Lipid transfer protein isolated from noni seeds displays antibacterial activity in vitro and improves survival in lethal sepsis induced by CLP in mice

Souza, Alana Gomes de; Costa, Andréa Santos; Campos, Dyély C.O.; Batista, A.H.M.; Sales, Gleilton Weyne Passos; Nogueira, Nádia Accioly Pinto; Alves, Keila M.M.; Coelho‐de‐Souza, Andrelina Noronha; Oliveira, Hermógenes David de

doi:10.1016/j.biochi.2018.03.011

Cited by 21 publications

(15 citation statements)

References 37 publications

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“…The protective effects of McLTP 1 may be partially exerted through the downregulation of IL-6 and upregulation of IL-10, suggesting a mitigation of kidney inflammation and reduction in inflammatory cell infiltration. The modulation of cytokines by McLTP 1 has also been observed by Campos et al (2017) and Souza et al (2018). Activation of the nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinase signaling pathways by GM leads to increased expression of inflammatory cytokines (Bae et al 2008).…”

Section: Discussionmentioning

confidence: 94%

Protective Effects Of A Lipid Transfer Protein Isolated from Morinda citrifolia Seeds in Gentamicin-Induced Nephrotoxicity in Rats

Silveira

Chaves-Filho

Macêdo

et al. 2020

Rev. Bras. Farmacogn.

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Gentamicin is an aminoglycoside antibiotic used in the treatment of gram-negative bacterial infections. However, its prolonged use is limited due to a high risk of nephrotoxicity. This study aimed to investigate the protective effects of a lipid transfer protein isolated from Morinda citrifolia L., Rubiaceae, seeds against gentamicin-induced nephrotoxicity in rats, and in a proximal tubular epithelial cell line from Rhesus monkey (LLC-MK2). Treatment with 6.25-25 μg/ml of the protein protected cells against cytotoxicity induced by 2 mM gentamicin. In the in vivo study, protein treatment (8 mg/kg, orally administered daily for 7 days 2 h after intraperitoneal injection of 100 mg/kg gentamicin) improved the levels of creatinine, urea, and uric acid. Additionally, it alleviated oxidative stress and inflammation induced by gentamicin, including a reduction in myeloperoxidase activity and cytokine modulation. Data were corroborated with histological analysis showing attenuated alterations by protein treatment. These findings suggest that this protein protects against gentamicin-induced nephrotoxicity. In addition, this natural product may be as an adjunctive tool to reduce kidney toxicity and improve the clinical usage profile of gentamicin.

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Section: Discussionmentioning

confidence: 94%

Protective Effects Of A Lipid Transfer Protein Isolated from Morinda citrifolia Seeds in Gentamicin-Induced Nephrotoxicity in Rats

Silveira

Chaves-Filho

Macêdo

et al. 2020

Rev. Bras. Farmacogn.

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“…These peptides have been shown to reversibly bind and transport hydrophobic molecules in an in vitro model (Carvalho and Gomes 2007). LTPs not only inhibit the growth of fungi and bacteria, but they also participate in plant defense systems (Blein et al 2002;Bogdanov et al 2015Bogdanov et al , 2016Souza et al 2018).…”

Section: Lipid Transfer Proteinsmentioning

confidence: 99%

Plant antimicrobial peptides: structures, functions, and applications

Jian

et al. 2021

Bot Stud

149

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Antimicrobial peptides (AMPs) are a class of short, usually positively charged polypeptides that exist in humans, animals, and plants. Considering the increasing number of drug-resistant pathogens, the antimicrobial activity of AMPs has attracted much attention. AMPs with broad-spectrum antimicrobial activity against many gram-positive bacteria, gram-negative bacteria, and fungi are an important defensive barrier against pathogens for many organisms. With continuing research, many other physiological functions of plant AMPs have been found in addition to their antimicrobial roles, such as regulating plant growth and development and treating many diseases with high efficacy. The potential applicability of plant AMPs in agricultural production, as food additives and disease treatments, has garnered much interest. This review focuses on the types of plant AMPs, their mechanisms of action, the parameters affecting the antimicrobial activities of AMPs, and their potential applications in agricultural production, the food industry, breeding industry, and medical field.

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“…The role of nsLTPs in relation to biotic stresses is well established in the literature, either by direct mechanisms, such as acting as antimicrobial agents, as lipid transporters, or indirectly as signaling molecules [ 4 ], as discussed below. Therefore, plant nsLTPs have become the target of studies involving genetic transformation, aiming at acquiring resistance to pathogens, besides their potential use for drug development, given their potential activity against human pathogens and inhibition of clinical sepsis [ 24 ], as we will discuss later.…”

Section: Roles Of Nsltpsmentioning

confidence: 99%

Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity

et al. 2021

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Lipid transfer proteins (LTPs) are among the most promising plant-exclusive antimicrobial peptides (AMPs). They figure among the most challenging AMPs from the point of view of their structural diversity, functions and biotechnological applications. This review presents a current picture of the LTP research, addressing not only their structural, evolutionary and further predicted functional aspects. Traditionally, LTPs have been identified by their direct isolation by biochemical techniques, whereas omics data and bioinformatics deserve special attention for their potential to bring new insights. In this context, new possible functions have been identified revealing that LTPs are actually multipurpose, with many additional predicted roles. Despite some challenges due to the toxicity and allergenicity of LTPs, a systematic review and search in patent databases, indicate promising perspectives for the biotechnological use of LTPs in human health and also plant defense.

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Lipid transfer protein isolated from noni seeds displays antibacterial activity in vitro and improves survival in lethal sepsis induced by CLP in mice

Cited by 21 publications

References 37 publications

Protective Effects Of A Lipid Transfer Protein Isolated from Morinda citrifolia Seeds in Gentamicin-Induced Nephrotoxicity in Rats

Protective Effects Of A Lipid Transfer Protein Isolated from Morinda citrifolia Seeds in Gentamicin-Induced Nephrotoxicity in Rats

Plant antimicrobial peptides: structures, functions, and applications

Lipid Transfer Proteins (LTPs)—Structure, Diversity and Roles beyond Antimicrobial Activity

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