

JIR

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Background Gouty arthritis (GA) is a common inflammatory disease caused by deposition of monosodium urate (MSU) crystals in diarthrodial joints. GA attacks commonly involved in joint with red, swollen, heat and pain, and often happened in unilateral foot-first metatarsophalangeal. Accumulated studies have proved that lipids play critical roles in biological processes and lipids biomarkers can substitute for the diagnosis of various diseases. Methods Herein, shotgun lipidomics was used to quantitatively analyze serum lipidomes of a gouty model which was induced by injecting MSU crystals and feeding high-fat diet with/without treatment with allopurinol. Meanwhile, ELISA kit was used to detect mouse serum levels of inflammatory cytokines (eg, tumor necrosis factor-α, interleukin 1 beta) and HE staining was used to observe the infiltration of inflammatory cells in the foot pad. Results A total of 9 types of serum lipids were detected in lipidomics by shotguns, and the result of NMDS’ analysis demonstrated significant differences in lipids profiles between the control and model group. It is worth noting that lipid abnormality in GA (such as Ceramide (Cer), sphingomyelin (SM), 4-hydroxyalkenals (HNE), phosphatidylinositol (PI), ethanolamine glycerophospholipid (PE), etc.) is related with phospholipid and energy metabolism, and allopurinol treatment could correct the aberrant metabolism of lipid to some extent. Conclusion Our results indicated that various aberrant lipid metabolisms were present in the established gouty model, and allopurinol treatment could relief this aberrant metabolism of lipids to some degree.

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“…Goose fatty liver disease, which is associated with decreased inflammation and immune reactions, has shown potential for recovery, making it a valuable model for studying fatty liver in humans and other animals [ 9 ]. While there is an initial understanding of the molecular mechanisms underlying goose fatty liver disease [ 10 ], most liver functions are not fully mature during the embryonic and neonatal stages. As individuals grow, the liver undergoes numerous changes, leading to variations in liver function throughout development [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of circRNA–miRNA–mRNA Interactions in the Regulation of Goose Liver Development

Liu,

Li,

et al. 2024

Animals

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The liver, a crucial metabolic organ in animals, is responsible for the synthesis, breakdown, and transport of lipids. However, the regulatory mechanisms involving both coding and noncoding RNAs that oversee the development of the goose liver remain elusive. This study aimed to fill this knowledge gap by conducting RNA-seq to profile the expression of circular RNAs (circRNAs) and microRNAs (miRNAs) during goose liver development. We analyzed circRNAs in liver samples from Sichuan white geese at three developmental stages: posthatching day 0, 10 weeks (fast growth stage), and 30 weeks (sexual maturation stage). Our findings revealed 11,079 circRNAs and 994 miRNAs, among which the differentially expressed circRNAs and miRNAs were significantly enriched in pathways such as fatty acid biosynthesis, degradation, and metabolism. Further analysis of the target genes of the differentially expressed miRNAs revealed enrichment in pathways related to fatty acid biosynthesis, metabolism, PPAR signaling, DNA replication, and the cell cycle. We also established circRNA–miRNA–mRNA regulatory networks, identifying key regulatory factors and miRNAs. In conclusion, our study offers valuable insights into the complex interplay of circRNA–miRNA–mRNA interactions during goose liver development, and illuminates the molecular pathways that regulate this vital life function.

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Lipidomics analysis reveals new insights into the goose fatty liver formation

Cited by 6 publications

References 37 publications

Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet

Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet

Lipidomics Analysis Deepen Understanding the Molecular Mechanisms in a Gouty Model Induced by Combination of MSU Crystals Injection and High-Fat Diet Feeding and the Intervention Mechanisms of Allopurinol

Molecular Mechanisms of circRNA–miRNA–mRNA Interactions in the Regulation of Goose Liver Development

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