Lipid transfer protein–linked hazelnut allergy in children from a non-Mediterranean birch-endemic area

Flinterman, Annebeth E.; Akkerdaas, Jaap H.; Jäger, Cornelie; Rigby, Neil M.; Fernández‐Rivas, Montserrat; Hoekstra, M. O.; Bruijnzeel-Koomen, Carla A.F.M.; Knulst, André C.; Ree, Ronald van; Pasmans, Suzanne G.M.A.

doi:10.1016/j.jaci.2007.10.009

Cited by 83 publications

(82 citation statements)

References 24 publications

(40 reference statements)

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“…Therefore, the impact of antigen dose on sensitization remains unclear. Recently, in contradiction to our study, sensitization to Cor a 8 without IgE reactivity to Pru p 3 was reported in hazelnut-allergic children without any allergic reaction or even without exposure to peach [41]. From these findings we may speculate that Cor a 8 may act as primary sensitizing agent, but it should be considered that the natural Cor a 8 preparation used in that study appeared to contain some impurities which were IgE reactive.…”

Section: Discussioncontrasting

confidence: 99%

Comparison of IgE-Binding Capacity, Cross-Reactivity and Biological Potency of Allergenic Non-Specific Lipid Transfer Proteins from Peach, Cherry and Hazelnut

Hartz

Lauer

Moncín

et al. 2010

Int Arch Allergy Immunol

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Background: Whether the observed clinical pattern of non-specific lipid transfer protein (nsLTP)-mediated food allergies is attributable to a primary sensitization by Pru p 3 from peach and subsequent cross-reactivity with Rosaceae- and non-Rosaceae-derived foods expressing homologous allergens is still unclear. Objective: To investigate the allergenic properties of nsLTPs from Rosaceae and non-Rosaceae foods. Methods: In peach-, cherry- or hazelnut-allergic patients, prevalence of sensitization, IgE-binding capacity, cross-reactivity and allergenic potency of Pru p 3 was compared with Pru av 3 (cherry) and Cor a 8 (hazelnut). Results: Frequency of sensitization to corresponding nsLTPs was 88, 85, and 77% in peach-, hazelnut- and cherry-allergic patients, respectively. Concomitant allergic reactions to cherry and hazelnut were reported in 51 and 44% of peach-allergic patients, respectively. In contrast to cherry allergy, hazelnut allergy was not strictly associated to peach allergy. Sensitization to Cor a 8 or Pru av 3 was strongly correlated with IgE reactivity to Pru p 3, even when subjects tolerated peach. Specific IgE was highest for Rosaceae LTPs, and cross-inhibition experiments confirmed a stronger IgE-binding capacity of Pru p 3 than Cor a 8. The biological potency of Pru p 3 and Pru av 3 was similar but stronger for both nsLTPs than that of Cor a 8. Conclusion: Clinical cross-reactivity of food-allergic patients in the Mediterranean area is likely attributed to a primary sensitization to Pru p 3 and serological cross-reactivity with homologous food nsLTPs. In comparison to Cor a 8, Rosaceae nsLTPs showed a stronger IgE-binding capacity and allergenic potency indicating a different epitope pattern.

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Section: Discussioncontrasting

confidence: 99%

Comparison of IgE-Binding Capacity, Cross-Reactivity and Biological Potency of Allergenic Non-Specific Lipid Transfer Proteins from Peach, Cherry and Hazelnut

Hartz

Lauer

Moncín

et al. 2010

Int Arch Allergy Immunol

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“…The variability of nsLTPs was also shown in the Corylaceae hazelnut nsLTP, Cor a 8, which had poor cross-reactivity with Rosaceae fruit nsLTPs (Flinterman et al, 2008). On the contrary, Artemisia vulgaris pollen grains have cross-reactivity with nsLTPs of Rosaceae fruits (Díaz-Perales et al, 2000;Lombardero et al, 2004).…”

Section: Pollen Vs Nsltp Diversitymentioning

confidence: 89%

An approach to the knowledge of pollen and allergen diversity through lipid transfer protein localisation in taxonomically distant pollen grains

Suárez‐Cervera

Vega-Maray

Castells

et al. 2008

Grana

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“…One further point that deserves to be discussed is the possibility that some patients included into the ‘tree nut’ group were also sensitized to LTP. In fact, a recent study [35] found that children with hazelnut allergy living in non-Mediterranean, birch-endemic areas are sensitized to hazelnut LTP in the absence of peach LTP reactivity. However, this fact has never been observed in Mediterranean countries where peach is the primary sensitizer [28].…”

Section: Discussionmentioning

confidence: 99%

Causes of Food-Induced Anaphylaxis in Italian Adults: A Multi-Centre Study

Asero

Antonicelli

Arena

et al. 2009

Int Arch Allergy Immunol

126

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Background: Data about food-induced anaphylaxis in Italy are missing. Objective: It was the aim of this study to detect the main foods/food allergens causing anaphylaxis in Italy. Methods: The frequency of anaphylaxis and the relative importance of many offending foods were assessed in 1,110 adult patients with food allergy diagnosed by common criteria at 19 allergy centres scattered throughout Italy from 1 January to 31 December 2007. Results: Fifty-eight of 1,110 (5%) food-allergic patients experienced at least 1 episode of anaphylaxis. On average, they were older than other food-allergic patients (34 vs. 31 years; p < 0.05). The majority of anaphylactic episodes occurred in patients sensitized to lipid transfer protein (LTP; n = 19), followed by shrimp (n = 10), tree nuts (n = 9), legumes other than peanut (n = 4), and seeds (n = 2); peanut, spinach, celery, buckwheat, wheat, avocado, tomato, fish, meat, and Anisakis caused an anaphylactic reaction in single patients. Among LTP-hypersensitive patients, peach caused 13/19 anaphylactic episodes. Shrimp-allergic patients were significantly older than other patients with food-induced anaphylaxis (p < 0.05), whereas patients allergic to LTP experienced their anaphylactic episodes at a younger age (p < 0.001). The frequency of anaphylaxis among patients sensitized to LTP, shrimp or tree nuts did not differ between northern and central/southern Italy. Conclusion: LTP is the most important allergen causing food-induced anaphylaxis in Italy, peach being the most frequently offending food. Peanut-induced anaphylaxis seems very uncommon. Geographic and environmental differences both between Italy and other countries and within Italy seem to play a relevant role in the pattern of sensitization to foods.

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Lipid transfer protein–linked hazelnut allergy in children from a non-Mediterranean birch-endemic area

Cited by 83 publications

References 24 publications

Comparison of IgE-Binding Capacity, Cross-Reactivity and Biological Potency of Allergenic Non-Specific Lipid Transfer Proteins from Peach, Cherry and Hazelnut

Comparison of IgE-Binding Capacity, Cross-Reactivity and Biological Potency of Allergenic Non-Specific Lipid Transfer Proteins from Peach, Cherry and Hazelnut

An approach to the knowledge of pollen and allergen diversity through lipid transfer protein localisation in taxonomically distant pollen grains

Causes of Food-Induced Anaphylaxis in Italian Adults: A Multi-Centre Study

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