Lipid Transfer in Oil-in-Water Isasome Emulsions: Influence of Arrested Dynamics of the Emulsion Droplets Entrapped in a Hydrogel

Abstract

The transfer kinetics of lipids between internally self-assembled droplets of O/W emulsions is studied. The droplets (isasomes) consist of various liquid-crystalline phases or W/O microemulsions stabilized by a polymeric stabilizer F127. The various internal phases were identified by the relative peak positions in the small-angle X-ray scattering (SAXS) curves. An arrested system composed of isasomes embedded in a gel matrix actually provides an additional possibility to control these systems in terms of the release of various host molecules. These experiments have been applied to examine the kinetics of the internal phase reorganization imposed by the lipids' release and uptake by the droplets embedded in a κ-carrageenan (KC) hydrogel network. Increasing the concentration of the gelling agent slows down the transfer from one droplet to the other through the aqueous phase. We examined the region where the free diffusion is stopped. i.e., the point where the system changes from the ergodic to the nonergodic state and the kinetics is essentially slowed down. This effect can be balanced by the addition of small amounts of free polymeric stabilizer, which speeds up the kinetics. This is even possible in the case of highly arrested dynamics of the emulsion droplets, as found for the highest KC hydrogel concentrations forming nonergodic systems.

Supramolecular structure of methyl cellulose and lambda- and kappa-carrageenan in water: SAXS study using the string-of-beads model

“…We now report the corresponding viscosity results and the ones obtained for LC samples in the related article (Cerar et al, 2017). It might also be of interest that some of these polymeric materials were already successfully tested as arresting media for various hierarchically structured internally self-assembled emulsion droplets ISAsomes Iglesias, Pirolt, Sadeghpour, Tomšič, & Glatter, 2013;Iglesias, Pirolt, Tomsic, & Glatter, 2015;Kulkarni, Tomšič, & Glatter, 2011;Tomšič et al, 2009 approximately 70 °C to melt the gel before such dilution. Deionized Milipore-quality water was used for the sample preparations.…”

“…Deionized Milipore-quality water was used for the sample preparations. We have followed this procedure, because in a number of our previous studies it ensured well dissolved polymer samples and reproducible results on various studied properties of these and related systems Iglesias et al, 2013;Iglesias et al, 2015;Kulkarni et al, 2011;Tomšič et al, 2009;Tomšič et al, 2008).…”

Physicochemical data on aqueous polymeric systems of methyl cellulose and lambda- and kappa-carrageenan: SAXS, rheological, densitometry, and sound velocity measurements

“…The data shown in this article are related to our recent structural study of aqueous polymer systems of methyl cellulose (MC), carrageenan (LC), and carrageenan (KC) utilizing the small-angle scattering (SAXS) study by the string-of-beads model [1] and on a general level in part also to some of our previous studies [2] , [3] , [4] , [5] , [6] , [7] , [8] . Some of them represent the basic polymer characterization and the others contain additional information on practically very important dynamic and structural properties of these systems.…”

Lyotropic Liquid Crystalline Phases for the Formulation of Future Functional Foods

“…7 Later in 1996, Landh and Larsson patented the preparation of particles comprising different types of liquid crystalline phases in their interiors. 8 These stabilized particles with Internally Self-Assembled mesophases are sometimes referred to as ISAsomes [9][10][11] or as in this review simply termed as mesosomes. Applications of the LLC bicontinuous cubic phase containing mesosomes (cubosomes) and the inverted hexagonal phase based mesosomes (hexosomes) have received considerable attention in recent years.…”