Lipidomic signatures of NAFLD/NASH progression to HCC in a murine model with conditional hepatocyte-specific Pten deletion
Qian Zhou,
Di Mu,
Changfeng Hu
et al.
Abstract:Background Nonalcoholic fatty liver disease (NAFLD) has become a major public health disease in the world, some of these patients will progress to decompensated liver cirrhosis or even liver cancer. To explore the systemic and dynamic lipid metabolic alterations during the pathological progression from NAFLD to spontaneous hepatocellular carcinoma (HCC) in an AlbCrePtenflox/flox mouse model.
Methods A multi-dimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) technology were used to quantify the m… Show more
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