Lipidome profiling of human and equine neutrophil-derived extracellular vesicles and their potential contribution to the ensemble of synovial fluid-derived extracellular vesicles during joint inflammation
Laura Varela,
Sanne Mol,
Esther W. Taanman-Kueter
et al.
Abstract:The molecular signature of cell-derived extracellular vesicles (EVs) from synovial fluid (SF) offers valuable insights into the cells and molecular processes associated with joint disorders and can be exploited to define biomarkers. The signature of EVs is determined by cargo molecules and the lesser-studied lipid bilayer. We here investigated the lipidome of SF-EVs in inflamed joints derived from Rheumatoid Arthritis (RA) and Spondyloarthritis (SpA) patients, two autoimmune-driven joint diseases, and compared… Show more
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