Lipidic lyotropic liquid crystals: Insights on biomedical applications

Blanco-Fernandez, Guillermo; Blanco-Fernandez, Bárbara; Fernández‐Ferreiro, Anxo; Otero-Espinar, Francisco J.

doi:10.1016/j.cis.2023.102867

Cited by 17 publications

(7 citation statements)

References 223 publications

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“…Moreover, various mesophases consist of; lamellar, hexagonal (normal or inverse), and cubic (discontinuous or inverse bicontinuous) phases as depicted in Figure 7 [ 210 ]. Liquid crystals not only have ordered alignment and optical properties like solid crystals, but also have fluidity, viscosity, and surface tension like liquids, and are of two types i.e., lyotropic and thermotropic [ 211 ]. Thermotropic liquid crystals upon temperature change are found in high-melting point ionic molecules without adding any aqueous solvent.…”

Section: Lipid Nanocarriers Mediated Delivery Of Antibiotics and Anti...mentioning

confidence: 99%

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Lipid Nanocarriers-Enabled Delivery of Antibiotics and Antimicrobial Adjuvants to Overcome Bacterial Biofilms

Ahsan,

Thomas,

Barnes

et al. 2024

Pharmaceutics

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The opportunistic bacteria growing in biofilms play a decisive role in the pathogenesis of chronic infectious diseases. Biofilm-dwelling bacteria behave differently than planktonic bacteria and are likely to increase resistance and tolerance to antimicrobial therapeutics. Antimicrobial adjuvants have emerged as a promising strategy to combat antimicrobial resistance (AMR) and restore the efficacy of existing antibiotics. A combination of antibiotics and potential antimicrobial adjuvants, (e.g., extracellular polymeric substance (EPS)-degrading enzymes and quorum sensing inhibitors (QSI) can improve the effects of antibiotics and potentially reduce bacterial resistance). In addition, encapsulation of antimicrobials within nanoparticulate systems can improve their stability and their delivery into biofilms. Lipid nanocarriers (LNCs) have been established as having the potential to improve the efficacy of existing antibiotics in combination with antimicrobial adjuvants. Among them, liquid crystal nanoparticles (LCNPs), liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs) are promising due to their superior properties compared to traditional formulations, including their greater biocompatibility, higher drug loading capacity, drug protection from chemical or enzymatic degradation, controlled drug release, targeted delivery, ease of preparation, and scale-up feasibility. This article reviews the recent advances in developing various LNCs to co-deliver some well-studied antimicrobial adjuvants combined with antibiotics from different classes. The efficacy of various combination treatments is compared against bacterial biofilms, and synergistic therapeutics that deserve further investigation are also highlighted. This review identifies promising LNCs for the delivery of combination therapies that are in recent development. It discusses how LNC-enabled co-delivery of antibiotics and adjuvants can advance current clinical antimicrobial treatments, leading to innovative products, enabling the reuse of antibiotics, and providing opportunities for saving millions of lives from bacterial infections.

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Section: Lipid Nanocarriers Mediated Delivery Of Antibiotics and Anti...mentioning

confidence: 99%

“…These amphiphilic lipids affect the mesophase structure through their molecular shape and concentration. Additionally, external factors like pressure, temperature, and pH are also involved in determining the mesophase [ 211 ].…”

Section: Lipid Nanocarriers Mediated Delivery Of Antibiotics and Anti...mentioning

confidence: 99%

Lipid Nanocarriers-Enabled Delivery of Antibiotics and Antimicrobial Adjuvants to Overcome Bacterial Biofilms

Ahsan,

Thomas,

Barnes

et al. 2024

Pharmaceutics

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“…On the other hand, LCs are found hosting zoos of topological solitons with particle-like behaviour manifesting in the formation of solitonic crystals and unusual forms of active and driven matter [63,172]. From yet another perspective, manifestations of LC behaviour continue being observed in various biological and active matter systems, as well new biomedical applications such as biodetection, drug delivery and cancer treatment [173][174][175][176][177].…”

