Lipidic extract of whole tomato reduces hyperplasia, oxidative stress and inflammation on testosterone-induced BPH in obese rats

Colado-Velázquez, Juventino Iii; Mailloux-Salinas, Patrick; Arias-Chávez, David Julian; Ledesma-Aparicio, Jessica; Gómez-Viquez, Norma Leticia; Cano-Europa, Edgard; Sarabia, Gabriel Noris; Bravo, Gerardo Ferrando

doi:10.1007/s11255-022-03383-2

Cited by 2 publications

(8 citation statements)

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“…Aging naturally increases OS, which is related to the pathophysiology of BPH. The accumulated production of reactive oxygen species due to endogenous or exogenous causes, like testosterone, plays a determinant role in diseases such as BPH 5,24 . The antioxidant effect of Se and the tomato extract together would have a positive effect not only on BPH but also in elderly subjects, improving their quality of life compared to finasteride, which would probably worsen OS.…”

Section: Discussionmentioning

confidence: 99%

“…Assays for malondialdehyde (MDA) and nitrites (

{NO}_{2}^{-}

) in prostate samples were performed as previously reported 5 …”

Section: Methodsmentioning

confidence: 99%

“…The increase in prostate size causes bladder obstruction and physical compression of the urethra leading to lower urinary tract symptoms (LUTS) 1–3 . LUTS are the first cause of consultation in urology departments and are strongly associated with benign prostatic hyperplasia (BPH), the most frequent benign tumour in the elderly men >50 years of age 3–5 …”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] LUTS are the first cause of consultation in urology departments and are strongly associated with benign prostatic hyperplasia (BPH), the most frequent benign tumour in the elderly men >50 years of age. [3][4][5] The physiopathology of BPH is unclear. However, aging, hormonal dysregulation, inflammation and oxidative stress (OS) are…”

mentioning

confidence: 99%

“…9,10 Finasteride is the current first-line pharmacological for BPH as it inhibits 5-alpha reductase (5-AR) preventing the conversion of testosterone to DHT which is involved in both normal and abnormal prostate growth. 11,12 Nevertheless, its use generates adverse effects like erectile dysfunction, decreased libido, gynecomastia and psychiatric disorders, 12,13 and although some therapeutic alternatives for BPH have been reported, 5,[14][15][16][17] the search of other treatments is relevant. Selenium (Se) is an important trace element in health because participates in diverse processes as thyroid hormone metabolism, immunity, inflammation, apoptosis, cellular proliferation and antioxidant defence.…”

mentioning

confidence: 99%

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Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations in rats with induced BPH

Arias‐Chávez,

Mailloux‐Salinas,

Ledesma Aparicio

et al. 2023

J Cellular Molecular Medi

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Benign prostatic hyperplasia (BPH) is the most common adenoma in old men. Tomatoes are a rich source of bioactive compounds that, as well as selenium (Se), possess antioxidant and antiproliferative activity. The aim was to evaluate the therapeutic effect of Se in combination with a tomato extract in aged rats with BPH. Aged male Wistar rats were divided in the following groups (n = 10 rats/group): Control (C), BPH, BPH + Finasteride (BPH + F), BPH + Tomato Lipidic Extract (BPH + E), BPH + Selenium (BPH + S) and BPH plus E plus S (BPH + E + S). After 4 weeks of treatment, prostate weight, diuresis, antioxidants enzymes, prooxidants and inflammatory markers, growth factors and androgens were determined. BPH + E + S reduced prostate weight by 59.29% and inhibited growth by 99.35% compared to BPH + F which only decreased weight and inhibited growth by 15.31% and 57.54%, respectively. Prooxidant markers were higher with BPH + F (49.4% higher vs. BPH), but BPH + E + S decreased these markers (94.27% vs. BPH) and increased antioxidant activity. Finally, diuresis was higher with the BPH + E + S combination and markers of inflammation and growth factors were significantly lower with respect to BPH + F. Our findings provide a beneficial and protective therapeutic option of E + S directed against androgens, oxidative stress and inflammation that regulates cell proliferation in the prostate gland.

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Section: Discussionmentioning

confidence: 99%

“…Assays for malondialdehyde (MDA) and nitrites (