Lipid-rich Carcinoma of the Mammary Gland in a Cat

Kamstock, Debra A.; Fredrickson, R. L.; Ehrhart, E. J.

doi:10.1354/vp.42-3-360

Cited by 19 publications

(17 citation statements)

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“…In the current case peritumoral neoplastic embolization and distant metastases in the right axillary lymph node, right thoracic wall, pleura, lungs, liver, spleen and kidney were seen. In contrast to our study, no metastatic lesions were identified in the feline case reported by Kamstock et al (2005).…”

Section: Resultscontrasting

confidence: 99%

“…Nuclei demonstrated marked atypia, were round to angular, variably sized, predominantly euchromatic, and basophilic with occasional prominent nucleoli. Mitotic figures were infrequent (Kamstock et al, 2005). Neoplastic cells demonstrated intense and diffuse immunoreactivity for cytokeratin and lacked immunoreactivity for vimentin.…”

Section: Resultsmentioning

confidence: 99%

“…However, this tumor type was diagnosed only once in a female cat by Kamstock et al (2005). The author described a 1.5-year-old female, intact, calico, outdoor, farm cat that had a single mass on the ventral abdomen.…”

Section: Resultsmentioning

confidence: 99%

“…Neoplastic cells demonstrated intense and diffuse immunoreactivity for cytokeratin and lacked immunoreactivity for vimentin. The vacuolar contents stained positively with Oil Red-O and negatively with periodic acid-Schiff and Alcian blue stains (Kamstock et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

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A Metastatic Lipid-Rich Carcinoma of the Mammary Gland in a Female Cat: Clinicopathological, Histopathological and Immunohistochemical Features

Gal¹,

Cătoi²,

Taulescu³

et al. 2017

BUASVMCN-VM

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Lipid-rich invasive human breast cancer is a rare enigmatic entity among special types of infiltrating duct carcinoma. Our paper reports a lipid-rich mammary carcinoma in a female cat with the gross, microscopic and immunohistochemical description of the tumor. A 13-year-old intact adult female, mixed-breed cat was presented by the owner to the Laboratory of Pathologic Anatomy from the Faculty of Veterinary Medicine ClujNapoca, Romania. A complete necropsy examination was performed in our laboratory. The tissue samples were collected and processed by paraffin technique for further histological, histochemical, immunofluorescence and immunohistochemical examination. During the necropsy examination, a subcutaneous mass was discovered on the chest. Several variably sized, well-demarcated neoplasms were noted in the right axillary lymph node, right thoracic wall, pleura, lungs, liver, spleen and kidney. Histologically, the cells frequently formed tubuloacinar structures. The morphology of the described tumor showed features of a poorly differentiated mammary carcinoma. Numerous tumoral cells were large and polygonal, with abundant cytoplasm that showed foam-like cytoplasm. The tumoral cells contained either multiple small or large and solitary vacuoles that pushed the nucleus to the periphery of the cell. Intracytoplasmic vacuoles of the neoplastic cells were positive for Oil-Red-O and negatively with Periodic Acid-Schiff. As for immunofluorescence/immunohistochemistry, nonvacuolated and vacuolated neoplastic cells were positive for cytokeratin and negative for vimentin. Histochemical and immunohistochemical analysis support a diagnosis of lipid-rich mammary carcinoma. This is the second reliable record of a lipid-rich mammary carcinoma in female cat and the first one with internal metastases.

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Section: Resultscontrasting

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A Metastatic Lipid-Rich Carcinoma of the Mammary Gland in a Female Cat: Clinicopathological, Histopathological and Immunohistochemical Features

Gal¹,

Cătoi²,

Taulescu³

et al. 2017

BUASVMCN-VM

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“…17 Although the vacuolated cells of the present neoplasm were sometimes arranged in a tubular or cystic growth pattern, lipid-rich carcinomas in the dog and cat are also composed of tubular or tubuloacinar structures formed by lipid-rich neoplastic cells. 6,13 A recent study showed that apocrine secretion by the neoplastic luminal epithelial cells was observed in all 12 reported cases of mammary neoplasms (adenomas and/or carcinomas) in Djungarian hamsters. 8 The recurrent tumor in the present case had multifocal tubular or cystic structures lined by foamy, neutral, lipid-rich neoplastic cells suggesting apocrine secretion.…”

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confidence: 99%

Lipid-Rich Carcinoma in the Mammary Gland of a Djungarian Hamster (Phodopus Sungorus)

et al. 2010

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Abstract. A lipid-rich carcinoma of the mammary gland was diagnosed in a female Djungarian hamster (Phodopus sungorus), which was kept as an indoor pet. The animal underwent surgery for a primary tumor arising in the mammary gland at the age of 16 months, and also for a recurrent tumor 6 months later. Histologically, the primary neoplasm was composed of 2 different cell populations: nonvacuolated glandular neoplastic cells with moderate atypia, and vacuolated neoplastic cells with marked atypia. Transition from the nonvacuolated glandular cells to the vacuolated cells was frequently seen. The recurrent neoplasm was composed predominantly of vacuolated neoplastic cells that often invaded the surrounding soft tissue. The cytoplasmic vacuoles contained neutral lipids, as confirmed by oil red O and Nile blue staining. The vacuolated neoplastic cells were immunopositive for cytokeratin and negative for vimentin, a-smooth muscle actin, p63, estrogen receptor a, and androgen receptor. Presumably, this high-grade, lipid-rich mammary carcinoma had developed from a low-grade mammary adenocarcinoma.Key words: Djungarian hamster; immunohistochemistry; lipid-rich carcinoma; mammary tumor; Phodopus sungorus.In human medicine, lipid-rich carcinoma is a rare variant of invasive breast carcinoma in which tumor cells contain abundant cytoplasmic neutral lipids. 4,16 The morphological features of this neoplasm were first described in a human patient in 1963.1 However, because of the great rarity of this neoplasm, many aspects of its pathology remain to be elucidated. In the veterinary literature, lipid-rich mammary carcinoma has been recognized as a rare neoplasm in 12 female dogs 5,11-13 and 1 female cat. The Djungarian hamster (Phodopus sungorus), also known as the Dzhungarian hamster, Siberian dwarf hamster, or Russian dwarf hamster, is a popular, indoor small pet in Japan. This species is also used as a laboratory animal, although it is used less often than the Syrian hamster (Mesocricetus auratus). In Djungarian hamsters, mammary tumor is one of the most common spontaneous neoplasms, 3,7,8,14,18 and androgen-dependent atypical fibromas are likewise known to arise in the skin with aging. 2 A female Djungarian hamster, which weighed 52 g at the age of 16 months and was kept as an indoor pet, developed a subcutaneous mass at the site of the fourth mammary gland on the left side. At 9 months of age, this hamster had undergone surgery to excise a neoplasm in the first left mammary gland. This neoplasm had been diagnosed as an adenocarcinoma. The present mass in the fourth left mammary gland (the primary tumor) was surgically excised. It measured 2.0 cm 3 1.5 cm 3 1.5 cm and weighed 1.7 g. When the animal was 22 months old and weighed 53 g, the neoplasm in the fourth left mammary gland recurred and was surgically excised again. This mass measured 2.2 cm 3 2.0 cm 3 1.9 cm and weighed 3.9 g. Further follow-up clinical data on the hamster could not be obtained.On gross examination, both the primary and the recurrent neoplasms were bro...

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