Lipid Rafts, G Proteins and the Etiology of and Treatment for Depression: Progress toward a Depression Biomarker

Donati, Robert J.; Rasenick, Mark M.

doi:10.2217/14796708.3.5.511

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…For this purpose, metabolomics is currently a viable and widely used method for finding biomarkers for neuropsychological diseases [25]. Additionally, lipidomics are recommended and have been used in several previous studies to explore the potential biomarkers of depression disorders [26, 27]. However, at present, studies using lipidomics to explore biomarkers of AD are lacking.…”

Section: Introductionmentioning

confidence: 99%

Biomarker screening for antenatal depression in women who underwent caesarean section: a matched observational study with plasma Lipidomics

Zhao

Long

et al. 2019

BMC Psychiatry

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Background Antenatal depression is a prevalent mental disorder in women who have undergone caesarean section, and it often presages adverse postoperative outcomes. Because of the lack of a laboratory-based diagnostic strategy, antenatal depression is mainly determined by a psychologist’s subjective judgment based on a structured clinical interview for established diagnostic criteria. However, the diagnostic accuracy rate for depression by non-psychiatrists is relatively low. Thus, this study aimed to use lipidomics to identify potential biomarkers related to antenatal depression in women who have undergone caesarean section. Methods The study was designed as a matched prospective observational study. Singleton pregnant women scheduled to receive elective caesarean section, were screened for eligibility. Women diagnosed with major antenatal depression were matched with non-antenatal depression controls in terms of age (±1 year) and BMI (±1 kg/m 2 ), and blood samples of the included matched pairs were collected. Subsequently, lipidomics of the plasma samples were performed using Ultra Performance Liquid Chromatography-mass spectrometry analysis to explore the differentially expressed lipids in women with or without antenatal depression. Results In total, 484 pregnant women were screened; 66 subjects were recruited, including 33 subjects with major antenatal depression and 33 matched controls without antenatal depression. Thirty-five differentially expressed lipid metabolites were identified ( P < 0.05). The area under the receiver operating characteristic curve of these lipid metabolites was 0.7 or larger; the area under curve for cholesterol sulfate was 0.823 (95% CI: 0.716–0.930), and that of PC (18:2 (2E, 4E)/0:0) was 0.778 (95%CI: 0.662–0.895). In the conditional logistic stepwise regression analysis, cholesterol sulfate ( P = 0.009) and PC (18:2 (2E, 4E)/0:0) ( P = 0.035) were also identified as effective predictive risk factors for antenatal depression. Conclusions Women who had undergone caesarean section and experienced antenatal depression presented a significantly differentially expressed profile of plasma lipidomics compared to those who did not experience antenatal depression. Cholesterol sulfate and PC (18:2 (2E, 4E)/0:0) may be effective and specific lipidic biomarkers for the prediction of antenatal depression. Trial registration China Clinical Trial Registration Center registration number: ChiCTR1800016230 ; date of registration: 21/05/2018.

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Section: Introductionmentioning

confidence: 99%

Biomarker screening for antenatal depression in women who underwent caesarean section: a matched observational study with plasma Lipidomics

Zhao

Long

et al. 2019

BMC Psychiatry

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“…It has been observed that glucocorticoids exert their effects via their receptors in lipid rafts [223]. In addition, all the conditions mentioned have already been associated with changes in lipid rafts [224][225][226][227].…”

Section: Hormonesmentioning

confidence: 99%

Lipid Rafts: The Maestros of Normal Brain Development

Viljetić,

Blažetić,

Labak

et al. 2024

Biomolecules

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Lipid rafts, specialised microdomains within cell membranes, play a central role in orchestrating various aspects of neurodevelopment, ranging from neural differentiation to the formation of functional neuronal networks. This review focuses on the multifaceted involvement of lipid rafts in key neurodevelopmental processes, including neural differentiation, synaptogenesis and myelination. Through the spatial organisation of signalling components, lipid rafts facilitate precise signalling events that determine neural fate during embryonic development and in adulthood. The evolutionary conservation of lipid rafts underscores their fundamental importance for the structural and functional complexity of the nervous system in all species. Furthermore, there is increasing evidence that environmental factors can modulate the composition and function of lipid rafts and influence neurodevelopmental processes. Understanding the intricate interplay between lipid rafts and neurodevelopment not only sheds light on the fundamental mechanisms governing brain development but also has implications for therapeutic strategies aimed at cultivating neuronal networks and addressing neurodevelopmental disorders.

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“…Many early depression metabolomic studies focused on broad metabolite classes, such as lipids (lipidomics). This was in part due to technologic limitations (Piomelli et al, 2007), although there was a known connection between lipids and neuronal signaling and disease (Allen et al, 2006; Donati and Rasenick, 2008). A meta-analysis of 14 studies comparing the total n-3 polyunsaturated fatty acids (n-3 PUFAs) levels in serum, plasma or erythrocytes in depressed vs non-depressed individuals demonstrated a significantly lower amount of n-3 PUFA in depressed populations (Lin et al, 2010).…”

Section: Biomarker Discovery—tools and Applicationmentioning

confidence: 99%

Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks

Gadad

Jha

Czysz

et al. 2018

Journal of Affective Disorders

127

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Lipid Rafts, G Proteins and the Etiology of and Treatment for Depression: Progress toward a Depression Biomarker

Cited by 4 publications

References 36 publications

Biomarker screening for antenatal depression in women who underwent caesarean section: a matched observational study with plasma Lipidomics

Biomarker screening for antenatal depression in women who underwent caesarean section: a matched observational study with plasma Lipidomics

Lipid Rafts: The Maestros of Normal Brain Development

Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks

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