Lipid-soluble green tea extract: Genotoxicity and subchronic toxicity studies

Zheng, Lina; Li, Dongying; Cheng, Jianguo; Song, Moshi; Fu, Ying; WeiQi, Lai; Yin, Wang; Xu, Yong; Vo, Trung D.; Lynch, Barry

doi:10.1016/j.yrtph.2017.04.004

Cited by 9 publications

(12 citation statements)

References 44 publications

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“…Finally, it is paramount to validate the most promising in vitro data using in vivo models, like toxicologically treated [54,87] or disease-specific [51,56] rodents that could be fed with the original foods, extracts, or isolated bioactive polyphenol molecules. This is also fundamental in assessing the in vivo side effects of polyphenols, particularly in situations mentioned above, and to ascertain the safe usage of any proposed polyphenol [88][89][90][91]. Ultimately, results of in vitro studies, as well as those from animal models, have to be validated by a human pilot study where the beneficial vs. deleterious effects can be monitored, eventually proceeding to clinical trials [92].…”

Section: Neurotoxicity Vs Neuroprotectionmentioning

confidence: 99%

Polyphenols from Food and Natural Products: Neuroprotection and Safety

2020

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Polyphenols are naturally occurring micronutrients that are present in many food sources. Besides being potent antioxidants, these molecules may also possess anti-inflammatory properties. Many studies have highlighted their potential role in the prevention and treatment of various pathological conditions connected to oxidative stress and inflammation (e.g., cancer, and cardiovascular and neurodegenerative disorders). Neurodegenerative diseases are globally one of the main causes of death and represent an enormous burden in terms of human suffering, social distress, and economic costs. Recent data expanded on the initial antioxidant-based mechanism of polyphenols’ action by showing that they are also able to modulate several cell-signaling pathways and mediators. The proposed benefits of polyphenols, either as protective/prophylactic substances or as therapeutic molecules, may be achieved by the consumption of a natural polyphenol-enriched diet, by their use as food supplements, or with formulations as pharmaceutical drugs/nutraceuticals. It has also been proved that the health effects of polyphenols depend on the consumed amount and their bioavailability. However, their overconsumption may raise safety concerns due to the accumulation of high levels of these molecules in the organism, particularly if we consider the loose regulatory legislation regarding the commercialization and use of food supplements. This review addresses the main beneficial effects of food polyphenols, and focuses on neuroprotection and the safety issues related to overconsumption.

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Section: Neurotoxicity Vs Neuroprotectionmentioning

confidence: 99%

Polyphenols from Food and Natural Products: Neuroprotection and Safety

2020

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“…Consumption of tea has been reported with few adverse events [127,148,236]. Tumorigenic, mutagenic, teratogenic, and sub-chronic toxicity of tea-related ingredients have not been observed in animal experiments and human studies, and the no-observed-adverse-effect level (NOAEL), observed safety level, and tolerable upper intake level were far from the functional doses [26,222,223,237]. However, some compounds contained in tea has been recognized as anti-nutritive factors.…”

Section: Potential Safety Issuesmentioning

confidence: 99%

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Tang

Meng

Gan

et al. 2019

IJMS

242

150

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Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the bioavailability of tea phytochemicals is relatively low. Thus, some novel technologies like nanotechnology have been developed to improve the bioavailability of tea bioactive components and consequently enhance the bioactivity. So far, many studies have demonstrated that tea shows various health functions, such as antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity, and hepato-protective effects. Moreover, it is also considered that drinking tea is safe to humans, since reports about the severe adverse effects of tea consumption are rare. In order to provide a better understanding of tea and its health potential, this review summarizes and discusses recent literature on the bioactive components, bioavailability, health functions, and safety issues of tea, with special attention paid to the related molecular mechanisms of tea health functions.

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“…No deaths or obvious clinical signs no differences in organ weight, body weight gain, and food consumption no changes in biochemical and hematological parameters no lesion-inducing effects in organs (Liu et al, 2017) 0.125, 0.25, and 0.5 g/kg/day for 90 days, gavage…”

Section: Green Tea Extractmentioning

confidence: 99%

“…Another studies revealed the safety of lipid‐soluble GT extract (composed of catechin mono‐, di‐, and tri‐palmitates [66–80%], palmitic acid [12–15%], free catechins, gallic acid, alkaloids [1–2%]) and aqueous extract of tea flowers in rats. Administration of lipid‐soluble extract to rats for 30 (2.3 g/kg/day) and 90 days (0.5 g/kg/day) had no toxic effects (Liu et al, ). Furthermore, the aqueous extract of tea flower was safe up to 4 g/kg/day, for 13 weeks, where its NOAEL reported 4 g/kg/day (Li et al, ).…”

Section: Toxicological Findingsmentioning

confidence: 99%

“…Based on the literate review, GT and its main constituents possess negative result in Ames test (Chang et al, 2003;Isbrucker, Bausch, Edwards, & Wolz, 2006;Li et al, 2011;Liu et al, 2017;Ogura et al, 2008) and mammalian erythrocyte micronucleus test (Bazzaz et al, 2016;Isbrucker et al, 2006). Comet assay test demonstrates that EGCG induces DNA damage in a dose-dependent manner (Bertram, Bollow, Rajaee-Behbahani, Bürkle, & Schmezer, 2003).…”

Section: Mutagenicity Genotoxicity Carcinogenicity and Developmementioning

confidence: 99%

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Toxicological effects of Camellia sinensis (green tea): A review

Bedrood

Rameshrad

Hosseinzadeh

2018

Phytotherapy Research

109

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Many scientific articles proved that green tea (GT), Camellia sinensis, has a great potential to manage central nervous system, cardiovascular, and metabolic diseases and treat cancer and inflammatory disorders. However, it is important to consider that "natural" is not always "safe." Some relevant articles reported side effects of GT, detrimental effects on health. The aim of this study is to provide a classified report about the toxicity of GT and its main constituents in acute, subacute, subchronic, and chronic states. Furthermore, it discusses on the cytotoxicity, genotoxicity, mutagenicity, carcinogenicity, and developmental toxicity of GT and its main constituents. The most important side effects have been reported hepatotoxicity and gastrointestinal disorders specially while consumed on an empty stomach. GT and its main components are not major teratogen, mutagen, or carcinogen substances. However, there is limited data in using them during pregnancy, and they should be used with caution in pregnancy, breast-feeding, and susceptible people. Because GT and its main components have a wide variety of drug interactions, consideration should be taken in coadministration of them with narrow therapeutic indexed drugs. Furthermore, they evoke selective cytotoxicity on cancerous cells that could engage them as an adjuvant substance in cancer therapy.

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Lipid-soluble green tea extract: Genotoxicity and subchronic toxicity studies

Cited by 9 publications

References 44 publications

Polyphenols from Food and Natural Products: Neuroprotection and Safety

Polyphenols from Food and Natural Products: Neuroprotection and Safety

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Toxicological effects of Camellia sinensis (green tea): A review

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