Section: Statusmentioning

confidence: 99%

Soft matter roadmap^*

Barrat,

Del Gado,

Egelhaaf

et al. 2023

J. Phys. Mater.

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Soft materials are usually defined as materials made of mesoscopic entities, often self-organized, sensitive to thermal fluctuations and to weak perturbations. Archetypal examples are colloids, polymers, amphiphiles, liquid crystals, foams. The importance of soft materials in everyday commodity products, as well as in technological applications, is enormous, and controlling or improving their properties is the focus of many efforts. From a fundamental perspective, the possibility of manipulating soft material properties, by tuning interactions between constituents and by applying external perturbations, gives rise to an almost unlimited variety in physical properties. Together with the relative ease to observe and characterize them, this renders soft matter systems powerful model systems to investigate statistical physics phenomena, many of them relevant as well to hard condensed matter systems. Understanding the emerging properties from mesoscale constituents still poses enormous challenges, which have stimulated a wealth of new experimental approaches, including the synthesis of new systems with, e.g., tailored self-assembling properties, or novel experimental techniques in imaging, scattering or rheology. Theoretical and numerical methods, and coarse-grained models, have become central to predict physical properties of soft materials, while computational approaches that also use machine learning tools are playing a progressively major role in many investigations.This roadmap paper intends to give a broad overview of recent and possible future activities in the field of soft materials, with experts covering various developments and challenges in material synthesis and characterization, instrumental, simulation and theoretical methods as well as general concepts.

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“…2 Selivanova N. M. -experimental analysis, correction of the text material of the article. 3 Galyametdinov Yu.G. -work management, analysis of theoretical material, correction of the textual material of the article.…”

Section: Contribution Of the Authorsmentioning

confidence: 99%

“…Поэтому актуальным направлением биомедицины и фармации является разработка транспортных систем для адресной доставки лекарственных средств (ЛС), обеспечивающих оптимальное проникновение и повышающих биодоступность плохо растворимых или быстро метаболизирующих лекарственных препаратов [2]. Лиотропные жидкокристаллические (ЛЖК) системы открывают новые горизонты в доставке лекарств [3,4] и регенерации тканей [5]. Лиомезофазы хорошо зарекомендовали себя как системы для парентеральной доставки [6], обладая большим потенциалом в этом направлении благодаря аналогии их строения со структурой биологической мембраны и способности к самосборке дифильных молекул в водных и органических средах в надмолекулярные структуры с заданной в макромасштабе организацией [7][8][9].…”

Section: Introductionunclassified

Wetting and Adhesive Properties of Biopolymer-Based Organized Condensed Phases as Drug Delivery Systems

Galeeva,

Selivanova,

Galyametdinov

2023

Liq. Cryst. and their Appl.

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Lyotropic liquid crystalline systems are of great interest as carriers of biological substances for targeted delivery, mainly for transdermal administration of drugs and their application to the skin and mucous membranes. The wetting and adhesive interactions of lyomesophases and gel based on a chitosan polysaccharide in lactic acid solution on a glass substrate (base surface) and the surface of a semi-permeable polytetrafluoroethylene membrane (model of epidermis horny layer) were studied. The effect of the riboflavin drug (vitamin B2) on the surface tension of studied samples and the amount of adhesion work has been established. It is shown that biocompatible chitosan-containing systems can be used as drug carriers for various biomedical purposes, including transdermal drug delivery.

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Lipidic lyotropic liquid crystals: Insights on biomedical applications

Cited by 17 publications

References 223 publications

Lipid Nanocarriers-Enabled Delivery of Antibiotics and Antimicrobial Adjuvants to Overcome Bacterial Biofilms

Lipid Nanocarriers-Enabled Delivery of Antibiotics and Antimicrobial Adjuvants to Overcome Bacterial Biofilms

Soft matter roadmap^*

Wetting and Adhesive Properties of Biopolymer-Based Organized Condensed Phases as Drug Delivery Systems

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Lipidic lyotropic liquid crystals: Insights on biomedical applications

Cited by 17 publications

References 223 publications

Lipid Nanocarriers-Enabled Delivery of Antibiotics and Antimicrobial Adjuvants to Overcome Bacterial Biofilms

Lipid Nanocarriers-Enabled Delivery of Antibiotics and Antimicrobial Adjuvants to Overcome Bacterial Biofilms

Soft matter roadmap*

Wetting and Adhesive Properties of Biopolymer-Based Organized Condensed Phases as Drug Delivery Systems

Contact Info

Product

Resources

About

Soft matter roadmap^*