Lipid-secreting mammary carcinoma.Report of a case associated with paget's disease of the nipple

Aboumrad, Michel H.; Horn, Robert C.; Fine, Gerald

doi:10.1002/1097-0142(196304)16:4<521::aid-cncr2820160414>3.0.co;2-b

Cited by 78 publications

(34 citation statements)

References 2 publications

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“…Only a few cases are reported in the literature (Wrba et al,1988). Lipidrich carcinoma was first described in women by Aboumrad et al (1963). Some authors thought that the lipid droplets were produced and secreted by the tumour cells instead of being the result of regressive degeneration because lipid droplets existed uniformly in metastasized lymph nodes and in tumor cells undergoing mitosis (Reis-Filho et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

A Metastatic Lipid-Rich Carcinoma of the Mammary Gland in a Female Cat: Clinicopathological, Histopathological and Immunohistochemical Features

Gal¹,

Cătoi²,

Taulescu³

et al. 2017

BUASVMCN-VM

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Lipid-rich invasive human breast cancer is a rare enigmatic entity among special types of infiltrating duct carcinoma. Our paper reports a lipid-rich mammary carcinoma in a female cat with the gross, microscopic and immunohistochemical description of the tumor. A 13-year-old intact adult female, mixed-breed cat was presented by the owner to the Laboratory of Pathologic Anatomy from the Faculty of Veterinary Medicine ClujNapoca, Romania. A complete necropsy examination was performed in our laboratory. The tissue samples were collected and processed by paraffin technique for further histological, histochemical, immunofluorescence and immunohistochemical examination. During the necropsy examination, a subcutaneous mass was discovered on the chest. Several variably sized, well-demarcated neoplasms were noted in the right axillary lymph node, right thoracic wall, pleura, lungs, liver, spleen and kidney. Histologically, the cells frequently formed tubuloacinar structures. The morphology of the described tumor showed features of a poorly differentiated mammary carcinoma. Numerous tumoral cells were large and polygonal, with abundant cytoplasm that showed foam-like cytoplasm. The tumoral cells contained either multiple small or large and solitary vacuoles that pushed the nucleus to the periphery of the cell. Intracytoplasmic vacuoles of the neoplastic cells were positive for Oil-Red-O and negatively with Periodic Acid-Schiff. As for immunofluorescence/immunohistochemistry, nonvacuolated and vacuolated neoplastic cells were positive for cytokeratin and negative for vimentin. Histochemical and immunohistochemical analysis support a diagnosis of lipid-rich mammary carcinoma. This is the second reliable record of a lipid-rich mammary carcinoma in female cat and the first one with internal metastases.

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Section: Introductionmentioning

confidence: 99%

A Metastatic Lipid-Rich Carcinoma of the Mammary Gland in a Female Cat: Clinicopathological, Histopathological and Immunohistochemical Features

Gal¹,

Cătoi²,

Taulescu³

et al. 2017

BUASVMCN-VM

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“…4,16 The morphological features of this neoplasm were first described in a human patient in 1963. 1 However, because of the great rarity of this neoplasm, many aspects of its pathology remain to be elucidated. In the veterinary literature, lipid-rich mammary carcinoma has been recognized as a rare neoplasm in 12 female dogs 5,[11][12][13] and 1 female cat.…”

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confidence: 99%

Lipid-Rich Carcinoma in the Mammary Gland of a Djungarian Hamster (Phodopus Sungorus)

