Lipid‐suppressed and tissue‐fraction corrected metabolic distributions in human central brain structures using 2D <sup>1</sup>H magnetic resonance spectroscopic imaging at 7 T

Bhogal, Alex A.; Broeders, Tommy A.A.; Morsinkhof, Lisan; Edens, Mirte; Nassirpour, S; Chang, P; Klomp, Dennis W. J.; Vinkers, Christiaan H.; Wijnen, Jannie P.

doi:10.1002/brb3.1852

Cited by 16 publications

(24 citation statements)

References 65 publications

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“…Comparison with the literature is difficult, as most studies report intra-subject T A B L E 8 Comparison of this study's metabolite ratios and standard deviations of tCho, Glu, Glu + Gln, NAA + NAAG, Ins + Gly, and GSH to tCr in six ROIs compared with similar 7 T MRSI results of Reference. 70 The results of our study are consistently higher for all except GSH/tCr, with two higher/lower/same ratio regions each or inter-system CVs, such as van de Bank et al, 68 who reported CVs for SVS on four different 7 T systems in the posterior cingulate cortex of 3-4% for NAA, tCho, tCr, mIns, and Glu, 22.2% for GABA, 14.4% for GSH, and 8.8% for Gln. Another example, but at 3 T, is the study by Zhang et al, 73 who calculated intra-subject CVs for whole-brain EPSI in 10 volunteers over three scans in 47 ROIs and found NAA CVs of 3.3%-17.8%, tCho CVs of 3.7%-31.0%, tCr CVs of 3.1%-18.0% (with mean ROI CVs < 10%), and mIns CVs of 5.9%-54.0%.…”

Section: Discussionmentioning

confidence: 99%

Inter‐subject stability and regional concentration estimates of 3D‐FID‐MRSI in the human brain at 7 T

et al. 2021

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Purpose: Recently, a 3D-concentric ring trajectory (CRT)-based free induction decay (FID)-MRSI sequence was introduced for fast high-resolution metabolic imaging at 7 T. This technique provides metabolic ratio maps of almost the entire brain within clinically feasible scan times, but its robustness has not yet been thoroughly investigated. Therefore, we have assessed quantitative concentration estimates and their variability in healthy volunteers using this approach.Methods: We acquired whole-brain 3D-CRT-FID-MRSI at 7 T in 15 min with 3.4 mm nominal isometric resolution in 24 volunteers (12 male, 12 female, mean age 27 ± 6 years). Concentration estimate maps were calculated for 15 metabolites using internal water referencing and evaluated in 55 different regions of interest (ROIs) in the brain. Data quality, mean metabolite concentrations, and their inter-subject coefficients of variation (CVs) were compared for all ROIs.Results: Of 24 datasets, one was excluded due to motion artifacts. The concentrations of total choline, total creatine, glutamate, myo-inositol, and N-acetylaspartate in 44 regions were estimated within quality thresholds. Inter-subject CVs (mean over

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Section: Discussionmentioning

confidence: 99%

Inter‐subject stability and regional concentration estimates of 3D‐FID‐MRSI in the human brain at 7 T

et al. 2021

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“…The production of metabolite maps registered to standardized brain atlases, such as the MNI152 brain atlas, is required to facilitate group-based statistical analysis (Bhogal et al, 2020) or to analyze spectroscopic data along with other MR images, such as arterial spin labeling (ASL) MRI (Cengiz, et al, 2017, Cengiz, et al, 2018. FSL-MRS, Osprey, and MRSpant co-register MRS data onto the reference anatomical MRI to compute the CSF fraction and correct for it, but they currently do not support metabolite map generation, registration onto a common brain atlas, and ROI analysis.…”

Section: Discussionmentioning

confidence: 99%

ORYX-MRSI: A Fully-Automated Open-Source Software for Three-Dimensional Proton Magnetic Resonance Spectroscopic Imaging Data Analysis

Cengiz

Yıldırım

Baş

et al. 2021

Preprint

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Proton magnetic resonance spectroscopic imaging (1H-MRSI) provides noninvasive evaluation of brain metabolism. However, there are some limitations of 1H-MRSI preventing its wider use in the clinics, including the spectral quality issues, partial volume effect and chemical shift artifact. Additionally, it is necessary to create metabolite maps for analyzing spectral data along with other MRI modalities. In this study, a MATLAB-based open-source data analysis software for 3D 1H-MRSI, called Oryx-MRSI, which includes modules for visualization of raw 1H-MRSI data and LCModel outputs, chemical shift correction, tissue fraction calculation, metabolite map production, and registration onto standard MNI152 brain atlas while providing automatic spectral quality control, is presented. Oryx-MRSI implements region of interest analysis at brain parcellations defined on MNI152 brain atlas. All generated metabolite maps are stored in NIfTI format. Oryx-MRSI is publicly available at https://github.com/sevimcengiz/Oryx-MRSI along with six example datasets.

