Lipid Synthesis, Intracellular Transport, and Secretion

Stein, O.; Stein, Y.

doi:10.1083/jcb.34.1.251

Cited by 123 publications

(45 citation statements)

References 25 publications

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“…Several sources of pre-formed fatty acids are available from the plasma: VLDL particles synthesized by the liver or chylomicra bearing triglycerides absorbed from the diet interact with lipoprotein lipase, present on capillary walls, which hydrolyzes the triglycerides into fatty acids and glycerol; these are then taken up into the alveolar cell for incorporation into the cytoplasmic lipid droplet [26], a process which appeared to take place in the endoplasmic reticulum [27].…”

Section: Morphological Studiesmentioning

confidence: 99%

Classic Studies of Mammary Development and Milk Secretion: 1945 – 1980

Neville¹

2009

J Mammary Gland Biol Neoplasia

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On June 20, 1947 a meeting at the Royal Society of Medicine in London was entitled "Discussion on Some Recent Developments in Knowledge of the Physiology of the Breast" [1]. The major questions outlined by the speakers were: how does the structure of the breast change with reproductive stage? what is the role of the basal cell layer in the mammary epithelium? how is milk composition related to diet? and what is the basic physiology of milk secretion including its hormonal regulation? All these questions were attacked vigorously in laboratories mostly in England and the United States, but researchers in France, Germany, and Austria also weighed in. Our purpose in this edition of the Journal is to show, through the presentation of seminal papers and key references, how the research of that period, prior to the molecular revolution of the last three decades, laid the groundwork for our current understanding of the morphology, developmental biology, and physiology of the functional mammary gland. This knowledge provides the groundwork for our current research into the molecular mechanisms involved in milk secretion and its regulation.

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Section: Morphological Studiesmentioning

confidence: 99%

Classic Studies of Mammary Development and Milk Secretion: 1945 – 1980

Neville¹

2009

J Mammary Gland Biol Neoplasia

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“…El lugar exacto dentro del RER donde se lleva a cabo la conformación del NGG no es muy claro (12), pero se sabe que son liberados en el citosol de la célula epitelial mamaria (MEC, por su sigla en inglés) cuando tienen menos de 0.5 μm de diámetro, de forma directa y no a través del aparato de golgi como sucede con la caseína ó las lipoproteínas en el hígado (13). Al salir al citosol, los NGG quedan revestidos con proteínas y lípidos de la membrana reticular, formando a su alrededor una monocapa en la que predominan fosfatidil y lisofosfatidil colina, y constituyendo lo que se conoce como microdroplet (Figura 2 #1) (11).…”

Section: Composición Lipídica De La Leche Bovina Y Estructura Del Glóunclassified

Síntesis, composición y modificación de la grasa de la leche bovina: Un nutriente valioso para la salud humana

A¹,

L²,

A³

2009

Rev MVZ Córdoba

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RESUMENSe presenta una revisión sobre la composición, estructura y mecanismo de síntesis de la grasa de la leche en la glándula mamaria bovina y del efecto de la suplementación con ácidos grasos insaturados (AGI) sobre la cantidad y calidad de la grasa. Se resalta la importancia de la suplementación con aceites vegetales más aceite de pescado; se sugiere no generalizar el efecto de AGI como negativo sobre la cantidad de grasa de la leche; se muestra la necesidad de relacionar diferentes AGI con la vía regulatoria SREBP y con diferentes enzimas lipogénicas; y se incentiva la investigación del efecto de AGI sobre la composición de ácidos grasos de la leche y su distribución posicional dentro de la estructura lipídica.Palabras clave: Ácidos grasos, glándula mamaria, lípidos, vacas. ABSTRACTIt presents a review about the composition, structure and mechanism of milk fat synthesis in the bovine mammary gland, and about the effect of unsaturated fatty acid (UFA) supplementation on the amount and quality of milk fat. It is enhanced the importance of the supplementation with vegetable plus fish oils; it is suggested that the effect of UFA should not be remarked as negative on the amount of milk fat; It is showed the necessity of relating different UFA with the SREBP´s regulatory way, and with different lipid enzymes; and it is promoted research about the effect of UFA on the milk fatty acid composition and their positional distribution into the lipid structure.

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“…Occasionally, lipid vesicles are closely associated with mitochondria (5,7,24), endoplasmic reticulum (22,23,24), or other lipid vesicles (13), but most often they appear free in the cell cytoplasm . Some lipid vesicles may be equivalent to the spherosomes seen by light microscopy (2,8,11,(19)(20)(21)25), thus implying that these vesicles have a lysosomal function as well as acting simply as a pool of reserve lipid .…”

Section: Introductionmentioning

confidence: 99%

Studies on Seeds

Mollenhauer

Totten

1971

The Journal of Cell Biology

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At least two kinds of lipid vesicles are present in pea and bean cotyledons which can be recognized at seed maturity on the basis of whether they do or do not interassociate into lipid vesicle sheets . Those that do interassociate into sheets are also characterized by (a) their association with plastids or plasma membranes during dormancy, and (b) the unique transformation into flattened saccules that they undergo during the first few days of seed germination . These interassociated (or composite) lipid vesicles have been found in only a few seeds and may be restricted to certain classes of plants and/or certain states of cellular development .Lipid vesicle-to-saccule transformation is predominantly confined to the germinating seed . However, some lipid vesicle-derived saccules are already present in some cells even before the seed reaches maturity . These partially transformed vesicles and saccules remain unchanged over dormancy, and then resume their transformation when the seed is germinated . This suggests that some stages of seed germination are already underway before the seed reaches maturity and are only resumed at seed germination .The lipid vesicles that do not interassociate into sheets (i.e ., the simple lipid vesicles) are present in all tissues at all states of cellular development . These vesicles do not undergo any conspicuous structural changes during development .

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Lipid Synthesis, Intracellular Transport, and Secretion

Cited by 123 publications

References 25 publications

Classic Studies of Mammary Development and Milk Secretion: 1945 – 1980

Classic Studies of Mammary Development and Milk Secretion: 1945 – 1980

Síntesis, composición y modificación de la grasa de la leche bovina: Un nutriente valioso para la salud humana

Studies on Seeds

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