et al. 2010

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Abstract. A lipid-rich carcinoma of the mammary gland was diagnosed in a female Djungarian hamster (Phodopus sungorus), which was kept as an indoor pet. The animal underwent surgery for a primary tumor arising in the mammary gland at the age of 16 months, and also for a recurrent tumor 6 months later. Histologically, the primary neoplasm was composed of 2 different cell populations: nonvacuolated glandular neoplastic cells with moderate atypia, and vacuolated neoplastic cells with marked atypia. Transition from the nonvacuolated glandular cells to the vacuolated cells was frequently seen. The recurrent neoplasm was composed predominantly of vacuolated neoplastic cells that often invaded the surrounding soft tissue. The cytoplasmic vacuoles contained neutral lipids, as confirmed by oil red O and Nile blue staining. The vacuolated neoplastic cells were immunopositive for cytokeratin and negative for vimentin, a-smooth muscle actin, p63, estrogen receptor a, and androgen receptor. Presumably, this high-grade, lipid-rich mammary carcinoma had developed from a low-grade mammary adenocarcinoma.Key words: Djungarian hamster; immunohistochemistry; lipid-rich carcinoma; mammary tumor; Phodopus sungorus.In human medicine, lipid-rich carcinoma is a rare variant of invasive breast carcinoma in which tumor cells contain abundant cytoplasmic neutral lipids. 4,16 The morphological features of this neoplasm were first described in a human patient in 1963.1 However, because of the great rarity of this neoplasm, many aspects of its pathology remain to be elucidated. In the veterinary literature, lipid-rich mammary carcinoma has been recognized as a rare neoplasm in 12 female dogs 5,11-13 and 1 female cat. The Djungarian hamster (Phodopus sungorus), also known as the Dzhungarian hamster, Siberian dwarf hamster, or Russian dwarf hamster, is a popular, indoor small pet in Japan. This species is also used as a laboratory animal, although it is used less often than the Syrian hamster (Mesocricetus auratus). In Djungarian hamsters, mammary tumor is one of the most common spontaneous neoplasms, 3,7,8,14,18 and androgen-dependent atypical fibromas are likewise known to arise in the skin with aging. 2 A female Djungarian hamster, which weighed 52 g at the age of 16 months and was kept as an indoor pet, developed a subcutaneous mass at the site of the fourth mammary gland on the left side. At 9 months of age, this hamster had undergone surgery to excise a neoplasm in the first left mammary gland. This neoplasm had been diagnosed as an adenocarcinoma. The present mass in the fourth left mammary gland (the primary tumor) was surgically excised. It measured 2.0 cm 3 1.5 cm 3 1.5 cm and weighed 1.7 g. When the animal was 22 months old and weighed 53 g, the neoplasm in the fourth left mammary gland recurred and was surgically excised again. This mass measured 2.2 cm 3 2.0 cm 3 1.9 cm and weighed 3.9 g. Further follow-up clinical data on the hamster could not be obtained.On gross examination, both the primary and the recurrent neoplasms were bro...

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“…Lipid-secreting carcinoma was first described in a case report by Aboumrad et al [1]. They observed that lipids can be present in normal mammary ductal epithelial cells and in carcinoma cells.…”

Section: Discussionmentioning

confidence: 97%

“…A certain level of lipids is commonly present in the cytoplasm of breast cancer cells. Lipid-secreting carcinoma, however, is classified as a specific histological type of breast carcinoma according to the 2003 World Health Organization (WHO) classification, and it accounts for approximately 0.09-1.5% of all breast cancers [1][2][3][4]. The tumor cell shows marked amounts of vacuolated or foamy lipids in the cytoplasm [4].…”

Section: Introductionmentioning

confidence: 99%

A non-invasive form of lipid-secreting carcinoma of the breast

et al. 2010

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Lipid-secreting carcinoma is a rare variant of breast carcinoma. The tumor cells possess abundant vacuolated cytoplasm containing neutral fat. A 68-year-old Japanese female patient presented with a left breast tumor, which was detected by mass screening, and she was admitted to our hospital. The physical examination revealed an elastic hard lump in the left lateral quadrant of the left breast. The tumor size was 1.2 × 1.0 cm in diameter and the borderline was unclear. There were no palpable axillary lymph nodes or supraclavicular nodes. Mammography showed a polygonal mass with microcalcification. Ultrasonography indicated a hypoechoic lesion measuring 9 × 4 mm in diameter, with an irregularly shaped, slightly indistinct surface. The internal echoic level of the mass was heterogenous. Enhanced magnetic resonance imaging revealed a mass of high intensity in the left breast, and the connection of the intraductal spread was not detected. The time-intensity curve showed a peak-and-plateau pattern. Fine-needle aspiration cytology suggested a malignant tumor. The patient underwent a partial resection of the left breast (breast-conserving therapy) and a left axillary lymphadenectomy. Macroscopically, the resected specimen revealed a white tumor measuring approximately 0.6 × 0.5 cm. Histopathologically, the tumor measured up to approximately 0.9 × 0.7 cm because of additional components of intraductal spread and therefore was diagnosed as an extensive ductal carcinoma in situ with focal mass formation; the tumor also had abundant foamy cytoplasm. Oil-red-O staining confirmed the presence of marked cytoplasmic lipid droplets. These droplets were periodic acid-Schiff (PAS) negative even after diastase digestion, and negative with PAS-Alcian blue staining. In immunohistochemistry, these carcinoma cells were positive for E-cadherin. Thus, the pathological diagnosis was a non-invasive form of lipid-secreting carcinoma. The tumors were negative for both estrogen receptors and progesterone receptors. There were no metastases in the left axillary lymph nodes. The patient has remained well for 8 years without any evidence of recurrence.

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Lipid-secreting mammary carcinoma.Report of a case associated with paget's disease of the nipple

Cited by 78 publications

References 2 publications

A Metastatic Lipid-Rich Carcinoma of the Mammary Gland in a Female Cat: Clinicopathological, Histopathological and Immunohistochemical Features

A Metastatic Lipid-Rich Carcinoma of the Mammary Gland in a Female Cat: Clinicopathological, Histopathological and Immunohistochemical Features

Lipid-Rich Carcinoma in the Mammary Gland of a Djungarian Hamster (Phodopus Sungorus)

A non-invasive form of lipid-secreting carcinoma of the breast

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