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“…MRSI methodology was used as previously published. 24 In short, data were acquired using a 7 tesla MR scanner (Phillips, Best, NL) equipped with a dual-transmit head coil and 32-channel receive coil (Nova Medical, Wilmington Ma, USA). Second order image-based shimming was performed for all acquisitions.…”

Section: Methodsmentioning

confidence: 99%

“…Full spectral reconstruction and post-processing as well as metabolite map and quality assurance map generation details as previously published. 24 Region of interest masks of brain regions from which sufficient coverage was attained (i.e. the Caudate, Putamen, Thalamus and Pallidum) were generated using MNI tissue fraction maps ( Figure 1A ) using FSL (FMRIB).…”

Section: Methodsmentioning

confidence: 99%

Glutamate levels across deep brain structures in patients with a psychotic disorder and its relation with cognitive functioning

Broeders

Bhogal

Morsinkhof

et al. 2021

Preprint

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Patients with psychotic disorders often show prominent cognitive impairment. Glutamate seems to play a prominent role, but knowledge on its role in deep gray matter regions is limited and previous studies have yielded heterogeneous results. The aim was to evaluate glutamate levels within deep gray matter structures in patients with a psychotic disorder in relation to cognitive functioning, using advanced spectroscopic acquisition, reconstruction and post-processing techniques. A 7 tesla MRI scanner combined with a unique lipid suppression coil and subject specific water signal suppression pulses were used to acquire high-resolution magnetic resonance spectroscopic imaging data. Anatomical scans were used to perform tissue fraction correction and registration to a standard brain for group comparison in specifically delineated brain regions. The brief assessment of cognition in schizophrenia was used to evaluate cognitive status. Average glutamate levels across deep gray matter structures (i.e. caudate, pallidum, putamen, and thalamus) in patients with a psychotic disorder (n=16, 4 females) were lower compared to healthy controls (n=23, 7 females). Stratified analyses showed lower glutamate levels in the caudate and putamen but not in the pallidum or thalamus. Average glutamate levels across deep gray matter structures were positively correlated with cognition, particularly to psychomotor speed. We find reduced glutamate levels across deep brain structures such as the caudate and putamen in patients with a psychotic disorder that are linked to psychomotor speed. Our results underscore the potential role of detailed in vivo glutamate assessments to understand cognitive deficits in patients with psychotic disorders.

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Lipid‐suppressed and tissue‐fraction corrected metabolic distributions in human central brain structures using 2D ¹H magnetic resonance spectroscopic imaging at 7 T

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 16 publications

References 65 publications

Inter‐subject stability and regional concentration estimates of 3D‐FID‐MRSI in the human brain at 7 T

Inter‐subject stability and regional concentration estimates of 3D‐FID‐MRSI in the human brain at 7 T

ORYX-MRSI: A Fully-Automated Open-Source Software for Three-Dimensional Proton Magnetic Resonance Spectroscopic Imaging Data Analysis

Glutamate levels across deep brain structures in patients with a psychotic disorder and its relation with cognitive functioning

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Lipid‐suppressed and tissue‐fraction corrected metabolic distributions in human central brain structures using 2D 1H magnetic resonance spectroscopic imaging at 7 T

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 16 publications

References 65 publications

Inter‐subject stability and regional concentration estimates of 3D‐FID‐MRSI in the human brain at 7 T

Inter‐subject stability and regional concentration estimates of 3D‐FID‐MRSI in the human brain at 7 T

ORYX-MRSI: A Fully-Automated Open-Source Software for Three-Dimensional Proton Magnetic Resonance Spectroscopic Imaging Data Analysis

Glutamate levels across deep brain structures in patients with a psychotic disorder and its relation with cognitive functioning

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Product

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Lipid‐suppressed and tissue‐fraction corrected metabolic distributions in human central brain structures using 2D ¹H magnetic resonance spectroscopic imaging at 7 T