Lipid uptake and skin occlusion following topical application of oils on adult and infant skin

Stamatas, Georgios N.; Sterke, Johanna de; Hauser, Matthias; Stetten, Otto von; Pol, A. van der

doi:10.1016/j.jdermsci.2007.11.006

Cited by 122 publications

(136 citation statements)

References 18 publications

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“…In group SSO, however, TEWL interestingly increased in most anatomical areas until D11, followed by a ‘recovery' after the stop of SSO application. Thus, differences in skin barrier function may suggest impaired barrier maturation due to SSO application, which could be linked to the occluding effect of SSO or to the galenic formulation of the oil and its skin penetration properties [11,25,26,27]. Contrary to our findings are the results of recent studies in mice and adults [9,11].…”

Section: Discussioncontrasting

confidence: 99%

Influence of Sunflower Seed Oil on the Skin Barrier Function of Preterm Infants: A Randomized Controlled Trial

Kanti

Grande²,

Stroux³

et al. 2014

Dermatology

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Background: Inadequate skin care may increase morbidity in preterm infants. Skin care practices that support skin maturation have barely been investigated. Objectives: To investigate the effect of sunflower seed oil (SSO) on skin barrier development in low-birth-weight premature infants. Methods: 22 preterm infants (<48 h after birth, 1,500-2,500 g) were randomized into group C (control) and group SSO, receiving daily SSO application during the first 10 postnatal days, followed by no intervention. Transepidermal water loss (TEWL), stratum corneum hydration (SCH), skin pH and sebum were measured <48 h after birth and on postnatal days 5, 11 and 21 on the forehead, abdomen, thigh and buttock. Results: Skin pH decreased, while sebum remained stable in both groups. In group C, TEWL remained stable; in group SSO, TEWL increased significantly on the abdomen, leg and buttock until day 11, followed by a decrease after SSO application had been stopped. Abdomen SCH remained stable in group C, but continuously decreased in group SSO until day 21. Conclusion: SSO application may retard postnatal skin barrier maturation in preterm infants.

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Section: Discussioncontrasting

confidence: 99%

Influence of Sunflower Seed Oil on the Skin Barrier Function of Preterm Infants: A Randomized Controlled Trial

Kanti

Grande²,

Stroux³

et al. 2014

Dermatology

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“…Transepidermal water loss (TEWL) and stratum corneum hydration are measured and compared with the values obtained for petrolatum, known as an occlusive agent with moisturizing properties [21,22,23]. These properties cannot solely be attributed to the fact that petrolatum acts as an inert, occlusive, superficial layer, but are also explained by its penetration into the stratum corneum layers [24,25]. In application experiments TEWL will not only reflect skin barrier efficacy, but also the occlusivity - i.e.…”

Section: Introductionmentioning

confidence: 99%

Silicones as Nonocclusive Topical Agents

Paepe

Sieg²,

Meur³

et al. 2014

Skin Pharmacol Physiol

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Background/Aims: Silicone excipients are commonly used ingredients because of their emollient and skin-conditioning effects, and their ability to form uniform, water-resistant, yet permeable films. Based on comparisons with organic materials and conflicting knowledge from silicones used in scar treatment, the misconception still exists that silicone topical excipients are occlusive substances that may block the passive loss of water through the upper skin layers. Therefore, 3 types of common silicone excipients and 3 water-in-(oil-plus-silicone) or W/(O + Si) creams, containing 10% (w/w) of the respective silicones, were investigated as a function of time and compared to petrolatum. Methods: Transepidermal water loss (TEWL) and skin hydration measurements were carried out after a single topical application on forearm skin of 26 healthy young female volunteers. Results: Both petrolatum and silicones significantly decreased TEWL 15 min after application, but the measurements for the silicones were not significantly different from the untreated control values. The tested silicones did not moisturize the skin. Petrolatum formed an occlusive layer, creating an increase in skin hydration for more than 4 h. The results measured for the W/(O + Si) creams indicated that they moisturized the skin, without any effect on TEWL. Conclusion: A clear difference was shown between the skin occlusive properties of petrolatum and the water vapor permeability of the common silicone excipient materials.

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“…Oil applications moisturize the skin by reinforcing the intercellular lipids of the stratum corneum and, in turn, providing a better barrier function. For instance, in vivo confocal Raman microspectroscopy evaluations have shown that paraffin oil (mineral oil) and vegetable oils can penetrate the top layers of the stratum corneum [22]. The latter measured from the water content profiles the thickness of the stratum corneum after topical applications of different oils.…”

Section: Discussionmentioning

confidence: 99%

TEM Assessments of the Restructuring Effects of an Emollient Cream on the <i>stratum corneum</i>

Fitoussi¹,

Vié²,

Mathieu³

et al. 2011

JCDSA

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Lipid uptake and skin occlusion following topical application of oils on adult and infant skin

Cited by 122 publications

References 18 publications

Influence of Sunflower Seed Oil on the Skin Barrier Function of Preterm Infants: A Randomized Controlled Trial

Influence of Sunflower Seed Oil on the Skin Barrier Function of Preterm Infants: A Randomized Controlled Trial

Silicones as Nonocclusive Topical Agents

TEM Assessments of the Restructuring Effects of an Emollient Cream on the <i>stratum corneum</i>

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Lipid uptake and skin occlusion following topical application of oils on adult and infant skin

Cited by 122 publications

References 18 publications

Influence of Sunflower Seed Oil on the Skin Barrier Function of Preterm Infants: A Randomized Controlled Trial

Influence of Sunflower Seed Oil on the Skin Barrier Function of Preterm Infants: A Randomized Controlled Trial

Silicones as Nonocclusive Topical Agents

TEM Assessments of the Restructuring Effects of an Emollient Cream on the &lt;i&gt;stratum corneum&lt;/i&gt;

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TEM Assessments of the Restructuring Effects of an Emollient Cream on the <i>stratum corneum</i>